Results 61 to 70 of about 49,144 (342)

Novel Electroactive Therapeutic Platforms for Cardiac Arrhythmia Management

Advanced Science, EarlyView.
Electroactive platforms offer promising applications in cardiac arrhythmia. Based on their energy sources and mechanisms, electroactive platforms are categorized into i) direct electrical stimulation, ii) self‐powered electroactive systems, iii) physical stimuli‐mediated electroactive systems, and iv) conductive systems, and their applications in ...
Juwei Yang, Longfei Li, Yiran Hu, Zhou Li, Wei Hua   +4 more
wiley   +1 more source

Repurposing With Purpose: Treatment of Bachmann–Bupp Syndrome With Eflornithine and Implications for Other Polyaminopathies

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Rare diseases impact approximately 1 in 10 people worldwide, and yet, less than 5% of all rare diseases currently have an approved treatment option available. This is due to many challenges unique to rare diseases, including small, diverse patient populations, the cost of drug development that is not proportionate to the number of patients who
Caleb P. Bupp, Elizabeth A. VanSickle, Julianne Michael, Chad R. Schultz, Kelly Nguyen, Melissa Hoefer, Surender Rajasekaran, André S. Bachmann   +7 more
wiley   +1 more source

KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential

Medicinal Research Reviews, Volume 43, Issue 1, Page 237-287, January 2023., 2023
Abstract The transcription factor nuclear factor erythroid 2‐related factor 2 (NRF2) is considered the master regulator of the phase II antioxidant response. It controls a plethora of cytoprotective genes related to oxidative stress, inflammation, and protein homeostasis, among other processes.
Enrique Crisman, Pablo Duarte, Esteban Dauden, Antonio Cuadrado, María Isabel Rodríguez‐Franco, Manuela G. López, Rafael León   +6 more
wiley   +1 more source

Alzheimer's Association clinical practice guideline for the Diagnostic Evaluation, Testing, Counseling, and Disclosure of Suspected Alzheimer's Disease and Related Disorders (DETeCD‐ADRD): Executive summary of recommendations for primary care

Alzheimer's &Dementia, EarlyView.
Abstract US clinical practice guidelines for the diagnostic evaluation of cognitive impairment due to Alzheimer's disease (AD) or AD and related dementias (ADRD) are decades old and aimed at specialists. This evidence‐based guideline was developed to empower all—including primary care—clinicians to implement a structured approach for evaluating a ...
Alireza Atri, Bradford C. Dickerson, Carolyn Clevenger, Jason Karlawish, David Knopman, Pei‐Jung Lin, Mary Norman, Chiadi Onyike, Mary Sano, Susan Scanland, Maria Carrillo   +10 more
wiley   +1 more source

Changes of Sympathetic Activity in Patient with Chronic Atrial Fibrillation and Severe Congestive Heart Failure Treated with Biventricular Pacing

Journal of Arrhythmia, 2006
The patient was a 64-year-old man with chronic atrial fibrillation with bradycardia. Left ventricular ejection fraction was 34%. He was treated with biventricular pacing. Heart failure improved from NYHA class III to II.
Kohei Matsushita, MD, Toshiyuki Ishikawa, MD, Shinichi Sumita, MD, Tsukasa Kobayashi, MD, Hideyuki Ogawa, MD, Noriko Inoue, MD, Katsumi Matsumoto, MD, Minoru Taima, MD, Ichirou Nakazawa, MD, Teruyasu Sugano, MD, Tomoaki Ishigami, MD, Kazuaki Uchino, MD, Kazuo Kimura, MD, Satoshi Umemura, MD   +13 more
doaj   +1 more source

In vivo toxic and lethal cardiorespiratory effects of a synthetic quaternary ammonium salt derivative of haloperidol in mice

Animal Models and Experimental Medicine, EarlyView.
Hematoxylin–eosin (H&E) stains of the heart, liver, lung, and kidney show acute toxicity. Abstract Background To investigate the toxicity of N‐n‐butyl haloperidol iodide (F2), a quaternary ammonium salt derivative of haloperidol, in mice for potential therapeutic purposes. Methods The acute median lethal dose (LD50) of F2 was determined using the Bliss
Jilin Liao, Binger Lu, Jinhua Yang, Xiaowan Wang, Shuxian Li, Hongbo Fu, Fenfei Gao   +6 more
wiley   +1 more source

Conduction System Pacing in Children and Congenital Heart Disease

Arrhythmia & Electrophysiology Review
Permanent cardiac pacing in children with congenital complete atrioventricular block (CCAVB) and/or congenital heart disease (CHD) is challenging.
Óscar Cano, Jeremy P Moore
doaj   +1 more source

Functional characteristics of left ventricular synchronization via right ventricular outflow-tract pacing detected by two-dimensional strain echocardiography

Journal of Arrhythmia, 2017
Background: Recently, due to the detrimental effects on the ventricular function associated with right ventricular apical (RVA) pacing, right ventricular septal (RVS) pacing has become the preferred pacing method.
Yasutaka Hirayama, MD, Yuichiro Kawamura, MD, PhD, Nobuyuki Sato, MD, PhD, Tatsuya Saito, MD, PhD, Hideichi Tanaka, MD, PhD, Yasuaki Saijo, MD, PhD, Kenjiro Kikuchi, MD, PhD, Katsumi Ohori, MD, PhD, Naoyuki Hasebe, MD, PhD   +8 more
doaj   +1 more source

Terminating ventricular tachycardia by pacing induced dynamical inhomogeneities in the reentry circuit [PDF]

arXiv, 2004
Formation of feedback loops of excitation waves (reentrant circuit) around non-conducting ventricular scar tissue is a common cause of lethal cardiac arrhythmias, such as ventricular tachycardia. This is typically treated by rapid stimulation from an implantable device (ICD). However, the mechanisms of reentry termination success and, more importantly,
arxiv  

Nuclear parcellation of pontine catecholaminergic and cholinergic neurons in gray parrots and pied crow brains

The Anatomical Record, EarlyView.
Immunohistochemical staining for tyrosine hydroxylase reveals the neurons forming the locus coeruleus complex in the pontine region of the brain of the Congo gray parrot. The appearance and parcellation of the locus coeruleus complex in birds shows many similarities, but also differences to that observed in mammals.
Pedzisai Mazengenya, Paul R. Manger
wiley   +1 more source