Results 41 to 50 of about 65,497 (208)

Adverse pregnancy outcomes of advanced maternal age pregnant women in Sri Lanka

Journal of the College of Community Physicians
Introduction: Pregnant women above 35 years are in advanced maternal age (AMA) and those above 40 years in very advanced maternal age (VAMA). These pregnancies have become common in both low- and high-income countries, including Sri Lanka, showing a ...
Poojani Illangasinghe, Palitha Karunapema, Kapila Jayaratne   +2 more
doaj   +1 more source

Impact of increased paternal age on neonatal outcomes in very-low-birth-weight infants

The Journal of Maternal-Fetal & Neonatal Medicine, 2023
Objective Despite the trend of increasing paternal age, its impact on neonatal outcomes, particularly in preterm infants, has not been thoroughly investigated.
Sol Kim, Minsoo Kim, Moon-Yeon Oh, Yumi Seo, Sook Kyung Yum   +4 more
doaj   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Perinatal outcomes in pregnancies with very and extremely advanced maternal age: An Italian multicenter retrospective cohort study

Acta Obstetricia et Gynecologica Scandinavica
Introduction Pregnancies at very and extremely advanced maternal age (VAMA, 45–49 years and EAMA, ≥50 years) are increasingly common, particularly regarding the influence of assisted reproductive technology (ART), yet their obstetric and perinatal ...
Oumaima Ammar, Maria Teresa Martini, Sara Lazzarin, Anna Luna Tramontano, Cristina Plevani, Francesca Bonati, Viola Seravalli, Fabio Facchinetti, Anna Locatelli, Sara Ornaghi, Mariarosaria Di Tommaso   +10 more
doaj   +1 more source

Characteristics of positive-interaction parenting style among primiparous teenage, optimal age, and advanced age mothers in Canada

BMC Pediatrics, 2018
Background Positive-interaction parenting early in childhood is encouraged due to its association with behavioural development later in life. The objective of this study was to examine if the level of positive-interaction parenting style differs among ...
Theresa H. M. Kim, Jennifer A. Connolly, Michael Rotondi, Hala Tamim   +3 more
doaj   +1 more source

Factors associated with the development of epilepsy in very low birth weight infants

Pediatrics and Neonatology, 2023
Background: The survival rate of very low birth weight (VLBW) infants has recently improved. However, the occurrence of and factors associated with epilepsy in VLBW infants remain unknown.
Toshimichi Fukao, Fumikazu Sano, Atsushi Nemoto, Atsushi Naito, Toshimitsu Yanagisawa, Ken Imai, Takehiko Hiroma, Yuji Inaba, Hideaki Kanemura, Masao Aihara, Takeshi Inukai, Yoshimi Kaga   +11 more
doaj   +1 more source

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

Advanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo, Caian He, Xiao Xiao, Jingmeng Li, Zilong Zhang, Ying He, Chuanchuan Wang, Jiale Zhao, Jun Gong, Jiarui Liang, Tian Yuan, Haiting Sun, Xuebo Liu, Chao Gao, Zhigang Liu   +14 more
wiley   +1 more source

Changes in maternal age and prevalence of congenital anomalies during the enactment of China's universal two-child policy (2013-2017) in Zhejiang Province, China: An observational study.

PLoS Medicine, 2020
BACKGROUND:China implemented a partial two-child policy (2013) followed by a universal two-child policy (2015), replacing the former one-child policy mandated by the government.
Xiaohui Zhang, Lijin Chen, Xuemiao Wang, Xiaoyan Wang, Menghan Jia, Saili Ni, Wei He, Shankuan Zhu   +7 more
doaj   +1 more source

Gut Microbial Release of Ferulic Acid From Germinated Quinoa Alleviates Obesity‐Associated Cognitive Impairment by Activating Hippocampal Mitophagy Associated with PINK1/Parkin Pathway

Advanced Science, EarlyView.
Liberation of ferulic acid by gut microbial feruloyl esterase mediates cognitive enhancement of germinated quinoa (GQF) on obese mice. Ferulic acid enriched in GQF is released by gut microbes Roseburia hominis and R. intestinalis and subsequently mediates the neuroprotective effects of GQF on obesity‐induced cognitive decline by activating hippocampal ...
Yongli Lan, Wengang Zhang, Lei Wang, Shiyang Zhao, Yujie Song, Xinze Wang, Yutang Wang, Xijuan Yang, Shaobo Ma, Junlin Ge, Rui Guo, Xuebo Liu   +11 more
wiley   +1 more source

Super‐Multiplexed Label‐Free Raman Imaging Uncovers Novel Testicular Metabolic Couplings for Residual Body and Spermatogonial Differentiation

Advanced Science, EarlyView.
Super‐multiplexed Label‐free Raman Imaging (SLRI) enables 2D/3D metabolic mapping of intact Drosophila testes. Moving beyond descriptive morphology, it establishes a multidimensional tool for tissue metabolic remodeling, and offers a generalizable platform for complex tissue analysis, with implications extending to development and disease. ABSTRACT The
Jiaxin Li, Xia Chen, Yujuan Qi, Chen Qiao, Qiuru Huang, Dan Zhao, Weiyi Qian, Li Di, Yi Shi, Xiangqi Hu, Yueyue Shao, Kehan Wang, Zhiyu Tang‐Yang, Hanzhi Zang, Yuwen Du, Anran Dong, Jinxiong Feng, Jiayun Chen, Ying Zheng, Xiaofang Tan, Xiaoyu Zhao, Zhonghua Shi, Bo Zheng, Jun Yu   +23 more
wiley   +1 more source