Results 41 to 50 of about 15,739 (215)

Age-Dependent Decline in Cardiac Function in Guanidinoacetate-N-Methyltransferase Knockout Mice

Frontiers in Physiology, 2020
AimGuanidinoacetate N-methyltransferase (GAMT) is the second essential enzyme in creatine (Cr) biosynthesis. Short-term Cr deficiency is metabolically well tolerated as GAMT–/– mice exhibit normal exercise capacity and response to ischemic heart failure.
Dunja Aksentijević, Sevasti Zervou, Thomas R. Eykyn, Debra J. McAndrew, Julie Wallis, Jurgen E. Schneider, Stefan Neubauer, Craig A. Lygate   +7 more
doaj   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Tako-tsubo cardiomyopathy observed in a patient with sepsis and transient hyperthyroidism

Monaldi Archives for Chest Disease, 2016
ischemic stroke with residual left hemiparesis, was admitted to our hospital because of dyspnoea with clinical evidence of acute pulmonary edema.
Filippo M. Sarullo, Luigi Americo, Salvatore Accardo, Sergio Cicero, Rossella Schicchi, Maria Schirò, Antonio Castello   +6 more
doaj   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Efeitos da angiotensina-I e isquemia na recuperação funcional em corações isolados Effects of angiotensin-I and ischemia on functional recovery in isolated hearts

Arquivos Brasileiros de Cardiologia, 2011
FUNDAMENTO: A ressuscitação de parada cardíaca pode apresentar disfunção miocárdica determinada pelo tempo da isquemia, e a inibição da enzima conversora de angiotensina (ECA) pode reduzir a disfunção cardíaca durante a reperfusão.
Ubirajara Oliveira de Oliveira, Álvaro Reischak de Oliveira, Luiz Carlos Kucharski, Ubiratan Fabres Machado, Maria Claudia Irigoyen, Beatriz D'Agord Schaan   +5 more
doaj  

Influence of the elevation of the left ventricular diastolic pressure on the values of the first temporal derivative of the ventricular pressure (dP/dt)

Arquivos Brasileiros de Cardiologia, 1999
PURPOSE: To assess the effects of the elevation of the left ventricular end-diastolic pressure (LVEDP) on the value of the 1st temporal derivative of the ventricular pressure (dP/dt). METHODS: Nineteen anesthetized dogs were studied.
Katashi Okoshi, José Roberto Fioretto, Rossano César Bonatto, Maria Teresinha Trovarelli Tornero, Paulo José Tucci   +4 more
doaj   +1 more source

The results of the treatment of right ventricle myocardial infarction [PDF]

Vojnosanitetski Pregled, 2005
Aim. To present the results and experience in diagnosing and treating of patients with acute right ventricle infarction, during the period of hospitalization of one month, with adjuvant analyses of the obtained results in the period of fifteen years ...
Rafajlovski Saša I., Orozović Vjekoslav, Rađen Goran, Ristić-Anđelkov Anđelka   +3 more
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Papel do ecocardiograma na avaliação ventricular do coração transplantado versus rejeição cardíaca Role of echocardiography in the ventricular assessment of the transplanted heart versus heart rejection

Arquivos Brasileiros de Cardiologia, 2012
FUNDAMENTO: O Transplante Cardíaco (TC) é uma alternativa para os indivíduos com doença cardíaca terminal. Na evolução pós-transplante, a ocorrência de episódios de Rejeição Cardíaca (RC) é evento frequente que aumenta a morbimortalidade, sendo ...
Gabriel Antonio Stanisci Miguel, Salomón Soriano Ordinola Rojas, Reinaldo Wilson Vieira, José Pedro da Silva, Henry Abensur   +4 more
doaj  

Artificial Intelligence-Based Left Ventricular Ejection Fraction by Medical Students for Mortality and Readmission Prediction

Diagnostics
Introduction: Point-of-care ultrasound has become a universal practice, employed by physicians across various disciplines, contributing to diagnostic processes and decision-making. Aim: To assess the association of reduced (
Ziv Dadon, Moshe Rav Acha, Amir Orlev, Shemy Carasso, Michael Glikson, Shmuel Gottlieb, Evan Avraham Alpert   +6 more
doaj   +1 more source