Results 101 to 110 of about 78,227 (238)

Activation of peripheral NOP receptors reduces periorbital mechanical allodynia evoked by CGRP in mice

British Journal of Pharmacology, EarlyView.
Background and Purpose Migraine is a neurovascular disorder largely mediated by calcitonin gene‐related peptide (CGRP). This study explores the role of the nociceptin/orphanin FQ (N/OFQ)–N/OFQ receptor (NOP) system in CGRP‐induced periorbital mechanical allodynia (PMA) in mice.
Chiara Sturaro, Pietro Pola, Michela Argentieri, Alessia Frezza, Matilde Marini, Francesco De Logu, Valentina Albanese, Marie Soukupova, Davide Malfacini, Nurulain T. Zaveri, Romina Nassini, Dane D. Jensen, Pierangelo Geppetti, Girolamo Calò, Chiara Ruzza   +14 more
wiley   +1 more source

Systematic profiling reveals broad G protein coupling and context‐dependent modulation of cyclic AMP by the orphan receptor GPR139

British Journal of Pharmacology, EarlyView.
Background and Purpose G protein‐coupled receptors (GPCRs) are major drug targets, yet many orphan receptors remain poorly characterized. GPR139 has been implicated in CNS disorders, including schizophrenia and depression, but its signalling mechanisms remain unclear.
Boris Trapkov, Hans Bräuner, Alexander Sebastian Hauser   +2 more
wiley   +1 more source

Trabajadores con carretillas junto a la Plataforma de Venus

, 1940
I.O. "142.", "XXX-60", "3032". Inscripción en la guarda: "Chichén Itzá Yuc.", "Zona Arqueológica", "Prehispánicos", "Tomo XXX-60". Plataforma de Venus, V.F.

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Selective excitatory effects of γ‐glutamyl‐glycine, a glutathione metabolite, on GluN1 NMDA and mGlu5 receptors impacting synaptic plasticity

British Journal of Pharmacology, EarlyView.
Background and Purpose Gamma‐glutamyl dipeptides are essentially produced after glutathione (GSH) degradation. While several γ‐glutamyl dipeptides have been detected in different organs and body fluids, their biological activity remains elusive. This is the case for γ‐Glutamyl‐Glycine (γ‐Glu‐Gly) which has been found in different brain areas.
Sandro Andreu, Victoria Gizzi, Ugo Pasco, Fatiha Sebih, Yattou Zitouni, Pablo Jimenez, Valérie Rolland, Alain Chavanieu, Sébastien Estaran, Matthieu Rousset, Thierry Cens, Guillaume Cazals, Pierre Charnet, Janique Guiramand, Catherine Cohen‐Solal, Claudine Ménard, Marie‐Céleste de Jésus Ferreira, Nathalie Chevallier, Sonia Cantel, Michel Vignes, Julien Roussel   +20 more
wiley   +1 more source

Trabajos de reconstrucción de la plataforma de Venus, vista general

, 1940
I.O. "149", "XXX-66", "3038". Inscripción en la guarda: "Chichén Itzá Yuc.", "Zona Arqueológica", "Prehispánicos", "Tomo XXX-66". Plataforma de Venus, V.F.

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Positive modulation of glucagon‐like peptide 1 (GLP‐1) receptor by endogenous haemorphins with implications in glucose metabolism and diabetes

British Journal of Pharmacology, EarlyView.
Haemorphins act on GLP‐1 receptor (GLP‐1R) activity and signalling in a positive allosteric manner. This leads to potentiated GLP‐1‐mediated activity and signalling, as well as insulin synthesis, which may have implications for glucose metabolism and, thereby, diabetes and obesity. (The graph was created in BioRender.com).
Farheen Badrealam Khan, Rwdah Mohamed Alameri, Yasir S. Raouf, Damien Maurel, Naiem Ahmad Wani, Anatoliy Shmygol, Irfa Anwar, Heng B. See, Elizabeth K. M. Johnstone, Elodie Dupuis, Eric Trinquet, Kevin D. G. Pfleger, Emilia Oueis, Mohammed Akli Ayoub   +13 more
wiley   +1 more source

Trabajadores restauran las escalinatas de la Plataforma de Venus

, 1940
I.O. "168", "XXX-82", "3057". Inscripción en la guarda: "Chichén Itzá Yuc", "Zona arqueológica", "Prehispánicos", "Tomo XXX-82". Plataforma de Venus, V.F.

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Mass Mobilising for Climate Action: A Member‐Driven Innovation Process in a Nongovernmental Organisation

Creativity and Innovation Management, EarlyView.
ABSTRACT Environmental organisations (EOs) are not‐for‐profit organisations that contribute to responsible innovation (RI) efforts to mitigate the climate crisis as central catalysts in society. While the RI discourse in management research acknowledges that collaboration between a broad variety of actors is necessary to foster climate action, so far ...
Ida Raunkjær, Patricia Wolf, Szabolcs Dezso Fabian   +2 more
wiley   +1 more source

Hombres colocan piedras al reconstruir la Plataforma de Venus

, 1940
I.O. "148", "XXX-65", "3037". Inscripción en la guarda: "Chichén Itzá Yuc.", "Zona Arqueológica", "Prehispánicos", "Tomo XXX-65". Plataforma de Venus, V.F.

core  

AFF4 Loss Compromises Osteogenesis of Orofacial Mesenchymal Stem Cells During Alveolar Bone Repair via AMPK‐Mediated Mitophagy

Cell Proliferation, EarlyView.
Compromised alveolar socket healing following tooth extraction upon Aff4 knockout is caused by suppressed osteogenic capacity of orofacial mesenchymal stem cells, which results from defective AMPK‐mediated mitophagy. ABSTRACT Repair of maxillofacial bone defects presents significant clinical challenges.
Li Zhu, Shuo Chen, Guowen Luo, Tingyue Zhang, Hengyi Lin, Yiling Chen, Chenchen Zhou, Shujuan Zou   +7 more
wiley   +1 more source