JAMA cardiology, 2017 Importance In the Improved Reduction of Outcomes: Vytorin Efficacy International Trial, intensive low-density lipoprotein cholesterol (LDL-C)–reducing therapy with ezetimibe/simvastatin compared with simvastatin alone was associated with a significant ...
R. Giugliano +9 more
semanticscholar +1 more source
An integrated mathematical model of cellular cholesterol biosynthesis and lipoprotein metabolism [PDF]
, 2018 Cholesterol regulation is an important aspect of human health. In this work we bring together and extend two recent mathematical models describing cholesterol biosynthesis and lipoprotein endocytosis to create an integrated model of lipoprotein ...
Pool, Frances +2 more
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Liver international (Print), 2016 A major challenge in the management of nonalcoholic fatty liver disease (NAFLD) is to identify patients with nonalcoholic steatohepatitis (NASH) and early liver fibrosis.
Z. Jiang +12 more
semanticscholar +1 more source
High expression of antioxidant proteins in dendritic cells: possible implications in atherosclerosis [PDF]
Mol Cell Proteomics 5 (04/2006) 726-36, 2006 Dendritic cells (DCs) display the unique ability to activate naive T cells and to initiate primary T cell responses revealed in DC-T cell alloreactions. DCs frequently operate under stress conditions. Oxidative stress enhances the production of inflammatory cytokines by DCs.
arxiv +1 more source
Effect of Oral Vitamin E on Serum Lipid Profile of Apparently Healthy Nigerians in Benin City [PDF]
, 2015 Purpose: To investigate the effect of oral vitamin E on serum lipid profile of Apparently Healthy Nigerians in Benin CityMethods: Fifty eight apparently healthy non-smoking males aged 30 - 59 years were randomly selected from Benin metropolis and were ...
Adu, ME, Okosun, RE
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JAMA cardiology, 2020 Importance Low-density lipoprotein cholesterol (LDL-C), a key cardiovascular disease marker, is often estimated by the Friedewald or Martin equation, but calculating LDL-C is less accurate in patients with a low LDL-C level or hypertriglyceridemia ...
M. Sampson +14 more
semanticscholar +1 more source
A Weighted U Statistic for Genetic Association Analyses of Sequencing Data [PDF]
Genet Epidemiol. 2014 Dec;38(8):699-708, 2015 With advancements in next generation sequencing technology, a massive amount of sequencing data are generated, offering a great opportunity to comprehensively investigate the role of rare variants in the genetic etiology of complex diseases. Nevertheless, this poses a great challenge for the statistical analysis of high-dimensional sequencing data. The
arxiv +1 more source
Suppression by diets rich in fish oil of very low density lipoprotein production in man.
Journal of Clinical Investigation, 1984 The highly polyunsaturated fatty acids in fish oils lower the plasma triglyceride concentration. We have studied the effect of a diet rich in fish oil on the rate of production of the triglyceride-transporting very low density lipoprotein (VLDL).
P. J. Nestel +5 more
semanticscholar +1 more source
Moderate exercise increases affinity of large very low density lipoproteins for hydrolysis by lipoprotein lipase [PDF]
, 2015 Context: Postprandial triglyceride (TG) concentration is independently associated with cardiovascular disease risk. Exercise reduces postprandial TG concentrations but the mechanisms responsible are unclear.
Bedford, Dorothy K. +5 more
core +1 more source
Establishing reference intervals for triglyceride containing lipoprotein sub-fraction metabolites measured using Nuclear Magnetic Resonance Spectroscopy in a UK population [PDF]
, 2020 Background Nuclear magnetic resonance (NMR) spectroscopy allows triglycerides to be subclassified into 14 different classes based on particle size and lipid content.
Casas, Juan P +19 more
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