Results 111 to 120 of about 2,023 (217)

Immune checkpoint inhibitor‐induced arrhythmias: Mechanistic insights from clinical and preclinical studies

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, but their efficacy continues to be limited by immune‐related adverse events. Among these, ICI‐induced cardiac arrhythmias are increasingly recognised as a major adverse reaction, encompassing a broad spectrum of clinical phenotypes, including conduction blocks, atrial fibrillation and
Anand R. Ramalingam, Zoltán Márton Köhler, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

Inhibition of late sodium current prevents pathological hyperactivation of calcium/calmodulin‐dependent protein kinase IIδ in a murine model of acute doxorubicin‐related cardiotoxicity

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Doxorubicin (DOX) is a highly effective anthracycline, whose clinical application for cancer is limited by cardiotoxicity. The mechanisms underlying doxorubicin‐induced toxic cardiomyopathy (DICM) involve electrophysiological remodelling with intracellular Na+ overload because of increased late INa and hyperactivation of
Anna‐Lena Feder, Anna‐Maria Pfützenreuter, Lea Maria Funke, Maria Johanna Baier, Daniel Tarnowski, Laura Stengel, Lars Siegfried Maier, Can Martin Sag   +7 more
wiley   +1 more source

Arrhythmias associated with immune checkpoint inhibitor therapy—A clinical perspective

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but are associated with a growing spectrum of cardiovascular immune‐related adverse events. Among these, arrhythmias represent a rare yet potentially life‐threatening complication. ICI‐induced arrhythmias encompass a wide clinical spectrum, including atrial arrhythmias, conduction ...
Dong Wang, Melanie Ricke‐Hoch, David Duncker, Johann Bauersachs, Dominik Berliner   +4 more
wiley   +1 more source

Light Chain Monoclonal Gammopathy of Undetermined Significance: Diagnosis, Biology, and Clinical Management

European Journal of Haematology, EarlyView.
ABSTRACT Light chain monoclonal gammopathy of undetermined significance (LC‐MGUS) is defined by an abnormal serum free light chain ratio and elevated involved light chain in the absence of a detectable immunoglobulin heavy chain on immunofixation and of end‐organ damage attributable to a plasma cell disorder.
Sigurður Yngvi Kristinsson, Thórir Einarsson Long, Sigrún Thorsteinsdóttir   +2 more
wiley   +1 more source

Tachycardia in the Presence of Ventricular Pacing

Texas Heart Institute Journal, 2019
Toug, Tanavin, Mark, Pollet, Yochai, Birnbaum   +2 more
openaire   +2 more sources

Catheter Ablation: Evolution and Efficiencies

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT The present review includes a discussion the goals and pitfalls of efficiency in the medical profession, a historical perspective on the evolution of catheter ablation in the field of electrophysiology (EP), and the data regarding the relationship between efficiency and outcomes in the EP lab. Focus on efficacy is critical to maximize resource
Aravind G. Kalluri, Bradley P. Knight
wiley   +1 more source

Clinical Utility of Tissue Proximity Indication With a Variable‐Loop Circular Catheter for Pulmonary Vein Isolation

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Background The variable‐loop circular catheter (VLCC, VARIPULSE) is a pulsed‐field ablation (PFA) catheter equipped with a Tissue Proximity Indication (TPI) function, which monitors catheter‐tissue contact. Although TPI‐negative sites have been reported to contribute to gap formation, no studies have evaluated the utility of real‐time function.
Masataka Narita, Daisuke Kawano, Naomichi Tanaka, Tsukasa Naganuma, Wataru Sasaki, Kazuhisa Matsumoto, Kei Matsumoto, Hitoshi Mori, Yoshifumi Ikeda, Ritsushi Kato   +9 more
wiley   +1 more source

Comparison of Pentaspline Pulsed Field Ablation Catheter Mapping Modes to Assess Pulmonary Vein Isolation for Paroxysmal Atrial Fibrillation

Journal of Cardiovascular Electrophysiology, EarlyView.
Pentaspline mapping in pulsed field AF ablation. ABSTRACT Background We assessed the electro‐anatomic mapping (EAM) capabilities of a pulsed field ablation (PFA) system previously guided by fluoroscopy to assess acquisition modes, and effects of near and far‐field signal.
John L. Fitzgerald, Geoffroy Ditac, Konstantinos Vlachos, Nicolas Johner, Xavier Paul Bouteiller, Kinan Kneizeh, Francesco Notaristefano, Karim Benali, Cinzia Monaco, Marianne T. Langlois, Benjamin Sacristan, Jan Charton, Romain Tixier, Nicolas Derval, Thomas Pambrun, Mélèze Hocini, Michel Haïssaguerre, Josselin Duchateau, Pierre Jaïs, Frédéric Sacher   +19 more
wiley   +1 more source

Impact of Carina Width on Re‐Ablation Rate of Atrial Fibrillation After Primary Cryoballoon‐Ablation

Journal of Cardiovascular Electrophysiology, EarlyView.
Right side carina width is associated with the incidence of reconnection of RPVs and re‐ablation. Increased left side carina width was associated with re‐ablation rate, but there was no association with reconnection of the LPVs. ABSTRACT Background Reconnection of the pulmonary veins (PVs) is the primary cause of atrial fibrillation (AF) episodes after
Miriam Müller, Marja Hedman, Marianne Heikkilä, Juhani Junttila   +3 more
wiley   +1 more source

The V6R/V4R Index: A Novel ECG Parameter for Identifying Idiopathic Ventricular Arrhythmias Originating From the Aortic Cusp

Journal of Cardiovascular Electrophysiology, EarlyView.
The V6R/V4R amplitude index is a novel and practical electrocardiographic parameter for identifying idiopathic ventricular arrhythmias originating from the aortic cusp. A cutoff >0.55 accurately distinguishes cusp from adjacent non‐cusp origins within the left ventricular outflow tract, facilitating targeted mapping and procedural planning.
Yoshihisa Naruse, Kohki Nakamura, Kanae Hasegawa, Toshihiko Tsuji, Machiko Miyoshi, Tatsuhiro Kataoka, Hideyuki Aoki, Yoshinori Okazaki, Shigeto Naito, Hiroshi Tada, and other members of the V6R/V4R Study Group, Tomoki Kaeriyama, Shigeki Horiguchi, Kaori Hisazaki, Takehito Sasaki, Kentaro Minami, Yutaro Kaneko, Taro Narumi, Makoto Sano, Yuichiro Maekawa   +19 more
wiley   +1 more source