Results 121 to 130 of about 117,562 (243)

Pharmacokinetics and Safety of Fenofibrate in Participants with Mild Hepatic Impairment or with Advanced Fibrosis due to Metabolic‐Associated Fatty Liver Disease

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract Fenofibrate is contraindicated in patients with advanced hepatic fibrosis due to limited clinical data. We evaluated the pharmacokinetics and safety of fenofibrate in participants with mild hepatic impairment (phase 1 study) or advanced fibrosis due to metabolic‐associated fatty liver disease (MAFLD; phase 2a study).
Islam R. Younis   +5 more
wiley   +1 more source

Effects of Hepatic or Renal Impairment on Pharmacokinetics of Fruquintinib

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract Fruquintinib (FRUZAQLATM) is a highly selective tyrosine kinase inhibitor of all three vascular endothelial growth factor receptors (‐1, ‐2, and ‐3). Two Phase 1, open‐label, single‐dose studies investigated the impact of hepatic or renal impairment on the pharmacokinetics and tolerability of fruquintinib.
Martha Gonzalez   +8 more
wiley   +1 more source

Positional Convergence Spasm: A Case Report. [PDF]

open access: yesCureus
Mamardashvili G   +3 more
europepmc   +1 more source

Maltreatment and parenting in youth with primary and secondary callous‐unemotional traits: Anxiety matters

open access: yesJCPP Advances, EarlyView.
We investigated latent classes of typically developing youth with subgroups of primary and secondary callous‐unemotional youth. Sex differences were also explored. The groups were then compared on maltreatment histories (abuse and neglect) and experiences of parenting.
Jessica J. Todorov   +21 more
wiley   +1 more source

Vestibular migraine: course of symptoms during a four-year follow-up. [PDF]

open access: yesFront Neurol
Celebisoy N   +13 more
europepmc   +1 more source

Effects of a two‐night hospitalization program as a specific health guidance on obesity and cardiovascular disease risk factors

open access: yesJournal of General and Family Medicine, EarlyView.
Abstract Background To assess the effects of a two‐night hospitalization program conducted at our hospital as part of a domestic health guidance system. This program is designed for lifestyle modification within a health checkup framework for metabolic syndrome. Methods This is a single‐center, retrospective observational study. We reviewed the medical
Maki Okazaki   +5 more
wiley   +1 more source

Distinctive clinical features of early and late-onset Ménière's disease. [PDF]

open access: yesFront Neurol
Lin J   +6 more
europepmc   +1 more source

Critical mistakes in managing chronic constipation in the older person and how to avoid them: A narrative review

open access: yesJournal of General and Family Medicine, EarlyView.
Abstract Objectives This narrative review identifies pitfalls in managing constipation in older adults and provides evidence‐based recommendations to avoid them. Methods A selective literature search was conducted across electronic databases (PubMed, MEDLINE, Embase, and Cochrane Library) to identify relevant publications on constipation management in ...
Madunil Niriella   +3 more
wiley   +1 more source

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