Results 191 to 200 of about 300,010 (299)

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, Volume 13, Issue 24, 27 April 2026.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

Electric Fields and Waves in the Venus Nightside Magnetosphere. [PDF]

Space Sci Rev
Mozer FS, Agapitov AV, Bale SD, Bonnell JW, Pulupa M, Quinn T, Voshchepynets A.   +6 more
europepmc   +1 more source

Targeting PRKCN, an Essential Driver Orchestrating mTOR‐IRF4 Axis Independently of Kinase Activity, in Multiple Myeloma

Advanced Science, Volume 13, Issue 21, 13 April 2026.
Constitutive PRKCN expression is driven by super‐enhancers and modulated by NF‐κB signaling in multiple myeloma (MM). PRKCN activates mTORC1/2‐IRF4 signaling axis and favors tumor cell growth independently of its kinase activity. IRF4 reciprocally promotes PRKCN transcription, creating a feed‐forward loop.
Koukou Tang, Dongpeng Jiang, Peng Ke, Xiaosen Bian, Lili Zhang, Ying Zhang, Tingting Zhu, Weiwei Qu, Wenhui Qi, Yang Xu, Chengcheng Fu, Depei Wu, Jianhong Chu   +12 more
wiley   +1 more source

The role of acyl cycling in endogenous G protein localization. [PDF]

J Biol Chem
Jang W, Senarath K, Lu S, Solis GP, Katanaev VL, Lambert NA.   +5 more
europepmc   +1 more source

Tracking tau and cellular responses in human iPSC‐microglia: from uptake to seedable secretion, including in extracellular vesicles

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Microglia have been implicated in the templated spread of tau aggregates in tauopathies through mouse studies. However, it is unclear whether these findings translate to human disease. METHODS We challenged human induced pluripotent stem cell (iPSC)‐derived microglia‐like‐cells (iMGL) with monomeric and fibrillar recombinant tau ...
Maria Kreger Karabova, Anna del Ser‐Badia, Anne Hedegaard, Sam J. Washer, Zeynep Baykam, Darragh P. O'Brien, Iolanda Vendrell, Svenja S. Hester, Roman Fischer, Errin Johnson, Charlotte E. Melia, Teige R. S. Matthews‐Palmer, Rishi Matadeen, Alessia Santambrogio, Michael A. Metrick II, Michele Vendruscolo, Sophie Keeling, Kimberly Ai Xian Cheam, William A. McEwan, Kenneth S. Kosik, Theresa A. Day, William S. James, Sally A. Cowley   +22 more
wiley   +1 more source

DEX in near Earth orbit in light of Venus Orbiter Dust Experiment. [PDF]

Sci Rep
Pabari J, Nambiar S, Singh R, Jitarwal S, Bhardwaj A, Praneeth SMK, Shah B, Suthar P, Pandya S, Rami J, Kumar D, Singh VK, Khandekar R, Singh RK, Sahu A, Adalja H, Patel A.   +16 more
europepmc   +1 more source

In Silico and In Vitro Antiurolithic Effect of Extracts, Fractions, and Isolated Compounds From Eugenia mattosii

Chemistry &Biodiversity, Volume 23, Issue 4, April 2026.
ABSTRACT Urolithiasis, a condition characterized by the formation of calcium oxalate stones in the urinary tract, remains a significant clinical challenge due to the limited availability of effective preventive therapies. This study investigated the antiurolithic potential of different preparations from Eugenia mattosii, a plant rich in phenolic ...
Bianca Letícia Maciél, Luma Da Silva Portella, Camile Cecconi Cechinel‐Zanchett, Anelize Dada, Rita de Cássia Vilhena da Silva, Anelise Felício Macarini, Valdir Cechinel Filho, Priscila de Souza, Giovana Vechi   +8 more
wiley   +1 more source

Venus

, 2011
[ES] Definición del término Venus en el diccionario Dicter. [EN] Definition of the word Venus in the dictionary Dicter.
openaire   +1 more source

Recanalization of Thrombosed Atrial Flow Regulator in Failing Fontan: A Bridge to Transplant

Catheterization and Cardiovascular Interventions, Volume 107, Issue 5, Page 1380-1383, April 1, 2026.
ABSTRACT We report the case of a 10‐year‐old boy (41 kg, 133 cm) with hypoplastic left heart syndrome (mitral and aortic atresia), who underwent staged palliation: Norwood‐Sano at 6 days, Glenn at 7 months, and Fontan completion at 3 years using a 16 mm non‐fenestrated extracardiac Gore‐Tex conduit.
Raymond N. Haddad, Estibaliz Valdeolmillos, Emre Belli, Sébastien Hascoët   +3 more
wiley   +1 more source

Microaxial Flow Pump-Protected Percutaneous Pulmonary Valve Replacement in High-Risk Patients With Severe Left Ventricular Dysfunction. [PDF]

JACC Case Rep
Schleiger A, Moosmann J, Lanmüller P, Potapov E, Berger F, Kramer P.   +5 more
europepmc   +1 more source