Results 61 to 70 of about 322,223 (300)
Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito +14 more
wiley +1 more source
Applied Sciences, 2020 Uniaxial fatigue tests were conducted for a β titanium alloy Ti-22V-4Al up to a very high cycle fatigue (VHCF) regime. The initiation and propagation processes of the internal fatigue cracks were investigated using 3D fractographic analysis.
Gaoge Xue +4 more
doaj +1 more source
Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall +16 more
wiley +1 more source
Dissipation Assessments During Dynamic Very High Cycle Fatigue Tests [PDF]
Experimental Mechanics, 2014 This paper presents an experimental device developed to detect and estimate dissipated energy during very high cycle fatigue tests (VHCF) at high loading frequency (20 kHz) and low stress (i.e. far below the yield stress). Intrinsic dissipation is computed using local expressions of the heat diffusion equation and thermal data fields provided by an ...
Blanche, Antoine +3 more
openaire +3 more sources
Characterisation of microstructure, defect and high-cycle-fatigue behaviour in a stainless steel joint processed by brazing [PDF]
, 2019 We report the characterisation of microstructures and high-cycle-fatigue (HCF) properties of Type 304 stainless steel joints processed by brazing. Pure copper was applied as the filler metal for brazing at 1120 °C. A two-phase microstructure was obtained
Chen, B. +5 more
core +1 more source
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Testing methodologies for corrosion fatigue [PDF]
, 2015 Offshore constructions are subjected to cyclic loading conditions. This situation is combined with the corrosive nature of the surrounding environment. It is of actual concern whether the combined effect is more damaging or not than the superposition of ...
De Waele, Wim +2 more
core +1 more source
Arthritis Care &Research, EarlyView.Objective We aimed to compare clinical outcomes between patients in the Allegheny Health Network rheumatoid arthritis (RA) care pathway and patients receiving usual care. Methods The care pathway initiative implements guideline‐based best practice alongside multidisciplinary team‐based care.
Tarun Sharma +7 more
wiley +1 more source
A microplasticity evaluation method in very high cycle fatigue [PDF]
International Journal of Fatigue, 2017 Abstract This paper is concerned with an application of full-field calorimetric method for the microplasticity evaluation in the very high cycle fatigue regime. The employed method is essentially based on the establishment of an experimental energy balance during the fatigue process.
X.G. Wang, E.S. Feng, C. Jiang
openaire +1 more source
Arthritis Care &Research, EarlyView.Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo +88 more
wiley +1 more source