Results 101 to 110 of about 92,005 (265)

Maternal‐Fetal Administration of Risdiplam Partially Rescues the SMNΔ7 Mouse Model of Spinal Muscular Atrophy

open access: yesAnnals of Neurology, EarlyView.
Objective Spinal muscular atrophy (SMA) is caused by deletions or mutations in the survival motor neuron 1 (SMN1) gene and subsequent reduction in the expression of survival motor neuron (SMN) protein. The disease is characterized by degeneration of α motor neurons and subsequent muscle atrophy.
Emma R. Sutton   +4 more
wiley   +1 more source

Late‐Stage Functionalization of Peptides on the Solid Phase

open access: yesAngewandte Chemie International Edition, EarlyView.
Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner   +2 more
wiley   +1 more source

The morphology of the oval window in Paranthropus robustus compared to humans and other modern primates

open access: yesThe Anatomical Record, EarlyView.
Abstract The oval window (OW) is an opening connecting the inner and middle ear. Its area has been shown to consistently scale with body mass (BM) in primates, and has been used alongside semi‐circular canal (SCC) size to differentiate Homo sapiens and fossil hominins, including Paranthropus robustus.
Ruy Fernandez, José Braga
wiley   +1 more source

An unusual titanosaur axis from the Upper Cretaceous of Brazil and its significance for sauropod anatomy and systematics

open access: yesThe Anatomical Record, EarlyView.
Abstract The Upper Cretaceous São José do Rio Preto Formation (Bauru Group, southeastern Brazil) has yielded a fragmentary but taxonomically diverse record of titanosaur sauropods, although elements from cervical series remain scarce. Here, we describe a nearly complete sauropod axis from the Vila Ventura Paleontological Area, representing an uncommon ...
Bruno A. Navarro   +7 more
wiley   +1 more source

A critical reappraisal of the carotid sinus and carotid bulb: Distinguishing neurohistological function from vascular geometry

open access: yesThe Anatomical Record, EarlyView.
This review redefines the carotid bulb (CB) as a variable geometric dilation shaped by hemodynamics and the carotid sinus (CS) as a conserved neurohistological baroreceptor field. Distinguishing these entities clarifies a century of anatomical confusion and links geometry, neurohistology, and clinical interpretation within a unified framework ...
Răzvan Costin Tudose   +2 more
wiley   +1 more source

Over the edge: Empirical evidence for the cliff‐edge model of obstetric selection

open access: yesThe Anatomical Record, EarlyView.
Abstract The cliff‐edge model of obstetric selection maintains that larger neonates and smaller birth canals confer a positive selective advantage until labor becomes obstructed and vaginal delivery is no longer possible, eliciting an abrupt reduction in fitness.
Laura M. Watson   +6 more
wiley   +1 more source

Pelvic morphology and body size in relation to the preauricular sulcus: Evidence from medieval to modern Iberia

open access: yesThe Anatomical Record, EarlyView.
Abstract The preauricular sulcus has long been debated as a pelvic feature variably attributed to obstetric stress, ligamentous traction, and broader biomechanical processes. To clarify its determinants, we analyzed 409 adult individuals from three archeological and one early modern skeletal collection from the Iberian Peninsula, integrating graded ...
Rebeca García‐González   +5 more
wiley   +1 more source

Tracing the evolutionary history of the morpho‐anatomy of baculum in primates

open access: yesThe Anatomical Record, EarlyView.
Abstract Animal morphology reflects both evolutionary history and present‐day adaptation. Male mammal copulatory structures such as the baculum (penile bone) are ideal for studying these processes because of their complexity and high interspecific variability. In primates, however, research has focused mostly on baculum length.
Federica Spani   +3 more
wiley   +1 more source

Different shape but the same topographical complexity—The lingual gross anatomy of the Saimaa (Pusa saimensis) and Baltic ringed seals (Pusa hispida botnica)

open access: yesThe Anatomical Record, EarlyView.
Abstract Despite the distinctly different shapes of their tongues, the tongue gross anatomy of Saimaa ringed seal closely resembled that of Baltic ringed seal. There were no differences in the extrinsic and intrinsic tongue muscles or their associated vascularization and innervation between Saimaa and Baltic ringed seals.
Juha Laakkonen, Heini Nihtilä
wiley   +1 more source

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