Results 151 to 160 of about 178,663 (403)

Safety, Pharmacokinetics, and Pharmacodynamics of Osivelotor for Sickle Cell Disease: First‐in‐Human Studies in Healthy Participants and Patients

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
The investigational agent osivelotor, a small molecule hemoglobin (Hb) modifier in development for the treatment of sickle cell disease (SCD), acts by increasing Hb‐oxygen affinity and inhibiting the polymerization of sickle Hb. We report safety, pharmacokinetic (PK), and pharmacodynamic (PD) data from the first two phase 1 clinical trials of ...
Eleanor A. Lisbon   +15 more
wiley   +1 more source

Preserving Film Preservation in the Digital Era [PDF]

open access: yes, 2013
This paper explores the current controversies surrounding film preservation in the digital era. Questions address the benefits of new technologies and the potential sacrifices to a film\u27s authenticity and designation as a valued historical, social ...
Bastron, Becca
core   +1 more source

The Differential Diagnosis of Vertigo [PDF]

open access: green, 1959
Henry L. Williams, Kendall B. Corbin
openalex   +1 more source

Itinerant curriculum theory: People's theory against the field's epistemicidal ethos

open access: yesThe Curriculum Journal, EarlyView.
Abstract The field of curriculum studies suffers from a glaring theoretical impasse. Much of this impasse has been rightly attributed to the triumphalism of the neoliberal wave that has massacred the educational hemisphere with policies and practices that reduce pedagogy to an instrumentalist praxis directly associated with the thirsty desires and ...
João M. Paraskeva
wiley   +1 more source

Clinical and neurophysiological changes in patients with pineal region expansions [Kliničke i neurofiziološke značajke u bolesnika s ekspanzivnim tvorbama pinealne regije] [PDF]

open access: yes, 2013
In the last 20 years neurological and neurosurgical follow up of our patients with pineal region expansions (118 patients) pointed to certain clinical and neurophysiological regularities.
Hajnšek, Sanja   +5 more
core  

Psychobiological Exercise Response: A Pilot Investigation of a Laboratory Exercise Assessment Paradigm Among Young Women With Eating Disorders

open access: yesInternational Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Compulsive exercise is a common feature of eating disorders (EDs) but understanding of factors that drive this symptom remains limited. This pilot trial evaluated psychobiological response to in‐laboratory exercise among females (14–22 years) with and without restrictive eating pathology.
Katherine Schaumberg   +5 more
wiley   +1 more source

Deus Ex Machina, A Concert of Electronic Compositions, May 6, 2012 [PDF]

open access: yes, 2012
This is the concert program of the Deus Ex Machina, A Concert of Electronic Compositions performance on Sunday, May 6, 2012 at 8:00 p.m., at the Marshall Room, 855 Commonwealth Avenue, Boston, Massachusetts.
School of Music, Boston University
core  

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