Results 111 to 120 of about 147,523 (312)

Studies of the Proteins in Human Plasma Very Low Density Lipoproteins

open access: hybrid, 1969
W. Virgil Brown   +2 more
openalex   +1 more source

The GRK2/AP‐1 Signaling Axis Mediates Vascular Endothelial Dysfunction and Atherosclerosis Induced by Oscillatory Low Shear Stress

open access: yesAdvanced Science, EarlyView.
This study highlights GRK2 is a central mediator in OSS‐induced endothelial dysfunction. OSS activates GPCRs in endothelial cells, leading to GRK2 phosphorylation and the activation of AP‐1. AP‐1 induces inflammation, while also promoting NR4A1 expression and anchoring LKB1 in the nucleus, which suppresses AMPK activity. This cascade causes endothelial
Li‐Da Wu   +18 more
wiley   +1 more source

Effect of Dyslipidaemia and Metabolic Function in Coronary Heart Disease with Type 2 Diabetes Mellitus - In Tertiary Care Center

open access: yesJournal of Pharmacy and Bioallied Sciences
Introduction: T2DM is strongly associated with an increased prevalence of cardiovascular disease (CVD). It has been established that CVD is the main cause of mortality among patients with type 2 diabetes mellitus (T2DM) contributing to 80% of fatal ...
Akansha Singh   +2 more
doaj   +1 more source

ATF3 Deficiency Exacerbates Ageing‐Induced Atherosclerosis and Clinical Intervention Strategy

open access: yesAdvanced Science, EarlyView.
Targeting ATF3 with terazosin to against VSMC Senescence and atherosclerosis. TZ reduces the binding affinity of YTHDF2 to Atf3 mRNA, while enhancing mRNA stability. ATF3 promotes Atg7 transcription, enhancing autophagy. ATG7 binds to ATF3 in the cytoplasm, facilitating ATF3 translocation to the nucleus and establishing positive feedback. By modulating
Hao Nie   +11 more
wiley   +1 more source

Impaired Very-Low-Density Lipoprotein catabolism links hypoglycemia to hypertriglyceridemia in Glycogen Storage Disease type Ia. [PDF]

open access: yesJ Inherit Metab Dis, 2021
Hoogerland JA   +19 more
europepmc   +1 more source

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