Results 121 to 130 of about 15,647 (258)

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, EarlyView.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source

Chd4 and ThPOK cooperate to preserve structural and electrophysiological integrity of the adult heart through Sprr1a repression

The FEBS Journal, EarlyView.
Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi, Apolonia Novillo, Rocío Brea, Marta Ysbert, Lorena Cussó, Gonzalo Pizarro‐Sánchez, Manuel Desco, Iván Hernández, Ángel Luis Armesilla, Ignacio Pérez de Castro, Alicia R. Folgueras, Juan Miguel Redondo, Pablo Gómez‐del Arco   +12 more
wiley   +1 more source

Zero‐Contrast Versus Contrast‐Guided Left Atrial Appendage Occlusion: A Comparative Analysis of Procedural and Long‐Term Outcomes

Journal of Cardiovascular Electrophysiology, EarlyView.
Zero‐contrast left atrial appendage occlusion yielded high procedural success and similar periprocedural adverse event rates compared to the contrast‐guided approach. At 45‐day follow‐up, successful LAA closure (defined as peri‐device leak ≤ 5 mm) and device‐related thrombus rates were similar.
Joe Demian, Andrew LaCombe, Arwa Younis, Mohamed Kanj, Walid I. Saliba, Pasquale Santangeli, Chadi Tabaja, Ioan Liuba, Bryan Baranowski, Tyler L. Taigen, Mandeep Bhargava, Oussama M. Wazni, Ayman A. Hussein   +12 more
wiley   +1 more source

Intracardiac Echocardiography and Coronary Angiography During Ventricular Ablation From the Aortic Cusps and Commissures: Marked Inter‐Center Variability Without an Observed Coronary Injury Signal

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Introduction Catheter ablation of premature ventricular complexes (PVCs) and ventricular tachycardia (VT) arising from the aortic cusps and commissures is effective but performed near the coronary ostia, raising concern for coronary injury. Adjunct imaging with intracardiac echocardiography (ICE) and coronary angiography is variably used, and ...
Dakota De Cecco, Jeanne du Fay de Lavallaz, Henry D. Huang, Boldizsar Kovacs, Jennifer Beney, Tobias Reichlin, Patrick Badertscher, Fabian Jordan, Christian Sticherling, Jackson J. Liang   +9 more
wiley   +1 more source

PVC Variability and Impact on Meeting Expert Consensus Cutoffs of ≥ 10 000 PVCs/Day and ≥ 15% PVCs

Journal of Cardiovascular Electrophysiology, EarlyView.
14‐day Zio® (iRhythm) datasets of 606 patients between December 2018 and January 2019 who had at least one day of ≥10,000 PVCs were acquired. Of these patients, a subcohort of 325 patients who had at least one day of ≥15% PVCs was generated. In both groups, analyses were carried out showing that longer duration monitoring increased sensitivity for ...
Richard S. Amara, Justin Brilliant, Jason Appelbaum, Ameer Abutaleb, Rama Vunnam, Stephen R. Shorofsky, Jeffrey N. Rottman, Ardit Kacorri, Timm M. Dickfeld   +8 more
wiley   +1 more source

Long‐Term Serial Exercise Stress Testing in Catecholaminergic Polymorphic Ventricular Tachycardia on Beta‐Blocker and Flecainide Therapy

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Introduction Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially life‐threatening arrhythmic disorder typically treated with beta‐blockers and, occasionally, with flecainide. Methods All patients underwent genetic testing, electrocardiogram, echocardiogram, and exercise testing.
Fernando Wangüemert‐Perez, German Ostos‐Cañero, Marta Wangüemert‐Guerra, Carlos Acosta‐Materan, Aridane Cárdenes‐león, Eduardo Caballero‐Dorta, Kevin Pérez‐Rodríguez, Ramón Brugada, Josep Brugada, Efrén Martínez‐Quintana   +9 more
wiley   +1 more source

Giants in the cold: Morphological evidence for vascular heat retention in the viscera but not the skeletal muscle of the basking shark (Cetorhinus maximus)

Journal of Fish Biology, EarlyView.
Abstract Fewer than 50 of the over 30,000 extant species of fishes have developed anatomical specializations facilitating endothermy in specific body regions. The plankton‐feeding basking shark (Cetorhinus maximus), traditionally classified as an ectotherm, was recently shown to have regionally endothermic traits such as centralized red muscle (RM ...
C. Antonia Klöcker, Axel Schlindwein, Martin C. Arostegui, Ingrid M. Bruvold, Joel V. Wernström, Montserrat Martin‐Armas, David W. Sims, Nicolas Straube, Andreas Altenburger, Claudia Junge   +9 more
wiley   +1 more source

Fish welfare in a changing world: New developments and current challenges

Journal of Fish Biology, EarlyView.
Abstract The welfare of non‐human animals is central to ethical discussions on animal use, with increasing attention to fish welfare across research, aquaria, aquaculture, and fisheries. This paper reviews current theoretical approaches to animal welfare and recent advances in defining and assessing fish welfare since the seminal paper by Huntingford ...
Sonia Rey Planellas, João L. Saraiva, Eliane Gonçalves‐de‐Freitas, Pablo Arechavala‐Lopez, Bernice Bovenkerk, Michael Breen, Steven J. Cooke, Martin Føre, Lene Northwood, Lars Helge Stien, Sunil Kadri, Chris Noble, Jonatan Nilsson, Fernando Rodriguez, Cosme Salas, Peter Sandøe, Hans van de Vis   +16 more
wiley   +1 more source

Cyclin‐dependent kinase 13 is indispensable for normal mouse heart development

Journal of Anatomy, Volume 246, Issue 4, Page 616-630, April 2025.
Congenital heart disease (CHD) is the most common defect in live births. The role of cyclin‐dependent kinase (CDK13) in cardiogenesis and CHD was studied using a transgenic mouse model (Cdk13tm1b) carrying deletion of exons 3 and 4, causing loss of function.
Qazi Waheed‐Ullah, Anna Wilsdon, Aseel Abbad, Sophie Rochette, Frances Bu'Lock, Asma Ali Saed, Marc‐Phillip Hitz, J. David Brook, Siobhan Loughna   +8 more
wiley   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source