Results 211 to 220 of about 2,281 (257)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Blockchain-driven smart contract with key exchange protocol for secure device-to-device communication using verkle tree K-ary structures. [PDF]

Sci Rep
Simbu A, Nandakumar S, Saravanan K.
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Lightweight ECC-Based Self-Healing Federated Learning Framework for Secure IIoT Networks. [PDF]

Sensors (Basel)
Salim MM, Naaz F, Choi K.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

GeoCross: A Privacy-Preserving and Fine-Grained Authorization Scheme for Cross-Chain Geological Data Sharing. [PDF]

Sensors (Basel)
Lin L, Feng B, Jing P.
europepmc   +1 more source

Federated reinforcement learning-driven multi-task optimization for robust and ethical edge internet of things security. [PDF]

Sci Rep
Li Y, Wang H, Xu G.
europepmc   +1 more source

The optimization of vocal music teaching by integrating the STEAM concept with the intelligent recommendation system. [PDF]

Sci Rep
Su F, Guo Q.
europepmc   +1 more source

A Framework for Budget-Constrained Zero-Day Cyber Threat Mitigation: A Knowledge-Guided Reinforcement Learning Approach. [PDF]

Sensors (Basel)
Basak M, Shin GY.
europepmc   +1 more source