Results 261 to 270 of about 32,246 (328)

Elevated cortisol concentration in preterm sheep fetuses impacts heart development

Experimental Physiology, EarlyView.
Abstract The prepartum rise in cortisol promotes cardiac development and maturation. Here, we investigated the impact of elevated circulating cortisol during mid‐late gestation on cardiac growth and metabolism in fetal sheep. Saline or cortisol (2–3 mg in 4.4 mL/24 h) was infused into the fetal jugular vein from 109 to 116 days gestation (dG, term ...
Reza Amanollahi, Stacey L. Holman, Melanie R. Bertossa, Ashley S. Meakin, Vicki L. Clifton, Kent L. Thornburg, I. Caroline McMillen, Michael D. Wiese, Mitchell C. Lock, Janna L. Morrison   +9 more
wiley   +1 more source

Anatomical Determinants of Papillary Muscle Arrhythmias in Apparently Normal Hearts. [PDF]

Arrhythm Electrophysiol Rev
Rivera S, de la Paz Ricapito M, Ronderos R, Volders PG.   +3 more
europepmc   +1 more source

Atrial fibrillation, sinoatrial and atrioventricular node dysfunction in a mouse model of heart failure with preserved ejection fraction

Experimental Physiology, EarlyView.
Summary of the timeline of characterized events related to atrial fibrilation (AF) and diastolic dysfunction in a mouse heart failure with preserved ejection fraction (HFpEF) model. Three weeks after the initiation of the diet regimen with high fat diet (HFD) and Nω‐nitro‐l‐arginine methyl ester (l‐NAME) in drinking water to induce HFpEF, significantly
Bernadin Ndongson‐Dongmo, Reinhard Bauer, Finn Olav Levy   +2 more
wiley   +1 more source

Computational study of the excitation of human induced pluripotent stem cell‐derived cardiomyocytes

Experimental Physiology, EarlyView.
Abstract Human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CMs) have proven to be a revolutionary advance for tissue engineering, disease modelling, and drug testing and discovery. Computational modelling enables detailed electrophysiological analysis that is otherwise difficult or impossible to achieve under strictly experimental ...
Roshni Shetty, Raffi Samurkashian, Leslie Tung   +2 more
wiley   +1 more source

Suppression of premature ventricular complexes with the PDE5 inhibitor sildenafil: First clinical experience

Experimental Physiology, EarlyView.
Abstract The phosphodiesterase‐5 inhibitor sildenafil suppresses ventricular arrhythmias in a sheep model of drug‐induced long QT. In that study, ventricular arrhythmias were abolished by reducing premature ventricular complexes (PVCs) and delaying PVC onset, thus preventing ‘R‐on‐T’ ventricular tachycardia.
David C. Hutchings, Christopher P. Denton, Luigi Venetucci, Andrew W. Trafford   +3 more
wiley   +1 more source

Orthodromic Atrioventricular Reentry Bradycardia and Tachycardia Caused by an Accessory Pathway in Horses. [PDF]

J Vet Intern Med
Buschmann E, Easton-Jones C, Van Steenkiste G, De Wilde H, Roberts V, Durando M, Decloedt A, Marr C, van Loon G.   +8 more
europepmc   +1 more source

The Impact of Basal Inflammatory Status on Post-CABG Atrial and Ventricular Ectopy and Remodeling Pathways. [PDF]

Medicina (Kaunas)
Cozac DA, Somkereki C, Huțanu A, Nicoara TR, Scridon A.   +4 more
europepmc   +1 more source

The causative role of amyloidosis in the cardiac complications of Alzheimer's disease: a comprehensive systematic review

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Samuel Parker, Andrew F. James, Svetlana Mastitskaya   +2 more
wiley   +1 more source

Prospective in silico trials identify combined SK and K2P channel block as an effective strategy for atrial fibrillation cardioversion

The Journal of Physiology, EarlyView.
Abstract figure legend In silico trials were conducted in 654 virtual patients with atrial fibrillation (AF) to assess the cardioversion efficacy of three pharmacological treatments: single SK and K2P channel block and combined SK+K2P channel inhibition. Left: representative virtual AF patient with the atria inside the torso.
Albert Dasí, Lucas Arantes Berg, Hector Martinez‐Navarro, Alfonso Bueno‐Orovio, Blanca Rodriguez   +4 more
wiley   +1 more source

Electrocardiogram markers predicting ischemic stroke after acute coronary syndrome. [PDF]

Int J Cardiol Cardiovasc Risk Prev
Hurskainen M, Tynkkynen J, Lyytikäinen LP, Lehtimäki T, Nikus K, Hernesniemi J.   +5 more
europepmc   +1 more source