Results 81 to 90 of about 70,103 (352)

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Prevention of LVOT Obstruction by Device-Mediated Laceration of the Anterior Mitral Valve Leaflet During TMVR

JACC: Case Reports, 2023
Left ventricular outflow tract obstruction represents a life-threatening complication in patients undergoing transcatheter mitral valve replacement. Interventional approaches to prevent left ventricular outflow tract obstruction are complex and require ...
Sebastian Ludwig, MD, Daniel Kalbacher, MD, Lara Waldschmidt, MD, Andreas Schaefer, MD, MHBA, MD, Thomas Modine, MD, PhD, Danny Dvir, MD, Shemy Carasso, MD, Paolo Denti, MD, Niklas Schofer, MD, Lenard Conradi, MD   +9 more
doaj  

Effect of iron overload on electrophysiology of slow reaction autorhythmic cells of left ventricular outflow tract in guinea pigs

Asian Pacific Journal of Tropical Medicine, 2018
Objective: To investigate the electrophysiology effects and mechanism of iron overload on the slow response autorhythmic cells in the left ventricular outflow tract of guinea pigs.
Ling Fan, Li-Feng Chen, Jing Fan, Lan-Ping Zhao, Xiao-Yun Zhang   +4 more
doaj   +1 more source

Considerations for drug trials in hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1095-1112, April 2025.
Abstract Hypertrophic cardiomyopathy (HCM) is a heterogeneous condition with potentially serious manifestations. Management has traditionally comprised therapies to palliate symptoms and implantable cardioverter‐defibrillators to prevent sudden cardiac death. The need for disease‐modifying therapies has been recognized for decades.
John P. Farrant, Matthias Schmitt, Anna B. Reid, Clifford J. Garratt, William G. Newman, Aneil Malhotra, Rhys Beynon, Masliza Mahmod, Betty Raman, Robert M. Cooper, Dana Dawson, Thomas Green, Sanjay K. Prasad, Anvesha Singh, Susanna Dodd, Hugh Watkins, Stefan Neubauer, Christopher A. Miller   +17 more
wiley   +1 more source

The living aortic valve: From molecules to function. [PDF]

, 2014
The aortic valve lies in a unique hemodynamic environment, one characterized by a range of stresses (shear stress, bending forces, loading forces and strain) that vary in intensity and direction throughout the cardiac cycle.
Bertazzo, S, Butcher, JT, Chester, AH, El-Hamamsy, I, Latif, N, Yacoub, MH   +5 more
core   +1 more source

Catheter ablation of right ventricular outflow tract tachycardia using contact force guidance [PDF]

, 2014
Outflow tract tachycardias (OTT) originating from the right or left ventricular outflow tract are thought to be benign. However, symptoms can be disabling and deterioration of left ventricular function may occur with a high arrhythmia burden.
Groot, N.M.S. (Natasja) de, Jordaens, L.J.L.M. (Luc), Valk, S.D.A. (Suzanne)   +2 more
core   +3 more sources

Left atrial to coronary sinus shunting in more advanced heart failure with preserved ejection fraction

ESC Heart Failure, Volume 12, Issue 4, Page 2583-2590, August 2025.
Abstract Aims Inter‐atrial shunt device therapy has shown mixed results in clinical trials, with clinical ‘non‐responders’ typically showing features of more advanced heart failure. We aimed to analyse the haemodynamic and clinical response of a novel left atrial to coronary sinus (LA‐CS) shunt device in patients with higher natriuretic peptide (NP ...
Ryan J. Tedford, Brian A. Houston, JoAnn Lindenfeld, Rami Kahwash, Marcus A. Urey, Nicholas S. Amoroso, Benjamin Hibbert, Firas Zahr, William A. Gray, Javed Butler   +9 more
wiley   +1 more source

Radiofrequency Catheter Ablation of Atrioventricular Nodal Reentrant Tachycardia: It Is Not Always As It Is Expected [PDF]

, 2004
Observation of Coincident arrhythmias is not uncommon but the co-existence of idiopathic verapamil sensitive left ventricular tachycardia (ILVT) with other arrhythmias is very rare.
Arya, Arash, Emkanjoo, Zahra, Haghjoo, Majid, Heydari, Alireza, Sadr-Ameli, Mohammad Ali   +4 more
core   +1 more source

The early stages of heart development: insights from chicken embryos [PDF]

, 2016
The heart is the first functioning organ in the developing embryo and the detailed understanding of the molecular and cellular mechanisms involved in its formation provides insights into congenital malformations affecting its function and therefore the ...
Alsan, Arguello, de la Cruz, de La Cruz, de la Cruz, DeHaan, Hatada, Kitajima, Le Lievre, Needham, Plein, Psychoyos, Rosenquist, Schultheiss, Stern, Tam, Vincent, Waldo, Yatskievych, Zhang   +19 more
core   +2 more sources

GEO combined with quantitative protein trait loci identify causative proteins in hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 4, Page 2827-2833, August 2025.
Abstract Aims Hypertrophic cardiomyopathy (HCM) is a rare genetic heart disease characterized by a limited patient population and scarce research and treatment resources. This study aimed to identify HCM‐associated proteins by integrating cardiac tissue data from the Gene Expression Omnibus (GEO) database with the latest protein quantitative trait ...
Bo Li, Xu Zhao, Yan Ding, Yi Zhang
wiley   +1 more source