Results 201 to 210 of about 391,145 (293)

Geometry‐Related Technical Complications After LVAD Implantation: Impact on Device Dysfunction and Clinical Outcomes

open access: yesArtificial Organs, EarlyView.
Preventable geometric failure modes, such as outflow graft kinking and inflow malposition, frequently cause HeartMate 3 dysfunction. This study identifies these complications as key drivers of device‐related morbidity, highlighting the importance of optimized surgical positioning to ensure long‐term device performance and improved clinical outcomes ...
Ali Saad Merzah   +17 more
wiley   +1 more source

Multiple cardiac malformations in a calf

open access: yesAustralian Veterinary Journal, EarlyView.
This paper describes the morphopathological aspects of a case of multiple cardiac malformations in a calf. A two‐day‐old male calf of undefined breed was born with an ectopic heart, presenting with dyspnoea and in lateral recumbency. The owner had repositioned the exposed heart beneath the adjacent skin, which was suclosed, without additional incisions
LA Soares   +7 more
wiley   +1 more source

Decoding neuronal vulnerability: Multidimensional analysis of D1R‐ and D2R‐ medium‐sized spiny neurons in Huntington's disease

open access: yesBrain Pathology, EarlyView.
D1R and D2R MSNs show distinct responses to Huntington's pathology. G&T‐sequencing of pre‐symptomatic MSNs reveals global LINE‐1 downregulation. While D1R‐MSNs display early transcriptomic changes (OXPHOS/translation upregulation) and reduced mutant huntingtin aggregation, D2R‐MSNs exhibit higher nuclear mHTT accumulation and greater CAG somatic ...
Guendalina Bergonzoni   +22 more
wiley   +1 more source

Circulating Musclin is associated with skeletal muscle function and subclinical cardiac dysfunction in patients with cancer

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Musclin (osteocrin) is a skeletal muscle‐derived peptide that has been implicated in cardioprotective signalling pathways. Its relevance in cancer patients, who frequently experience muscle wasting and cardiotoxicity, remains unclear. This study aimed to determine whether circulating Musclin levels reflect functional capacity and
Jannek Brauer   +5 more
wiley   +1 more source

A comprehensive review of cancer‐induced cardiac wasting

open access: yesBritish Journal of Pharmacology, EarlyView.
Cancer is frequently accompanied by cachexia, a systemic syndrome characterized by progressive loss of skeletal muscle mass, with or without loss of fat mass. Increasing evidence indicates that cancer can also induce cardiac muscle wasting, which is associated with structural cardiac remodelling, impaired contractile function and the development of ...
Alessia Lena   +5 more
wiley   +1 more source

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