Results 121 to 130 of about 3,008,306 (295)

Development of retinal blood vessel segmentation methodology using wavelet transforms for assessment of diabetic retinopathy [PDF]

, 2005
Automated image processing has the potential to assist in the early detection of diabetes, by detecting changes in blood vessel diameter and patterns in the retina.
Mitchell, P., Jelinek, Herbert J., Cesar, R.M., Jr., Cornforth, D.J., Bossomaier, T., Leandro, J.J.G., Soares, J.V.B., Cree, Michael J.   +7 more
core  

Retinal Vessel Density and Retinal Nerve Fiber Layer Thickness: A Prospective Study of One-Year Follow-Up of Patients with Parkinson’s Disease

, 2023
Min Tu,1,2,* Shuangfeng Yang,3,* Lan Zeng,2 Yuling Tan,2 Xiaoming Wang2 1People’s Hospital of Deyang City, Department of Neurology, Deyang, People’s Republic of China; 2Affiliated Hospital of North Sichuan Medical College, Department of Neurology,
Zeng L, Tan Y, Tu M, Wang X, Yang S
core  

Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development

Advanced Healthcare Materials, EarlyView.
LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans, Abdulwahhab Khedr, Panagiotis G. Georgiou, Nehir Arik, Ozlem Sen, Steve P. Rannard, Tom O. McDonald, Christos Tapeinos   +7 more
wiley   +1 more source

OCT Angiography–Based Quantitative Choroidal Vasculature Analysis in Choroidal Melanomas and Nevi

Ophthalmology Science
Purpose: Differentiation between choroidal melanoma (CM) and choroidal nevus (CN) is primarily made clinically with the aid of multimodal imaging. Both entities can be distinguished by their vascular architecture in histopathology. OCT angiography (OCT-A)
Tekla Kurdiani, Miltiadis Fiorentzis, MD, Nikolaos E. Bechrakis, MD, Tobias Kiefer, MD   +3 more
doaj   +1 more source

Clinical factors associated with trabecular bone score.

, 2013
Dual-energy X-ray absorptiometry (DXA) measurement of bone mineral density (BMD) is the reference standard for diagnosing osteoporosis but does not directly reflect deterioration in bone microarchitecture.
Hans, D., Leslie, W.D., Manitoba Bone Density, Program, Krieg, M.A.   +3 more
core   +1 more source

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source

Photovoltaic Stimulation of Mouse and Pig Retina With Pyrolytic Carbon Microelectrodes Integrated on High‐Density Silicon Solar Cell Arrays

Advanced Healthcare Materials, EarlyView.
In this study, we fabricate photovoltaic retinal implants with pyrolytic carbon electrodes and test their ability to stimulate mouse and pig retinas when illuminated with near‐infrared light. We find increased spiking activity in both animal models compared to spontaneous activity and TTX controls and analyze the spike amplitude, latency and frequency.
Akihiro Matsumoto, Pratik Kusumanchi, Jesper Guldsmed Madsen, Asbjørn Cortnum Jørgensen, Gisele Alves dos Reis Benatto, Sune Thorsteinsson, Peter Behrensdorff Poulsen, Keisuke Yonehara, Toke Bek, Stephan Sylvest Keller, Rasmus Schmidt Davidsen   +10 more
wiley   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Magnetically Driven Biofabrication for Tissue Engineering: From Nanoparticle Design to Mag‐ATMP Translation

Advanced Healthcare Materials, EarlyView.
Magnetically responsive nanoparticles enable remote control over biomaterials, cells, and engineered tissues. This review summarizes material design, biological safety, fabrication and actuation strategies, computational validation, and translational pathways that support the development of magnetic tissue‐engineering platforms and future magnetically ...
Konstantinos Ioannidis, Dimitrios Lefas, Maya Guilliams, Jackie Van Grootenbril, Isaak Decoene, Dimitrios Sakellariou, Bart Smeets, Stefanos Mourdikoudis, Ioannis Papantoniou   +8 more
wiley   +1 more source

Diagnostic abilities of vessel density and structural measurements.

, 2017
Sensitivity at 95% specificity of (a) optic nerve head vessel density and rim area, (b) peripapillary vessel density and retinal nerve fiber layer (RNFL) thickness and (c) superficial macular vessel density and ganglion cell complex (GCC) thickness ...
Narendra K. Puttaiah (3833503), Robert N. Weinreb (170002), Srilakshmi Dasari (3833488), Dhanaraj A. S. Rao (3833491), Carroll A. B. Webers (3833485), Mohammed Riyazuddin (3833506), Sathi Devi (3833497), Kaweh Mansouri (734957), Harsha L. Rao (639504), Zia S. Pradhan (3833500), Jayasree P. Venugopal (3833494)   +10 more
core   +1 more source