Results 51 to 60 of about 1,008,051 (261)
Agritech, 2021 Tanaman paria atau pare (Momordica charantia L.) termasuk salah satu tanaman sayur yang berpotensi komersil bila dibudidayakan secara intensif dalam skala agribisnis Tanaman ini hanya di tanam sebagai usaha sambilan mengingat rendahnya permintaan dari ...
Fawzy Muhammad Bayfurqon +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Jurnal Sains Sosial dan Humaniora, 2021 Tujuan dari penelitian ini adalah untuk menganalisis variabel demografi yang berpengaruh terhadap probabilitas (peluang) tinggi rendahnya cerai hidup wanita di Pulau Sumatera.
Angga Setyawan
doaj +1 more source
Vertical restraints and competition policy [PDF]
, 1996 This report considers the private and social welfare effects of vertical restraints - whereby contractual arrangements between suppliers (manufacturers) and distributors (retailers) extend beyond simple arms-length pricing.
Dobson, Paul +3 more
core
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Vertical integration, market foreclosure and quality investment [PDF]
, 2006 Incentives to vertically integrate are studied in an industry where downstream firms are vertically differentiated. Vertical integration by one of the firms increases production costs for the rival.
Roberto Hernan +3 more
core +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source