Results 61 to 70 of about 123 (118)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, Volume 20, Issue 6, Page 1556-1590, June 2026.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Relationship of the gene pool of the Khants with the peoples of Western Siberia, Cis-Urals and the Altai-Sayan Region according to the data on the polymorphism of autosomic locus and the Y-chromosome. [PDF]

Vavilovskii Zhurnal Genet Selektsii, 2023
Kharkov VN, Kolesnikov NA, Valikhova LV, Zarubin AA, Svarovskaya MG, Marusin AV, Khitrinskaya IY, Stepanov VA.   +7 more
europepmc   +1 more source

3D‐Printable, Honeycomb‐Inspired Tissue‐Like Bioelectrodes for Patient‐Specific Neural Interface

Advanced Materials, Volume 38, Issue 31, 2 June 2026.
3D printed MRI‐compatible tissue‐like neural electrodes tailored to individual gyral patterns. This honeycomb‐inspired printable gel electrode (HiPGE) employs a bioinspired architecture with soft hydrogels, engineered to match the softness of brain tissue.
Marzia Momin, Luyi Feng, Xiaoai Chen, Salahuddin Ahmed, Basma AlMahmood, Li‐Pang Huang, Jiashu Ren, Xinyi Wang, Hyunjin Lee, Samuel R. Cramer, Nanyin Zhang, Sulin Zhang, Tao Zhou   +12 more
wiley   +1 more source

Causal Prediction of TP53 Variant Pathogenicity Using a Perturbation‐Informed Protein Language Model

Advanced Science, Volume 13, Issue 34, 19 June 2026.
A TP53‐specific predictor, CaVepP53, is developed by fine‐tuning ESMC on experimentally validated variants, quantifying pathogenicity via Euclidean distances. It outperforms general‐purpose models and extends to five cancer genes, enabling interpretable variant classification for precision medicine.
Huiying Chen, Yang Zhao, Boqiang Hu, Wuke Wang, Minfang Song, Annabeth Xinyu Zhao, Xiangyang Li, Gefei Wang, Yanfen Wang, Weiyan Zheng, Xinpeng Zhang, Xia Lin, Yanbin Yin, Xingxu Huang, Jinfang Zheng, Tingbo Liang   +15 more
wiley   +1 more source

Influence of MC1R Gene Variants on Coat Color of Indicine Cattle Breeds

Animal Genetics, Volume 57, Issue 3, June 2026.
ABSTRACT Indicine cattle display a broad range of coat colors, representing a relevant and breed‐defining trait required for registration in breeder association. Among the genes involved in pigmentation, MC1R stands out for modulating the synthesis of melanin‐related proteins and remains poorly explored in indicine cattle breeds. Therefore, we aimed to
Silel V. S. A. Maciel, Ingrid P. P. Oliveira, Beatriz B. Senes, Carolaine J. S. Santana, Jackeline S. Alves, Edilane A. da Silva, Fernando O. Franco, Bárbara C. F. da Silva, Fernando C. Cairo, Frederico C. Cairo, Aníbal E. Vercesi‐Filho, Raphael B. Costa, Gregório M. F. de Camargo   +12 more
wiley   +1 more source

Functional Segregation of Epileptogenicity within the Human Amygdala

Annals of Neurology, Volume 99, Issue 6, Page 1598-1612, June 2026.
Objective In temporal lobe epilepsy (TLE), the amygdala in the epileptogenic network is underestimated compared to other regions such as the hippocampus. Recent advances in anatomical neuroimaging and stereoelectroencephalography (SEEG) signal analyses could help better understand the involvement of the different amygdala nuclei in the genesis of ...
Odile Feys, Julia Makhalova, Samuel Medina Villalon, Maria Fratello, Hugo Dary, Stanislas Lagarde, Francesca Pizzo, Agnès Trébuchon, Maxime Guye, Jean‐Philippe Ranjeva, Romain Carron, Didier Scavarda, Christian‐George Bénar, Bernard Giusiano, Fabrice Bartolomei   +14 more
wiley   +1 more source

MOG Antibody‐Associated Optic Neuritis Masquerading as Traumatic Optic Neuropathy Following Cranial Trauma: A Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) is an autoimmune disorder characterized by demyelination of the central nervous system. It can impact the optic nerves, spinal cord, brain parenchyma, and brainstem, resulting in various clinical presentations such as acute disseminated encephalomyelitis (ADEM), optic ...
Yuxian Shi, Xin Qi, Boding Tong, Jing Deng, Yating Liu, Yunping Li   +5 more
wiley   +1 more source

Varafolkloorsetelt vokaalzhanridelt lauluni

Mäetagused, 1998
The Estonian folk song is usually divided into two main historical-stylistical strata: the runo songs (songs in runo verse form, also called Kalevala-metre songs, alliterative songs etc.) and the newer songs with an end-rhyme and strophic form.
Ingrid Rüütel
doaj  

Effects of Different SNP Calling and Sequence Mapping Choices on the Inference of Genetic Architecture Underlying Migration Tendency

Ecology and Evolution, Volume 16, Issue 6, June 2026.
We re‐analysed RAD‐Seq data from brown trout using a conspecific reference genome and alternative SNP pipelines. Population structure was robust across methods, but using the brown trout reference improved detection of biologically relevant outlier SNPs. ABSTRACT Genome‐wide association studies with identification of biologically relevant genes rely on
Giovanna Mottola, Frank Panitz, Tuomas Leinonen, Alexandre Lemopoulos, Anssi Vainikka   +4 more
wiley   +1 more source

KCNJ4 variants disrupt inward‐rectifier potassium channel function and cause refractory epilepsy

Epilepsia, Volume 67, Issue 6, Page 3199-3210, June 2026.
Abstract Objective Epilepsy is a common neurological disorder with a strong genetic basis, most frequently arising from ion channel dysfunction. Although multiple inwardly rectifying potassium (Kir) channels have been implicated in epileptogenesis, the contribution of KCNJ4, which encodes the Kir2.3 channel, has not previously been established in human
Hu Pan, Deng Liu, Wuhen Xu, Yang Li, Juanli Hu, Oppermann Henry, Alexander Fuchs, Rami Abou Jamra, Zhen Liu, Mei He, Yuanlu Chen, Shengnan Wu, Xiaohuan Dong, Yiqiao Chen, Pengchao Wang, Weiyue Gu, Han Jing, Yabing Tang, Ya‐Jie Wang, Xiao Mao, Neng Xiao   +20 more
wiley   +1 more source