Results 171 to 180 of about 181,298 (332)

Role of Potassium in Cyclopropane-Epinephrine Ventricular Tachycardia [PDF]

open access: bronze, 1964
Larry D. Davis   +2 more
openalex   +1 more source

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

open access: yesMed Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin   +8 more
wiley   +1 more source

Identifying Pediatric Drug Safety Knowledge Gaps: An Integrated Approach Leveraging Real‐World Data, a Biomedical Knowledge Base, and Postmarketing Surveillance Data

open access: yesPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView.
ABSTRACT Background Drug safety has historically been understudied in pediatric populations, rendering them “therapeutic orphans.” Pediatric drug indications and dosages are often inferred by extrapolating safety, efficacy, and dosing data from adult studies, leading to widespread off‐label use.
Saurabh Rahurkar   +8 more
wiley   +1 more source

Initial investigations into single nucleotide polymorphisms and their association with QTc and left ventricular function in peripartum cardiomyopathy

open access: yes
European Journal of Heart Failure, EarlyView.
Gasnat Shaboodien   +12 more
wiley   +1 more source

Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review

open access: yesPhytotherapy Research, EarlyView.
ABSTRACT The preclinical evidence for the safety of ashwagandha (Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports.
Elizabeth M. Williamson, Thomas Brendler
wiley   +1 more source

The use of low‐dose dexmedetomidine constant rate infusion to stabilise blood glucose in a domestic ferret (Mustela putorius furo) with insulinoma undergoing sevoflurane anaesthesia

open access: yesVeterinary Record Case Reports, EarlyView.
Abstract A 5.5‐year‐old, male domestic ferret (Mustela putorius furo) diagnosed with insulinoma was presented for a dental procedure under general anaesthesia. In insulinoma patients, it is essential to avoid hypoglycaemia. In other species, constant rate infusion of dexmedetomidine has been reported to sustain adequate blood glucose by inhibiting ...
Anika R. Schiele   +3 more
wiley   +1 more source

Isorhythmic atrioventricular dissociation during anaesthesia in a cat

open access: yesVeterinary Record Case Reports, EarlyView.
Abstract A 10‐year‐old, male, neutered domestic shorthair cat with suspected hypertrophic cardiomyopathy was referred for cystotomy to remove uroliths present in its urinary bladder. Fifteen minutes after induction of general anaesthesia, atrioventricular dissociation was noted on the electrocardiogram with similar atrial and ventricular firing rates ...
Gemma Padrosa Sala   +3 more
wiley   +1 more source

ECG‐TransCovNet: A hybrid transformer model for accurate arrhythmia detection using Electrocardiogram signals

open access: yesCAAI Transactions on Intelligence Technology, EarlyView.
Abstract Abnormalities in the heart's rhythm, known as arrhythmias, pose a significant threat to global health, often leading to severe cardiac conditions and sudden cardiac deaths. Therefore, early and accurate detection of arrhythmias is crucial for timely intervention and potentially life‐saving treatment.
Hasnain Ali Shah   +4 more
wiley   +1 more source

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