Results 231 to 240 of about 38,554 (353)

Small‐conductance Ca2⁺‐activated K⁺ channels in cardiac excitation–contraction coupling: Bridging mitochondria, sarcolemma and antiarrhythmic therapy

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Mitochondrial SK channel enhancement reduces cardiac arrhythmia trigger. Spontaneous sarcoplasmic reticulum (SR) Ca2+ release via hyperactive RyR2s underlies an increased arrhythmia trigger, promoting early and delayed afterdepolarizations during stress. Hyperactive RyR2s causes rise in cytosolic [Ca2+] during diastole. Clearance
Dmitry Terentyev   +7 more
wiley   +1 more source

Impact of ventricular tachycardia ablation in the setting of electrical storm based on patient risk profile. [PDF]

open access: yesEuropace
Ninni S   +16 more
europepmc   +1 more source

MP-470544-002 VENTRICULAR TACHYCARDIA ORIGINATING FROM PARA HISIAN LOCATION: ELECTROCARDIOGRAPHIC AND CATHETER ABLATION CHARACTERISTICS [PDF]

open access: bronze
Adriana Tokich   +7 more
openalex   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière   +6 more
wiley   +1 more source

Reduced cardiovascular mortality at moderate altitude: a putative role of physical activity and body mass

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Benefits of performing physical exercise at moderate altitude. At moderate altitude, increased resting metabolic rate and physical exertion promote physical fitness and exercise tolerance, whereas hypoxia suppresses appetite and elicits adaptations that increase tissue O2 delivery while augmenting O2‐independent ATP production ...
Robert T. Mallet   +6 more
wiley   +1 more source

Human‐derived cardiac‐neural microtissues reveal catecholaminergic polymorphic ventricular tachycardia is also a disease of the sympathetic neuron

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Schematic diagram illustrating the proposed pathway in which regulatory defects might occur in sympathetic neurons derived from hiPSC in catecholaminergic polymorphic ventricular tachycardia (CPVT). Specifically, enhanced calcium transients appeared to derive from three sources: enhanced membrane excitability (due to loss of ...
Ni Li   +19 more
wiley   +1 more source

Safety of ventricular tachycardia ablation under deep sedation with propofol and fentanyl. [PDF]

open access: yesJ Interv Card Electrophysiol
Maslova V   +11 more
europepmc   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò   +18 more
wiley   +1 more source

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