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Synthesis and function of hepatic very-low-density lipoprotein
Biochemical Society Transactions, 2004Most of the triacylglycerol (TAG) utilized for the assembly of very-low-density lipoprotein (VLDL) in the secretory apparatus of the hepatocyte is mobilized by lipolysis of the cytosolic TAG pool, followed by re-esterification. The lipases involved include arylacetamide deacetylase and/or triacylglycerol hydrolase. Some of the re-esterified products of
Anna-Marie Brown +3 more
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Proteolysis of very low density lipoprotein in perfused lung
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1978Perfusion of homologous 125I-labeled rat very low density lipoprotein through isolated rat lungs in the presence of heparin resulted in apoprotein proteolysis. At least the apoprotein C was degraded into two peptides smaller than 7500 daltons as measured by sodium dodecyl sulfate-polyacrylamide gel electrophoresis.
Julian B. Marsh +4 more
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Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1972
Abstract The catabolism of human very-low-density lipoproteins was studied by following the metabolic fate of the “minipeptides” of human very-low-density lipoproteins after the infusion of the intact human lipoprotein into squirrel monkeys (Saimira sciureus). The antigenic differences between human and monkey proteins made it possible to assay human
G. Schonfeld +3 more
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Abstract The catabolism of human very-low-density lipoproteins was studied by following the metabolic fate of the “minipeptides” of human very-low-density lipoproteins after the infusion of the intact human lipoprotein into squirrel monkeys (Saimira sciureus). The antigenic differences between human and monkey proteins made it possible to assay human
G. Schonfeld +3 more
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Kinetics of triglyceride rich lipoproteins: chylomicrons and very low density lipoproteins
Atherosclerosis, 1998Lipoprotein dynamics are complex during the postprandial state. A significant rise in chylomicron concentration is associated with increased competition for LPL with VLDL particles. This results in an increased concentration of large VLDL. The concentration of small VLDL is reduced as a result of diminished conversion of large to small VLDL.
P, Hugh, R, Barrett
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Turnover of Very Low Density Lipoprotein Proteins
1980Measurements of the rate of synthesis and removal, and of the distribution of VLDL within body pools have been derived from analysis of specific radioactivity-time curves after intravenous injections of VLDL radio-labelled in the lipid or protein moieties.
Noel Fidge, Paul J. Nestel
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Effect of desialylation of very low-density lipoproteins on their catabolism by lipoprotein lipase
Metabolism, 1985Very low-density lipoproteins (VLDL) contain sialylated apolipoproteins (apo) (eg, apo CIII1-3) that inhibit apo CII activation of lipoprotein lipase (LPL) and also uptake of triglyceride (TG)-rich lipoproteins by the liver. Hypertriglyceridemic patients can have an excess of sialylated apo CIII (apo CIII1 or apo CIII2) in VLDL. These observations have
A.M. Stoline +3 more
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Composition of very low density lipoproteins and in vitro effect of lipoprotein lipase
Clinica Chimica Acta, 1991In order to clarify the relationship between composition and lipolytic responses to lipoprotein lipase (LPL), very low density lipoproteins (VLDL) from rats or humans were incubated with a commercially available LPL or with a partially purified LPL from postheparin human plasma and fatty acids released from VLDL were determined in vitro. VLDL from rats
Kiyohisa Uchida +4 more
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Inhibition of lipoprotein lipase by an apoprotein of human very low density lipoprotein
Biochemical and Biophysical Research Communications, 1972Summary The effects of two apolipoproteins isolated from human very low density lipoproteins (apoLp-Glu and apoLp-Ala) on lipoprotein lipase (LPL) activity have been studied. ApoLp-Glu markedly stimulated LPL as reported by others. ApoLp-Ala isolated by techniques previously described also activated LPL at low levels.
M.L. Baginsky, W. Virgil Brown
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Comparative proteomic profiling of plasma very-low-density and low-density lipoproteins
Clinica Chimica Acta, 2010Low-density lipoprotein (LDL) is a natural metabolite of very-low-density lipoprotein (VLDL) in the circulation. Systematic investigation of total protein components and dynamics might provide insights into this normal metabolic process.VLDL and LDL were purified from normolipidemia pooled plasma by gradient ultracentrifugation with either ionic or non-
Hung Yu Sun +7 more
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Very low density lipoprotein metabolism in diabetes mellitus
Diabetes/Metabolism Reviews, 1987The concentration of VLDL and their major lipid, triglyceride, are regulated at many levels from the initial availability of the substrates needed for their synthesis all the way to the function of the enzymes and receptors involved in their removal from plasma.
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