Results 171 to 180 of about 421,176 (292)

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

Cytokine Profiles and Inflammatory Implications in Chagas Disease: Associations with Ventricular Function and Conduction Disorders. [PDF]

Med Sci (Basel)
Principato M, Carvelli MV, Paolucci AG, Miranda S, Keller GA, Lago M, Di Girolamo G, Carbajales J.   +7 more
europepmc   +1 more source

Reliability of left ventricular volumes and function measurements using three-dimensional speckle tracking echocardiography [PDF]

, 2011
Sebastiaan A. Kleijn, M. F. A. Aly, Caroline B. Terwee, Albert C. van Rossum, Otto Kamp   +4 more
openalex   +1 more source

Targeting DNA‐LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity

Advanced Science, EarlyView.
Attaching antibodies against endothelial cell surface proteins redirects the delivery and expression of DNA‐lipid nanoparticles to organs of interest. Our targeted nanoparticles enable organ‐selective DNA expression in the endothelium of the lungs, brain, or spleen, providing a therapeutic platform for dozens of endothelial‐centric diseases.
Nicolas Marzolini, Taylor V. Brysgel, Ryan J. Rahman, Eno‐Obong Essien, Saw Y. Nwe, Jichuan Wu, Aparajeeta Majumder, Manthan N. Patel, Sachchidanand Tiwari, Carolann L. Espy, Fengyi Dong, Sabrina A. Santos‐De León, Anit Shah, Vladimir V. Shuvaev, Elizabeth D. Hood, Liam S. Chase, Drew Weissman, Jeremy B. Katzen, David B. Frank, Mariko L. Bennett, Oscar A. Marcos‐Contreras, Jacob W. Myerson, Vladimir R. Muzykantov, Sahily Reyes‐Esteves, Jacob S. Brenner   +24 more
wiley   +1 more source

Beta-3 Adrenoreceptor Agonist Mirabegron Improves Right Ventricular Function in a Rat Monocrotaline-Induced Pulmonary Hypertension Model. [PDF]

Pulm Circ
Mendes-Ferreira P, Tielemans B, Wagenaar A, Bouzin C, Adão R, Pokreisz P, De Mulder D, Leite-Moreira A, Brás-Silva C, Balligand JL, Dessy C, Delcroix M, Quarck R, Belge C.   +13 more
europepmc   +1 more source

Increased left ventricular extracellular volume and enhanced twist function in type 1 diabetic individuals [PDF]

, 2017
Zainisha Vasanji, Ronald J. Sigal, Neil D. Eves, Debra Isaac, Matthias G. Friedrich, Kelvin Chow, Richard B. Thompson   +6 more
openalex   +1 more source

Mendelian Randomization and Double Machine Learning Modeling Reveal Brain Imaging‐Derived Phenotypes as Functional Contributors to 18 Autoimmune Inflammatory Diseases

Advanced Science, EarlyView.
This schematic integrates the eight statistically significant causal relationships identified between 1,366 brain imaging‐derived phenotypes (IDPs) and 18 autoimmune inflammatory diseases (AIDs). Arrows indicate the direction of causality inferred from bidirectional two‐sample MR analyses.
Jinbin Chen, Xin Wang, Haifeng Ding, Bosheng Zheng, Keni Zeng, Chuying Hu, Jiayi Liu, Xiao Zhu, Haibing Yu   +8 more
wiley   +1 more source

Left Ventricular Function [PDF]

Anesthesiology, 2016
openaire   +2 more sources

Mid-Term Recovery of Right Ventricular Function and Improvement of Left Ventricular Function After Da Silva Cone Procedure for Ebstein Anomaly. [PDF]

J Cardiovasc Dev Dis
Sundaram K, Stoll V, Da Fonseca Da Silva L, Christopher A, Hoskoppal A, Kreutzer J, Liddle D, Olivieri L, Weinberg J, Dobson CP, Da Silva JP, Alsaied T.   +11 more
europepmc   +1 more source

Effect of hemodialysis on left and right ventricular function - Evaluation using electrocardiogram gated radionuclide ventriculography.

, 1986
T Muto, Takeshi Morishita, Shun Iida, Junichi Yamazaki, Ryuko Aoki, Yasuaki Kawamura, I Okuzumi, Takehiro Ohara, Mitsuji Moriki, K Hirata, Yasuhito Sasaki   +10 more
openalex   +2 more sources