Results 71 to 80 of about 888,948 (354)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

White matter volume and anisotropy in very low birth weight preterm born children: association with cognitive outcome [PDF]

, 2006
INTRODUCTION: Low birth weight premature infants are at risk of brain injury, especially to the white matter. These complications result from either the inability to repair the lesions acquired around birth, or disruption of the normal maturation process.
Chua, SE, Khong, PL, Lam, BCC, Leung, C, McAlonan, GM, Poon, GWK, Qiu, D, Yung, AWY   +7 more
core  

Vitamin A Supplementation in Preterm Very Low Birth Weight Neonates [PDF]

Indian Journal of Neonatal Medicine and Research, 2015
Vitamin A is involved in regulation of fetal lung growth. It protects the preterm lung from oxidative damage. It maintains the integrity of respiratory tract epithelium and helps in differentiation of epithelial cells.
Kamaldeep Arora, Anu Thukral, Rashmi Ranjan Das   +2 more
doaj   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Developmental outcome of very low birth weight infants in a developing country [PDF]

, 2012
BACKGROUND: Advances in neonatal care allow survival of extremely premature infants, who are at risk of handicap. Neurodevelopmental follow up of these infants is an essential part of ongoing evaluation of neonatal care.
Daynia E Ballot, Joanne Potterton, Nicole Hilburn, Peter A Cooper, Tobias Chirwa   +4 more
core   +2 more sources

Paternal race/ethnicity and very low birth weight [PDF]

BMC Pregnancy and Childbirth, 2014
The purpose was to examine the association between paternal race/ethnicity and very low birth weight stratified by maternal race/ethnicity.Birth data for Tarrant County, Texas 2006-2010 were analyzed. Very low birth weight was dichotomized as yes (
Elizabeth Balyakina, Anita K. Kurian, Micky M Moerbe, Kimberly G. Fulda   +3 more
openaire   +3 more sources

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Decline in the negative association between low birth weight and cognitive ability [PDF]

, 2016
Low birth weight predicts compromised cognitive ability. We used data from the 1958 National Child Development Study (NCDS), the 1970 British Cohort Study (BCS), and the 2000–2002 Millennium Cohort Study (MCS) to analyze how this association has changed ...
Goisis, Alice, Myrskylä, Mikko, Özcan, Berkay   +2 more
core   +1 more source

Growth monitoring of very low-birth weight infants

Current Medicine Research and Practice, 2012
Very low-birth weight (VLBW) infants suffer significant perinatal and neonatal morbidity. The survival of VLBW infants has improved over the past few decades.
Manoj Modi
doaj  

BCS1L‐Associated Disease: 5′‐UTR Variant Shifts the Phenotype Towards Axonal Neuropathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To investigate the consequences of a pathogenic missense variant (c.838C>T; p.L280F) and a 5′‐UTR regulatory variant (c.‐122G>T) in BCS1L on disease pathogenesis and to understand how regulatory variants influence disease severity and clinical presentation.
Rotem Orbach, Nunziata Maio, Russell J. Butterfield, A. Reghan Foley, Sarah Silverstein, Yan Li, Katherine Chao, Tanya J. Lehky, Abigail Potticary, Tracey A. Rouault, Sandra Donkervoort, Carsten G. Bönnemann   +11 more
wiley   +1 more source