Results 101 to 110 of about 528,238 (373)

Metabolic origins and clinical significance of LDL heterogeneity

Journal of Lipid Research, 2002
LDLs in humans comprise multiple distinct subspecies that differ in their metabolic behavior and pathologic roles. Metabolic turnover studies suggest that this heterogeneity results from multiple pathways, including catabolism of different VLDL and IDL ...
Kaspar K. Berneis, Ronald M. Krauss
doaj  

Oxysterols in Vascular Cells and Role in Atherosclerosis [PDF]

Implication of Oxysterols and Phytosterols in Aging and Human Diseases, 1440, Springer International Publishing, pp.213-229, 2024, Advances in Experimental Medicine and Biology
Atherosclerosis is a major cardiovascular complication of diseases associated with elevated oxidative stress such as type 2 diabetes and metabolic syndrome. In these situations, low density lipoproteins (LDL) undergo oxidation. Oxidized LDL display proatherogenic activities through multiple and complex mechanisms which lead to dysfunctions of vascular ...
arxiv   +1 more source

Metabolism of Very-Low-Density Lipoprotein and Low-Density Lipoprotein Containing Apolipoprotein C-III and Not Other Small Apolipoproteins

Arteriosclerosis, Thrombosis and Vascular Biology, 2010
Objective—We aimed to clarify the influence of apolipoprotein C-III (apoCIII) on human apolipoprotein B metabolism. Methods and Results—We studied the kinetics of 4 very-low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), and low ...
C. Mendivil, Chunyu Zheng, J. Furtado, J. Lel, F. Sacks   +4 more
semanticscholar   +1 more source

Time‐Controlled Dual Targeting to Program Systemic and Intercellular Transfer of Therapeutic Effects

Advanced Functional Materials, EarlyView.
Aspirin‐liposomes loaded onto monocytes enable inflammation‐triggered targeting and efficient hand‐over of aspirin to inflamed cells. Monocytes uptake a significant portion of aspirin‐liposomes, prolonging therapeutic action. This approach enhances anti‐inflammatory effects through intercellular transfer, demonstrating a translational strategy for ...
Seung Eun Yu, Jueun Kim, Dae‐Hyun Kim, Sewoom Baek, Suji Park, Seyong Chung, Hak‐Joon Sung   +6 more
wiley   +1 more source

"EFFECT OF PROGESTERONE AND LOVASTATIN ON THE SECRETION OF VERY LOW DENSITY LIPOPROTEIN 1 AND 2 IN THE NORMAL GUINEA PIG MODEL" [PDF]

Acta Medica Iranica, 2004
Liver secretes a large range of very low density lipoprotein (VLDL) particles of different sizes and Svedberg flotation rates (Sf). In plasma VLDL is converted to low density lipoprotein (LDL)which in turn plays an important role in the development of ...
F. Asadi Jamnani, M. Doosti, M. Zahraei, M. Ghazi Sh. Ahmadian   +3 more
doaj   +1 more source

Apolipoprotein A-I, A-II, and VLDL-B-100 metabolism in men

Journal of Lipid Research, 2004
The impact of a low-fat diet and a high-MUFA diet on apolipoprotein A-I (apoA-I), apoA-II, and VLDL-apoB-100 metabolism in conditions of unrestricted (ad libitum) energy intake was compared in 65 men randomly assigned to one of two predefined ...
Sophie Desroches, Marie-Eve Paradis, Mélanie Pérusse, W. Roodly Archer, Jean Bergeron, Patrick Couture, Nathalie Bergeron, Benoît Lamarche   +7 more
doaj  

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray, Shehzahdi S. Moonshi, Hang Thu Ta   +2 more
wiley   +1 more source

Digitonin‐Loaded Nanoscale Metal–Organic Framework for Mitochondria‐Targeted Radiotherapy‐Radiodynamic Therapy and Disulfidptosis

Advanced Materials, EarlyView.
A mitochondria‐targeted cationic nanoscale metal organic framework shows strong radiotherapy‐radiodynamic therapy effects and selectively releases digitonin in acidic tumor microenvironments to induce disulfidptosis of cancer cells and downregulate immune checkpoints in cancer and T cells, thereby eliciting strong antitumor immunity to effectively ...
Wenyao Zhen, Yingjie Fan, Tomas Germanas, Langston Tillman, Jinhong Li, Abigail L. Blenko, Ralph R. Weichselbaum, Wenbin Lin   +7 more
wiley   +1 more source

Thematic review series: Patient-Oriented Research. What we have learned about VLDL and LDL metabolism from human kinetics studies

Journal of Lipid Research, 2006
Lipoprotein metabolism is the result of a complex network of many individual components. Abnormal lipoprotein concentrations can result from changes in the production, conversion, or catabolism of lipoprotein particles. Studies in hypolipoproteinemia and
Klaus G. Parhofer, P. Hugh R. Barrett
doaj  

A Dynamical Model of Lipoprotein Metabolism [PDF]

arXiv, 2006
We present a dynamical model of lipoprotein metabolism derived by combining a cascading process in the blood stream and cellular level regulatory dynamics. We analyse the existence and stability of equilibria and show that this low-dimensional, nonlinear model exhibits bistability between a low and a high cholesterol state.
arxiv