Results 141 to 150 of about 528,238 (373)

An Agrin–YAP/TAZ Rigidity Sensing Module Drives EGFR‐Addicted Lung Tumorigenesis

Advanced Science, EarlyView.
The study identifies agrin‐EGFR mechanotransduction as a critical driver of lung adenocarcinoma which enhances EGFR signaling through an integrin‐FAK‐actomyosin dependent positive feedback on YAP/TAZ ‐TEAD in response to matrix stiffness. Targeting this oncogenic loop through combinatorial treatments inhibits lung cancer due to agrin impairment.
Reza Bayat Mokhtari, Divyaleka Sampath, Paige Eversole, Melissa Ong Yu Lin, Dmitriy A. Bosykh, Gandhi T.K. Boopathy, Aravind Sivakumar, Cheng‐Chun Wang, Ramesh Kumar, Joe Yeong Poh Sheng, Ellen Karasik, Barbara A. Foster, Han Yu, Xiang Ling, Wenjie Wu, Fengzhi Li, Zoë Weaver Ohler, Christine F. Brainson, David W. Goodrich, Wanjin Hong, Sayan Chakraborty   +20 more
wiley   +1 more source

Quantitative fluorescence imaging reveals point of release for lipoproteins during LDLR-dependent uptake[S]

Journal of Lipid Research, 2013
The LDL receptor (LDLR) supports efficient uptake of both LDL and VLDL remnants by binding lipoprotein at the cell surface, internalizing lipoprotein through coated pits, and releasing lipoprotein in endocytic compartments before returning to the surface
Shanica Pompey, Zhenze Zhao, Kate Luby-Phelps, Peter Michaely   +3 more
doaj  

Pathways-driven Sparse Regression Identifies Pathways and Genes Associated with High-density Lipoprotein Cholesterol in Two Asian Cohorts [PDF]

arXiv, 2013
Standard approaches to analysing data in genome-wide association studies (GWAS) ignore any potential functional relationships between genetic markers. In contrast gene pathways analysis uses prior information on functional structure within the genome to identify pathways associated with a trait of interest. In a second step, important single nucleotide
arxiv  

Biochemical Changes in Plasma Lipids and Mineral Elements in Preeclampsia Patients in Ekiti State, Nigeria [PDF]

, 2016
This study has determined the concentrations of Total Cholesterol (TC), High Density Lipoprotein (HDL), Low  Density Lipoprotein (LDL), Triacylglyceride (TG),  Very Low Density Lipoprotein (VLDL),  Mineral Elements and some Electrolytes.
A. O, OYEYEMI, M. F, ASAOLU, O.C, OJO
core   +1 more source

 Síndrome metabólico y factores asociados en niños y adolescentes de un municipio brasileño [PDF]

, 2014
Background: the risk factors associated to metabolic syndrome (MS) have been extensively studied in adults, but in children and adolescents it is poorly explored.Objective: To identify the prevalence of MS and associated factors in children and ...
D'Almeida, Vânia, Dias Pitangueira, Jacqueline Costa, Farias Costa, Priscila Ribas de, Monteiro da Silva, Maria da Conceicao, Oliveira Assis, Ana Marlucia de, Portela de Santana, Monica Leila, Silva, Luciana Rodrigues   +6 more
core   +2 more sources

Homocysteine Promotes the Pathogenesis of Atherosclerosis through the Circ‐PIAS1‐5/miR‐219a‐2‐3p/TEAD1 Axis

Advanced Science, EarlyView.
A model is schematically represented for the major molecular mechanisms by which homocysteine (Hcy) accelerates the nuclear export of circ‐PIAS1‐5, which regulates atherosclerosis by acting as a competing endogenous RNA for miR‐219a‐2‐3p. Hcy enrichment of circ‐PIAS1‐5 leads to YTHDC1 binding to circ‐PIAS1‐5 and promotes its intracellular localization ...
Shengchao Ma, Fei Ma, Ning Ding, Lin Xie, Anning Yang, Jiangyong Shen, Yun jiao, Kai Wu, YueE Chai, Zhigang Bai, Jiantuan Xiong, Nan Li, Huiping Zhang, Yideng Jiang   +13 more
wiley   +1 more source

The roles of MMP8/MMP10 polymorphisms in ischemic stroke susceptibility

Brain and Behavior, Volume 12, Issue 12, December 2022., 2022
Abstract Background Ischemic stroke (IS), a multifactorial and polygenic disease, is the most common cause of death. This study aimed to determine the roles of MMP8/MMP10 polymorphisms in IS susceptibility in the Chinese Han population. Methods MMP8 rs1940475 and rs3765620, and MMP10 rs17860949 from 700 IS patients and 700 controls were genotyped by ...
Yong Zhao, Qi Zhang, Xiaobo Zhang, Yu Zhang, Ying Lu, Xiaojuan Ma, Weiping Li, Xiaochen Niu, Gejuan Zhang, Mingze Chang, Wenzhen Shi, Ye Tian   +11 more
wiley   +1 more source

Upregulation of hepatic VLDLR via PPARα is required for the triglyceride-lowering effect of fenofibrate

Journal of Lipid Research, 2014
The liver and the VLDL receptor (VLDLR) play major roles in TG and VLDL metabolism. However, the exact role of liver VLDLR is not well known because of the absence of or difficulty in detecting VLDLR in the liver.
Yang Gao, Wei Shen, Boyu Lu, Qingjiong Zhang, Yang Hu, Ying Chen   +5 more
doaj  

Quail eggs consumption and the levels of glucose, lipid profile in healthy students of Nnamdi Azikiwe University, Nnewi [PDF]

, 2017
Aim: The present study was design to determine serum glucose and lipid profile level of triglyceride, total cholesterol, high density cholesterol, low density lipoprotein, very low density lipoprotein following the consumption of cooked quail eggs by ...
C, Dioka Emmanuel, Chukwuemeka, Meludu Samuel, Emilia, Nwankwo, Johnkennedy, Nnodim, Pricilla, Ezeugwunne   +4 more
core   +1 more source

Very Low Density Lipoprotein Receptor (VLDLR) Expression Is a Determinant Factor in Adipose Tissue Inflammation and Adipocyte-Macrophage Interaction*

Journal of Biological Chemistry, 2013
Background: Very low density lipoprotein receptor (VLDLR) is highly expressed in adipose tissue. Results: VLDLR deficiency attenuates inflammation in adipose tissue of mice fed a high fat diet and reduces adipocyte hypertrophy and inflammation in ...
Andrew Nguyen, H. Tao, Michael D. Metrione, T. Hajri   +3 more
semanticscholar   +1 more source