Results 41 to 50 of about 664,353 (304)

A exposição crônica à fumaça do cigarro resulta em remodelação cardíaca e prejuízo da função ventricular em ratos Chronic cigarette smoke exposure results in cardiac remodeling and impaired ventricular function in rats

Arquivos Brasileiros de Cardiologia, 2005
OBJETIVO: Determinar as alterações cardíacas estruturais e funcionais causadas pela exposição à fumaça do cigarro em ratos. MÉTODOS: Os animais foram aleatoriamente distribuídos em dois grupos: fumante (F), composto por 10 animais, expostos à fumaça do ...
Édson Castardeli, Sergio A. R. Paiva, Beatriz B. Matsubara, Luiz S. Matsubara, Marcos F. Minicucci, Paula S. Azevedo, Álvaro O. Campana, Leonardo A. M. Zornoff   +7 more
doaj   +1 more source

Three-dimensional echocardiography and 2D-3D speckle tracking imaging in chronic pulmonary hypertension. diagnostic accuracy in detecting hemodynamic signs of RV failure [PDF]

, 2015
Background and objective. Our aim was to compare three-dimensional (3D) and 2D and 3D speckle tracking (2D-STE, 3D-STE) echocardiographic parameters with conventional right ventricular (RV) indexes in patients with chronic pulmonary hypertension (PH ...
Alessia, Azzano, Capotosto, Lidia, Gaudio, Carlo, Mangieri, Enrico, Nino, Cocco, Rasul, Ashurov, Rosato, Edoardo, Salsano, Felice, Simona, D’Orazio, Terzano, Claudio, Truscelli, Giovanni, Vitarelli, Antonino   +11 more
core   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Mechanisms mediating muscle metaboreflex control of cardiac output during exercise: Impaired regulation in heart failure

Experimental Physiology
The ability to increase cardiac output during dynamic exercise is paramount for the ability to maintain workload performance. Reflex control of the cardiovascular system during exercise is complex and multifaceted involving multiple feedforward and ...
Donal S. O'Leary, Joseph Mannozzi
doaj   +1 more source

The Role of Invasive Procedures in the Treatment of Complicated Gastrointestinal Graft‐Versus‐Host Disease in Pediatric Patients

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Gastrointestinal graft‐versus‐host disease (GI GVHD) following hematopoietic stem cell transplant is typically managed with medical therapy, but surgery and angioembolization may be warranted in selected cases with life‐threatening complications.
Gaia Brunetti, Giorgio Persano, Chiara Grimaldi, Pier Luigi Di Paolo, Carmen Malaspina, Francesco Quagliarella, Valerio Balassone, Anna Chiara Iolanda Contini, Gian Luigi Natali, Rita Alaggio, Ivan Pietro Aloi, Tamara Caldaro, Alessandro Crocoli   +12 more
wiley   +1 more source

Assessment of Myocardial Fibrosis in Marfan Syndrome Using Cardiac Magnetic Resonance Imaging

Molecular Genetics & Genomic Medicine
Background Impaired myocardial function and arrhythmia are important manifestations of Marfan syndrome (MFS). Studies assessing myocardial fibrosis in relation to these manifestations are scarce. Methods This cross‐sectional, single‐center study assessed
Anthony Demolder, Dan Devos, Julie De Backer, Laura Muiño‐Mosquera   +3 more
doaj   +1 more source

Quasi-static imaged-based immersed boundary-finite element model of human left ventricle in diastole [PDF]

, 2014
SUMMARY: Finite stress and strain analyses of the heart provide insight into the biomechanics of myocardial function and dysfunction. Herein, we describe progress toward dynamic patient-specific models of the left ventricle using an immersed boundary ...
Balay, Belytschko, Boffi, Colella, Costa, de Vecchi, Dokos, Fai, Gresho, Griffith, Griffith, Griffith, Griffith, Griffith, Griffith, Guccione, Göktepe, Heltai, Holzapfel, Hornung, Kim, Kim, Kirk, Klotz, Kovács, Krishnamurthy, Lai, LeGrice, Liu, Luo, Ma, May-Newman, McCormick, McQueen, McQueen, McQueen, Mori, Nash, Niederer, Nordsletten, Ogden, Omens, Peskin, Peskin, Potse, Rider, Shmuylovich, Smith, Stevens, Szabó, Usyk, Vetter, Wang, Wang, Watanabe, Wenk, Zhang, Zhang, Zhu, Zile   +59 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Cardiac magnetic resonance findings predict increased resource utilization in elective coronary artery bypass grafting [PDF]

, 2008
Morbidity following CABG (coronary artery bypass grafting) is difficult to predict and leads to increased healthcare costs. We hypothesized that pre-operative CMR (cardiac magnetic resonance) findings would predict resource utilization in elective CABG ...
Alfakih, American Heart Association, Anna F. Dominiczak, Baks, Bellenger, Berry, Berry, British Heart Foundation Heart Statistics, Christian Delles, Colin Berry, Eisenberg, Ferguson, Fieno, Geissler, Geoffrey A. Berg, Gibbons, Hein, Henry J. Dargie, Higgins, Higgins, Hombach, John E. Foster, Lassnigg, Lorenz, Lukas U. Zimmerli, Lund, Mark, Michalopoulos, Mosteller, Mounsey, Nathanson, Pell, Pennell, Roques, Rosamond, Schvartzman, Selvanayagam, Sievers, Simonetti, Tracey Steedman, Tu, Tu, Zimmerli   +42 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source