Results 81 to 90 of about 54,820 (261)

Effect of canalith repositioning on resting-state brain functional connectivity in patients with benign paroxysmal positional vertigo

Frontiers in Neurology
ObjectiveTo compare the characteristics of resting-state functional connectivity (FC) before and after repositioning therapy in patients with benign paroxysmal positional vertigo (BPPV) using functional near-infrared spectroscopy (fNIRS).MethodsFifty ...
Wenjia He, Xinyu Lyu, Hui Zhang, Meng Wang, Lihong Zhai, Zhanguo Jin   +5 more
doaj   +1 more source

Visual vertigo: Vertigo of oculomotor origin

Medical Hypotheses, 2018
Since Róbert Bárány proposed his hypothesis on vestibulo-ocular reflex (VOR), dizziness associated with vertigo has been interpreted as being vestibular in origin. However, there have been many contradictory findings showing modulations of VOR, which have caused confusion as to VOR's role and accuracy.
openaire   +2 more sources

Chiari I Malformation: Review and Update of Current Treatment Options

Clinical Anatomy, EarlyView.
ABSTRACT The pathophysiology of Chiari malformation type I (CM‐I) is complex, involving structural abnormalities at the craniovertebral junction that result in herniation of the cerebellar tonsils through the foramen magnum. In this study, we aim to present and evaluate current treatment options for CM‐I, with a focus on evidence‐based clinical ...
Jordan J. Lo, Shuhei Shiino, Stephen Z. Shapiro, Brianna L. Hines, Noritaka Komune, Carmine Antonio Donofrio, Filippo Badaloni, Antonio Fioravanti, Joseph Lockwood, C. J. Bui, Aaron S. Dumont, R. Shane Tubbs   +11 more
wiley   +1 more source

Clinical Whole-Body Gait Characterization Using a Single RGB-D Sensor

Sensors
Instrumented gait analysis is widely used in clinical settings for the early detection of neurological disorders, monitoring disease progression, and evaluating fall risk. However, the gold-standard marker-based 3D motion analysis is limited by high time
Lukas Boborzi, Johannes Bertram, Roman Schniepp, Julian Decker, Max Wuehr   +4 more
doaj   +1 more source

Implant‐related orofacial pain managed with implant apicoectomy: A case report

Clinical Advances in Periodontics, EarlyView.
Abstract Background In recent years, the use of implants has emerged as a widely accepted method for the replacement of missing teeth. Although rare, chronic pain associated with implant placement has been reported in the literature. Conversely, apicoectomy, the removal of the apical portion has been integrated into the implantology field in cases with
Oscar Durán‐Garnica, Karen Villarreal‐Arizpe, Hong Chen, Hsun‐Liang Chan, Guo‐Liang Cheng   +4 more
wiley   +1 more source

Pharmacokinetic Evaluation of a Cinnamon Product on CYP2A6 Substrate Drugs: Application of a Novel Tool Involving the Nicotine Metabolite Ratio

Clinical Pharmacology &Therapeutics, EarlyView.
Cinnamon (Cinnamomum spp.) is used as a culinary spice and dietary supplement. A major constituent, cinnamaldehyde, was previously shown to inactivate cytochrome P450 (CYP) 2A6 in vitro. A mechanistic static model predicted an ~5‐fold increase in the AUC of the CYP2A6 substrates nicotine and letrozole.
Aiden‐Hung P. Nguyen, Deena L. Hadi, Daniel A. Todd, Preston K. Manwill, John R. White, Matthew E. Layton, Nadja B. Cech, Kenneth E. Thummel, Mary F. Paine   +8 more
wiley   +1 more source

More Than a Question of Correlation: Characterization of the Evidentiary Basis for Biomarker Surrogates Used in European Marketing Authorizations

Clinical Pharmacology &Therapeutics, EarlyView.
Traditionally, clinical outcomes measuring how a patient feels, functions, or survives are preferred endpoints in clinical trials; however, some may take a long time to manifest in slowly developing diseases. Biomarkers, if properly validated, can serve as surrogate endpoints, acting as substitutes for clinical outcomes.
Renske Johanna Grupstra, Viktoriia Starokozhko, Elisabeth Bakker, Anna Maria Gerdina Pasmooij, Peter Gerardus Maria Mol   +4 more
wiley   +1 more source

Comprehensive exploration of unexplained dyspnoea in subjects with normal ejection fraction and low natriuretic peptides

ESC Heart Failure, Volume 12, Issue 2, Page 879-887, April 2025.
Abstract Background Unexplained exertional dyspnoea without significant elevation of natriuretic peptides is common. One of the causes might be early heart failure with preserved ejection fraction (HFpEF). Aims This study aimed to characterize patients with exertional dyspnoea and normal/near‐to‐normal N‐terminal pro‐brain natriuretic peptide (NT ...
Emmanuelle Berthelot, Tarek Laouar, Antoine Beurnier, Nataliya Hrynchynshyn, Jean Christophe Eicher, Jean‐Michel Tartière, Patrick Jourdain, Olivier Lairez, Barnabas Gellen   +8 more
wiley   +1 more source

Cilostazol in patients with heart failure and preserved ejection fraction—The CLIP‐HFpEF trial

ESC Heart Failure, Volume 12, Issue 2, Page 1437-1446, April 2025.
• Cilostazol is an oral PDE‐3 inhibitor that may have advantageous effects in heart failure with preserved ejection fraction (HFpEF). • Cilostazol significantly improved short‐term heart failure‐related health status scores (KCCQ‐12) and NT‐proBNP levels when compared to placebo.
Norman Aiad, Jeanne du Fay de Lavallaz, Michael J. Zhang, Thanat Chaikijurajai, Bo Ye, Prabhjot S. Nijjar, Julie A. Lahiri, Cindy M. Martin, Tamas Alexy, Markus Meyer   +9 more
wiley   +1 more source

Multimodal MRI of the reorganization of multisensory and sensorimotor networks in chronic bilateral vestibulopathy

NeuroImage
Chronic bilateral vestibulopathy (BVP) occurs preferably in elderly patients presenting with postural imbalance and head movement induced oscillopsia. The condition is often incomplete with residual functions in both ears. Beyond the vestibular reflexive
Marianne Dieterich, Thomas Stephan, Lena Fabritius, Rainer Boegle, Thomas Brandt   +4 more
doaj   +1 more source