Results 91 to 100 of about 275,052 (295)

Effects of Short-term Renovascular Hypertension and Type 2 Diabetes on Cardiac Functions in Rats

Iranian Journal of Medical Sciences, 2014
Background: The cardiac effects simultaneously occurring during experimental hypertension and diabetes have rarely been investigated. This study aimed at examining the effects of short-term renovascular hypertension and type 2 diabetes on cardiac ...
Ali Akbar Nekooeian, Azadeh Khalili, Mohammad Bagher Khosravi   +2 more
doaj  

Irisin Attenuates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension via Ubiquitin‐Mediated Regulation of ENO1

Advanced Science, EarlyView.
Irisin is a crucial plasma biomarker and promising therapeutic target that reflects disease severity, pulmonary vascular remodeling status and clinical outcome in patients with pulmonary arterial hypertension (PAH). As a novel protective factor, irisin is downregulated in PAH. By ubiquitination, irisin promotes Enolase 1 degradation and suppresses cell
Na Sun, Yong‐Bing Wang, Jing Huang, Run‐Wei Deng, Hui‐Yu He, Lei Gao, Xuan Gao, You‐Li Fan, Yan Cong, Yao‐Lei Guo, Yi‐Qiang Chen, Gui‐Jia Wang, Shao‐Hong Fang, Xia Gu, Bo Yu, Bing‐Xiang Wu   +15 more
wiley   +1 more source

Reinforcing Stromal Cell Spheroid Through Red‐Light Preconditioning for Advanced Vascularization

Advanced Science, EarlyView.
This study presents a novel approach to enhance stromal cell therapy for myocardial infarction by combining OLED‐based photobiomodulation (OPBM) preconditioning with 3D spheroid culture of hADSCs. The engineered spheroids improve angiogenesis, arterialization, and cardiac function in vivo, offering a next‐generation therapeutic strategy to overcome ...
Yu‐Jin Kim, Hyeok Kim, Dong‐Hyun Lee, Yeong Hwan Kim, Jae‐Hyun Park, Woo‐Sup Sim, Jin‐Ju Kim, Kiwon Ban, Soong Ho Um, Hyun Ji Park, Michael E. Davis, Hun‐Jun Park, Suk Ho Bhang   +12 more
wiley   +1 more source

Right ventricular-pulmonary arterial coupling and pulmonary hypertension in hemodialysis: insights into structural cardiac changes and clinical implications

Renal Failure
Objectives This cross-sectional analysis from the CZecking Heart Failure in patients with advanced Chronic Kidney Disease trial (ISRCTN18275480) examined pulmonary hypertension and right ventricular-pulmonary arterial coupling in patients on chronic ...
Kristina Buryskova Salajova, Jan Malik, Lucie Kaiserova, Zuzana Hladinova, Zdenka Hruskova, Simona Janakova, Vladimir Tesar, Satu Sinikka Pesickova, Kristyna Michalickova, Katarina Rocinova, Barbora Szonowska, Anna Valerianova   +11 more
doaj   +1 more source

Left Ventricular Filling and Diastolic Pressure-Volume Relations in the Conscious Dog [PDF]

, 1969
Mark I. M. Noble, Eric N. C. Milne, R. JON GOERKE, Erik Carlsson, R Domenech, Kenneth B. Saunders, Julien I.E. Hoffman   +6 more
openalex   +1 more source

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

Left Ventricular Pressure-Volume Characteristics in Congenital Heart Disease [PDF]

, 1968
M. M. JARMAKANI, Sam B. Edwards, Madison S. Spach, Ramon V. Canent, Matthias Paul, MARY J. HAGAN, Roger C. Barr, Vishnu Jain   +7 more
openalex   +1 more source

Human Nervous System‐Based Biohybrid Robot‐On‐A‐Chip with Sensing Function for Toxicity Screening

Advanced Science, EarlyView.
Human nervous system‐based biohybrid robot‐on‐a chip with eye function as sensing system in addition to brain/motor neuron/muscle functions is proposed. Upon light stimulation, the eye assembloid generates electrophysiological signals, which are transmitted through the cerebral organoid and motor neuron spheroid, inducing muscle movement.
Minkyu Shin, Joungpyo Lim, Seewoo Kim, Sangeun Lee, Wei Wen Su, Jinho Yoon, Jeong‐Woo Choi   +6 more
wiley   +1 more source

Long-term exposure to high-altitude hypoxic environments reduces blood pressure by inhibiting the renin-angiotensin system in rats

Frontiers in Physiology
IntroductionThis study assesses the effects of chronic high-altitude hypoxia on blood pressure regulation in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats, focusing on cardiovascular remodelling, hemodynamic alterations ...
Delong Duo, Junbo Zhu, Mengyue Wang, Xuejun Wang, Ning Qu, Xiangyang Li, Xiangyang Li   +6 more
doaj   +1 more source

EBBP‐Mediated Integrated Stress Response Attenuates Anthracycline‐Induced Cardiotoxicity by Inhibiting the Ferroptosis of Cardiomyocytes

Advanced Science, EarlyView.
EBBP expression is significantly upregulated in DOX‐treated cardiomyocytes. Mechanistically, EBBP interacts with GRP78 to mediate K63‐linked ubiquitination, thereby attenuating the inhibitory GRP78‐PERK interaction and triggering activation of the PERK‐mediated integrated stress response (ISR).
Zilong Chen, Can Chen, Yichen Wu, Yinxue Xia, Ruijie Luo, Jiangcheng Shu, Long Chen, Zhaohui Wang, Cheng Wang, Kai Huang   +9 more
wiley   +1 more source