Results 31 to 40 of about 1,100,883 (182)

Genetics of Progressive Supranuclear Palsy: A Review

Journal of Parkinson’s Disease, 2021
Progressive supranuclear palsy (PSP) is an atypical parkinsonism with prominent 4R-tau neuropathology, and the classical clinical phenotype is characterized by vertical supranuclear gaze palsy, unprovoked falls, akinetic-rigid syndrome and cognitive ...
Yafei Wen, Yafang Zhou, Bin Jiao, Lu Shen   +3 more
doaj   +1 more source

Clinical Approach to Supranuclear Brainstem Saccadic Gaze Palsies

Frontiers in Neurology, 2017
Failure of brainstem supranuclear centers for saccadic eye movements results in the clinical presence of a brainstem-mediated supranuclear saccadic gaze palsy (SGP), which is manifested as slowing of saccades with or without range of motion limitation of
Alexandra Lloyd-Smith Sequeira, John-Ross Rizzo, John-Ross Rizzo, Janet C. Rucker, Janet C. Rucker   +4 more
doaj   +1 more source

Measuring saccades in patients with Niemann-Pick type C: A comparison between video-oculography and a novel eye tracking test based on continuous psychophysics

Clinical Parkinsonism & Related Disorders, 2022
Introduction: Vertical supranuclear gaze palsy is a key feature of Niemann-Pick type C (NP-C) and is commonly quantified using video-oculography (VOG). VOG requires sitting still for long times and performing specific tasks, thus it can be challenging or
A. Grillini, L.H. Koens, G. Lizaitiene, F. Lange, F.W. Cornelissen, M.A.J. Tijssen   +5 more
doaj   +1 more source

Diplopia and Vertical Gaze Palsy with Punctate Brain Stem Infarct

Graduate Medical Education Research Journal, 2019
Mentor: Sachin Kedar Program: Neurology Objective: To describe the clinical features, MRI findings, and neuroanatomy of a patient with a punctate brainstem stroke.
Jamison Hofer, Sachin Kedar, T. Scott Diesin, Daniel Zhou, Nicholas Swingle   +4 more
doaj   +1 more source

Progressive Supranuclear Palsy with Wall-Eyed Bilateral Internuclear Ophthalmoplegia Syndrome: Authors’ Second Case

Case Reports in Neurology, 2019
Wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) syndrome has previously been reported in only 2 patients with progressive supranuclear palsy (PSP). Herein, we report a third case of WEBINO syndrome with PSP.
Hideyuki Matsumoto, Tatsurou Inaba, Toshiyuki Kakumoto, Ryoji Miyano, Naohiro Uchio, Yasuhisa Sakurai   +5 more
doaj   +1 more source

Clinical and Genetic Characteristics of Mexican Patients with Juvenile Presentation of Niemann-Pick Type C Disease

Case Reports in Neurological Medicine, 2014
Niemann-Pick type C disease (NPC) is a rare lysosomal disease with a protean presentation, ranging from a fatal neonatal course with visceromegaly to an adult presentation with only neurological or psychiatric symptomatology.
Raul E. Piña-Aguilar, Aurea Vera-Loaiza, Oscar F. Chacón-Camacho, Juan Carlos Zenteno, Lilia Nuñez-Orozco, Yuritzi Santillán-Hernández   +5 more
doaj   +1 more source

Artery of Percheron infarction: A case report and literature review

Radiology Case Reports, 2021
The artery of Percheron (AOP) represents a rare anatomic variant of the posterior circulation. It is a solitary trunk that provides bilateral arterial supply to the rostral midbrain and paramedian thalamus.
Juna Musa, MD Msc, Masum Rahman, MD, Ali Guy, Clinical assistant professore, Erisa Kola, MD, Angela Guy, MD, Fjolla Hyseni, MD, Anisa Cobo, MD, Kristi Saliaj, MD, Fiona Bushati, MD, Ilir Ahmetgjekaj, Phd   +9 more
doaj   +1 more source

Combined Supranuclear Horizontal and Vertical Gaze Palsy in a Bilateral Thalamic Infarction.

Equilibrium Research, 1999
A 64-year-old man developed bilateral exotropia in the primary position after a stroke. CT revealed bilateral thalamic infarction. The saggital view of MRI disclosed that the lesion extended from the thalamus toward the rostral portion of the mesencephalon, in the territory of the paramedian thalamic arteries.Occlusion of these arteries may cause ...
Yokota, Jun-ichi, Kosaka, Kenji, Amakusa, Tairiku   +2 more
openaire   +2 more sources

Association of MRI Measures With Disease Severity and Progression in Progressive Supranuclear Palsy

Frontiers in Neurology, 2020
Objective: To verify the association of midbrain-based MRI measures as well as cortical volumes with disease core features and progression in patients with Progressive Supranuclear Palsy (PSP).Methods: Sixty-seven patients (52.2% with Richardson's ...
Marina Picillo, Filomena Abate, Sara Ponticorvo, Maria Francesca Tepedino, Roberto Erro, Daniela Frosini, Eleonora Del Prete, Paolo Cecchi, Mirco Cosottini, Roberto Ceravolo, Gianfranco Di Salle, Francesco Di Salle, Fabrizio Esposito, Fabrizio Esposito, Maria Teresa Pellecchia, Renzo Manara, Paolo Barone   +16 more
doaj   +1 more source

A longitudinal study of motor, oculomotor and cognitive function in progressive supranuclear palsy

, 2013
ObjectiveWe studied the annual change in measures of motor, oculomotor and cognitive function in progressive supranuclear palsy. This had twin objectives, to assess the potential for clinical parameters to monitor disease progression in clinical trials ...
Boyd C P Ghosh, Roger H. S. Carpenter, Roger H S Carpenter, James B. Rowe, Carpenter, Roger H.S., Rowe, James B., James B Rowe, Ghosh, Boyd C.P., Boyd C. P. Ghosh   +8 more
core   +1 more source