Results 121 to 130 of about 185,606 (358)

Can We Really Believe This Platelet Count?

American Journal of Hematology, EarlyView.
James Manning, Simona Deplano, Ketan Patel, Barbara J. Bain   +3 more
wiley   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Precision Balance Assessment in Parkinson’s Disease: Utilizing Vision-Based 3D Pose Tracking for Pull Test Analysis

Sensors
Postural instability is a common complication in advanced Parkinson’s disease (PD) associated with recurrent falls and fall-related injuries. The test of retropulsion, consisting of a rapid balance perturbation by a pull in the backward direction, is ...
Nina Ellrich, Kasimir Niermeyer, Daniela Peto, Julian Decker, Urban M. Fietzek, Sabrina Katzdobler, Günter U. Höglinger, Klaus Jahn, Andreas Zwergal, Max Wuehr   +9 more
doaj   +1 more source

Safety and pharmacokinetics of a novel potent GABA analogue crisugabalin in Chinese subjects with various degrees of renal impairment

British Journal of Clinical Pharmacology, EarlyView.
Aims Crisugabalin is a novel calcium channel α2δ subunit ligand and a highly selective oral gamma‐aminobutyric acid (GABA) analogue developed for the treatment of diabetic peripheral neuropathic pain (DPNP) and postherpetic neuralgia (PHN). This study investigated pharmacokinetic properties and safety of crisugabalin in subjects with renal impairment ...
Shibeilei Lin, Ye Wang, Chao Hu, Yanhuan Feng, Xi Tang, Ping Fu, Jia Miao   +6 more
wiley   +1 more source

A mobile electrical stimulator for therapeutic modulation of the vestibular system — design, safety, and functionality

Frontiers in Neurology
Low-intensity noisy galvanic vestibular stimulation (nGVS) is a promising non-invasive treatment for enhancing vestibular perceptual performance and postural control in patients with chronic vestibular hypofunction. However, this approach has so far been
Sandra Kollmansperger, Julian Decker, Julian Decker, Sebastian Berkes, Klaus Jahn, Klaus Jahn, Max Wuehr, Max Wuehr   +7 more
doaj   +1 more source

Hubungan Antara Vertigo Dengan Riwayat Jatuh Pada Lanjut Usia Di Kota Surakarta [PDF]

, 2015
Background: Vertigo is not a disease but a symptom of a disease. Vertigo causes by the disturbance in the Vestibular system. In the elderly people’s case, the decrease of the vestibular system can cause balance disturbance. It happens because the changes
, Umi Budi Rahayu, SSt. Ft. SPd. M. Kes, , Yulisna Mutia Sari, SSt.FT., M.Sc (GRS, FAUZIAH, Enny   +2 more
core  

Downbeat nystagmus: aetiology and comorbidity in 117 patients [PDF]

, 2008
Objectives: Downbeat nystagmus (DBN) is the most common form of acquired involuntary ocular oscillation overriding fixation. According to previous studies, the cause of DBN is unsolved in up to 44% of cases.
Brandt, Thomas, Glaser, Mirjam, Strupp, Michael, Wagner, Judith N.   +3 more
core   +1 more source

Symptoms in cervical vertigo

Laryngoscope Investigative Otolaryngology, 2018
To use a unique, 41‐question survey to identify patient features distinguishing cervical vertigo from vestibular causes of vertigo and vestibular migraine.
Adam Thompson-Harvey, T. Hain
semanticscholar   +1 more source

Safety, tolerability and pharmacokinetics of DNDI‐6148, a novel agent for leishmaniasis: A randomized, controlled, single ascending dose study in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim The benzoxaborole derivative DNDI‐6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. We investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI‐6148 in a randomized, parallel‐group, placebo‐controlled ...
Jean‐Yves Gillon, Sophie Delhomme, Delphine Launay, Séverine Blesson, Stéphanie Braillard, Pegah Maghdooni, Frauke Assmus, Richard Hoglund, Joel Tarning, Sabrina Loyau, Byron Arana, Mathilde Latreille‐Barbier, Yves Donazzolo   +12 more
wiley   +1 more source

Heading direction perception in the horizontal plane is strongly driven by rotational stimuli in healthy and impaired in vestibular hypofunction

Scientific Reports
Self-motion perception relies on the central integration of vestibular, visual and proprioceptive sensory inputs into a coherent percept of self-motion. To better understand the central integration of linear and rotational stimuli, we examined rotational
Sarah Hösli, Christopher J. Bockisch, Giorgia Rita Di Ruggiero, Julia Dlugaiczyk, Dominik Straumann   +4 more
doaj   +1 more source