Results 191 to 200 of about 281,101 (262)

Physiology of nitrogen: A life or death matter

open access: yesExperimental Physiology, EarlyView.
Abstract With each breath, four out of every five molecules we inspire are nitrogen (N2), since this gas constitutes ∼80% of the atmospheric air that surrounds us. Despite its abundance and unlike molecular oxygen, N2 has traditionally held less appeal among physiologists given its lack of reactivity and corresponding inability to support combustion or
Damian M. Bailey   +2 more
wiley   +1 more source

Sphingosine‐1‐phosphate activates LRRC8 volume‐regulated anion channels through Gβγ signalling

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Sphingosine‐1‐phosphate (S1P) binds to Gi protein‐coupled receptor S1PR1. Upon S1PR1 activation, Gβγ is released from the Gαi‐Gβγ heterotrimer, allowing it to recruit phospholipase Cβ (PLCβ) to the plasma membrane. PLCβ cleaves phosphatidylinositol‐4,5‐bisphosphate (PIP2) into inositol trisphosphate (IP3) and diacylglycerol (DAG).
Yulia Kostritskaia   +4 more
wiley   +1 more source

Single‐cell transcriptomics of human organoid‐derived enteroendocrine cell populations from the small intestine

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Human intestinal organoids were genetically modified to express a fluorescent protein in enteroendocrine cells (EECs), which were then separated by flow cytometry and analysed by single‐cell RNA sequencing. High numbers of human EECs were thereby available for cluster analysis and differential gene expression, revealing ...
Christopher A. Smith   +7 more
wiley   +1 more source

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