Results 271 to 280 of about 61,734 (360)

Clinical Evaluation of the Effect of Aficamten on QT/QTc Interval in Healthy Participants

Clinical and Translational Science, Volume 18, Issue 4, April 2025.
ABSTRACT Aficamten is a next‐in‐class, small‐molecule, cardiac myosin inhibitor in development for treating hypertrophic cardiomyopathy (HCM). This 2‐part study evaluated aficamten's impact on QTc interval in healthy participants. Part A (n = 10) was an open‐label study to find the appropriate dose for thorough QT (TQT) evaluation in Part B. Part B (n =
Neha Maharao, Donghong Xu, Tyrell J. Simkins, Owen Bowles, Genzhou Liu, Youcef Benattia, Adrienne Griffith, Stephen B. Heitner, Stuart Kupfer, Polina German   +9 more
wiley   +1 more source

Catheter Ablation of Parahisian Premature Ventricular Complexes From the Right Sinus of Valsalva

Journal of Cardiovascular Electrophysiology, Volume 36, Issue 4, Page 731-738, April 2025.
ABSTRACT Background Cather ablation of parahisian premature ventricular complexes (PVCs) often requires ablation in multiple cardiac chambers, including the sinuses of Valsalva (SoV). The safety and efficacy of ablation within the right SoV to target parahisian arrhythmias has not been widely reported.
Michael Ghannam, Jamie Simpson, Mohamed Al‐Sadawi, Amrish Deshmukh, Jackson J. Liang, Rakesh Latchamsetty, Thomas Crawford, Krit Jongnarangsin, Hakan Oral, Frank Bogun   +9 more
wiley   +1 more source

Right ventricular outflow tract obstruction by cardiac hemangioma in asymptomatic patient. [PDF]

J Surg Case Rep
Kaewboonlert N, Chunharas P, Pluthikarmpae N, Poontananggul J, Wongthep A, Pongsuwan N, Lerssuttipon U.   +6 more
europepmc   +1 more source

Right Ventricular Myxoma with Partial Right Ventricular Outflow Tract Obstruction

, 2006
Frank J. van der Heusen, Greg Stratmann, Isobel A. Russell   +2 more
openalex   +1 more source

Cyclin‐dependent kinase 13 is indispensable for normal mouse heart development

Journal of Anatomy, Volume 246, Issue 4, Page 616-630, April 2025.
Congenital heart disease (CHD) is the most common defect in live births. The role of cyclin‐dependent kinase (CDK13) in cardiogenesis and CHD was studied using a transgenic mouse model (Cdk13tm1b) carrying deletion of exons 3 and 4, causing loss of function.
Qazi Waheed‐Ullah, Anna Wilsdon, Aseel Abbad, Sophie Rochette, Frances Bu'Lock, Asma Ali Saed, Marc‐Phillip Hitz, J. David Brook, Siobhan Loughna   +8 more
wiley   +1 more source

An atypical case of right ventricular myxoma, a paradox of pulmonary valve endocarditis with right ventricular outflow tract obstruction. From a surgeon's perspective. [PDF]

J Surg Case Rep
Samsuddin MJ, Yaacob SS, Sanusi ARB.
europepmc   +1 more source

The physiology, anatomy and stimulation of the vagus nerve in epilepsy

The Journal of Physiology, Volume 603, Issue 8, Page 2201-2217, 15 April 2025.
Abstract figure legend The vagus nerve is both the longest cranial nerve and the largest, providing parasympathetic control of multiple organ systems within the thorax and abdomen, including the cardiovascular, respiratory and gastrointestinal systems (Ottaviani & Macefield, 2022).
Mikaela Patros, Shobi Sivathamboo, Hugh D. Simpson, Terence J. O'Brien, Vaughan G. Macefield   +4 more
wiley   +1 more source

Dynamic right ventricular outflow tract obstruction due to straight back syndrome and funnel chest - A pediatric case. [PDF]

J Cardiol Cases
Sugiyama K, Ishido H, Iwamoto Y, Tanikawa S, Korematsu S, Masutani S.   +5 more
europepmc   +1 more source

Mechanistic evaluation of ertugliflozin in patients with type 2 diabetes and heart failure

Physiological Reports, Volume 13, Issue 7, April 2025.
HF patients exhibit counterregulatory adaptations to tubular sodium handling. SGLT2 inhibition shifts systemic volume toward a state of euvolemia, potentially lowering the risk of worsening HF. Abstract The effect of sodium‐glucose cotransporter‐2 (SGLT2) inhibitor ertugliflozin on fluid volume and kidney function was assessed in patients with type 2 ...
Yuliya Lytvyn, Rosalie A. Scholtes, Eva M. Boorsma, Vikas S. Sridhar, Luxcia Kugathasan, Hongyan Liu, Leif E. Lovblom, Louis Handoko, Charlotte M. Mosterd, John S. Floras, Kevin Burns, Tosin Osuntokun, Adriaan Voors, Daniel H. van Raalte, Hiddo J. L. Heerspink, David Z. I. Cherney   +15 more
wiley   +1 more source

A case report of severe left ventricular outflow tract obstruction in a middle-aged adult with chest pain and shock. [PDF]

Heliyon
Chen C, Yang X, Hu Y.
europepmc   +1 more source