Results 121 to 130 of about 531,046 (373)

High‐Throughput In Vivo Screening Using Barcoded mRNA Identifies Lipid Nanoparticles With Extrahepatic Tropism for In Situ Immunoengineering

Advanced Materials, EarlyView.
A high‐throughput in vivo mRNA LNP screening platform is developed and employed to screen a large library of 122 mRNA LNPs in vivo for delivery to immune, stromal, and parenchymal cells, identifying promising LNP candidates. A novel small particle flow cytometry‐based protein adsorption analysis method is utilized to interrogate protein corona ...
Alex G. Hamilton, Ajay S. Thatte, Junchao Xu, Zhangyi Luo, Hannah C. Safford, Kelsey L. Swingle, Jenna Muscat‐Rivera, Michael Kegel, Xuexiang Han, Ryann A. Joseph, Amanda M. Murray, Hannah C. Geisler, Ricardo C. Whitaker, Lulu Xue, Roman Spektor, Jilian R. Melamed, Drew Weissman, Michael J. Mitchell   +17 more
wiley   +1 more source

Hyperlipidemia and atherosclerosis associated with liver disease in ferrochelatase-deficient mice1

Journal of Lipid Research, 2001
Erythropoietic protoporphyria (EPP) is an inherited disorder of heme synthesis caused by deficiency of the mitochondrial enzyme ferrochelatase. EPP in humans is associated with liver disease, hypertriglyceridemia, and a low level of high density ...
Vincent W. Bloks, Torsten Plösch, Harry van Goor, Han Roelofsen, Juul Baller, Rick Havinga, Henkjan J. Verkade, Aad van Tol, Peter L.M. Jansen, Folkert Kuipers   +9 more
doaj   +1 more source

Pengaruh Penggunaan Prebiotik dalam Ransum terhadap Profil Lipid Serum dan Kolesterol Daging Ayam Kampong [PDF]

, 2010
Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan prebiotik dalam ransum terhadap profil lipidserum dan kolesterol daging ayam kampong. Penelitian menggunakan rancangan acak lengkap (RAL), denganempat perlakuan (0, 10, 20 dan 30% prebiotik ...
ARIANA, I. N. (I), INDRAWATI, R. R. (R), LINDAWATI, S. A. (S), SUSILA, T. G. (T), SUTAMA, I. N. (I)   +4 more
core  

Apolipoprotein M [PDF]

, 2004
Apolipoprotein M (apoM) is a 26-kDa protein that is mainly associated with high-density lipoprotein (HDL) in human plasma, with a small proportion present in triglyceride-rich lipoproteins (TGRLP) and low-density lipoproteins (LDL).
Lund University., Luo, Guanghua, Nilsson-Ehle, Peter,, Xu, Ning,, Zhang, Xiaoying   +4 more
core   +3 more sources

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

Methylation at CPT1A locus is associated with lipoprotein subfraction profiles[S]

Journal of Lipid Research, 2014
Lipoprotein subfractions help discriminate cardiometabolic disease risk. Genetic loci validated as associating with lipoprotein measures do not account for a large proportion of the individual variation in lipoprotein measures.
Alexis C. Frazier-Wood, Stella Aslibekyan, Devin M. Absher, Paul N. Hopkins, Jin Sha, Michael Y. Tsai, Hemant K. Tiwari, Lindsay L. Waite, Degui Zhi, Donna K. Arnett   +9 more
doaj   +1 more source

Interaction between free fatty acids and insulin in the acute control of very low density lipoprotein production in humans. [PDF]

, 1995
Gary F. Lewis, Kristine D. Uffelman, Linda Szeto, Brandy Weller, George Steiner   +4 more
openalex   +1 more source

Disengaging the Engine: Histone Deacetylases 1 and 2‐Mediated Acetylation of Hexokinase‐2 Regulates Energy Metabolism in Microglia Following Intracerebral Hemorrhage

Advanced Science, EarlyView.
This study demonstrates that HDAC1/2 knockout in microglia alleviates neurological deficits, preserves white matter, and accelerates hematoma clearance after ICH. HDAC1/2 inhibition reduces HK2 acetylation, shifts metabolism from glycolysis to fatty acid oxidation, reduces inflammation, and enhances phagocytosis.
Zhiwen Jiang, Heng Yang, Xinjie Gao, Zengyu Zhang, Ruiyuan Weng, Yuchao Fei, Jiabin Su, Hanqiang Jiang, Wei Ni, Yuxiang Gu   +9 more
wiley   +1 more source

Lipolysis of very low density lipoproteins by heparan sulfate proteoglycan-bound lipoprotein lipase

Journal of Lipid Research, 1997
An in vitro assay to study lipolysis of very low density lipoproteins (VLDL) by heparan sulfate proteoglycan (HSPG-bound lipoprotein lipase (LPL) was developed.
F H de Man, F de Beer, A van der Laarse, A H Smelt, L M Havekes   +4 more
doaj   +1 more source

Low density lipoprotein receptor internalizes low density and very low density lipoproteins that are bound to heparan sulfate proteoglycans via lipoprotein lipase

Journal of Biological Chemistry, 1993
It has previously been shown that lipoprotein lipase (LPL) enhances the binding of low density lipoproteins (LDL) and very low density lipoproteins (VLDL) to HepG2 cells and fibroblasts, up to 80-fold. This increase in binding is LDL receptor-independent and is due to a bridging of LPL between extracellular heparan sulfate proteoglycans (HSPG) and the ...
Mulder, M., Lombardi, P., Jansen, H., Berkel, T.J.C. van, Frants, R.R., Havekes, L.M.   +5 more
openaire   +3 more sources