Results 41 to 50 of about 4,957,847 (265)

Unraveling Bone‐Skin Crosstalk Enables miRNA Nanoformulation for Cutaneous Neurovascular Reconstruction in Diabetic Mice

Advanced Science, EarlyView.
This study unravels that bone fracture accelerates diabetic wound healing by releasing exosomal microRNA (miR‐130b‐3p). To mimic this bone‐skin crosstalk, we engineered a self‐assembling agomir‐130b‐3p nanocomplex. Delivered via a photocrosslinkable hydrogel, this bio‐inspired therapy provides sustained localized agomir release.
Tao Shen, Hongdou Shen, Weiyue Wu, Zhuoying Jiang, Bin Liu, Yansi Xian, Rui Peng, An Yan, Yu Ben, Yong Shi, Xiang Chen, Baosheng Guo, Qing Jiang, Weijun Wang, Pingqiang Cai   +14 more
wiley   +1 more source

Decentralized Documentation of Maritime Traffic Incidents to Support Conflict Resolution

Journal of Marine Science and Engineering, 2022
For the investigation of major traffic accidents, larger vessels are obliged to install a voyage data recorder (VDR). However, not every vessel is equipped with a VDR, and the readout is often a manual process that is costly.
Dennis Jankowski, Julius Möller, Hilko Wiards, Axel Hahn   +3 more
doaj   +1 more source

[Tools] Marine Traffic

, 2023
Marine Traffic gathers data from more than 18,000 AIS equipped volunteer contributors in over 140 countries around the world. Information provided by the volunteer AIS equipment includes vessel unique identification, position, course, and speed.
Marine Traffic
core  

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Traffic Demand Forecasting for Port Services [PDF]

, 2011
Successful management of any sea port depends primarily on the harmonisation of transport supply and demand, whereas their incompatibility leads to a number of problems. The port, i.e.
Poletan Jugović, Tanja, Alen Jugović, Tanja Poletan Jugović, Hess, Svjetlana, Jugović, Alen, Svjetlana Hess   +5 more
core   +1 more source

Dual Lineages of Langerhans Cells Cooperate to Restore the Immune Barrier after Skin Injury

Advanced Science, EarlyView.
After skin injury, the epidermal immune barrier is rebuilt by two sources of Langerhans cells. Resident Langerhans cells first move into the wound during re‐epithelialization, guided by CXCR2 signaling. Later, recruited monocytes become long‐lived Langerhans cells.
Axel D. Schmitter‐Sánchez, Nicholas Basista, Sudhanshu Mishra, Hyeri Kim, Audrey Bench, Catherine Matte‐Martone, Min‐Soo Seo, Gun Woo Lee, Sangbum Park   +8 more
wiley   +1 more source

Navigating the Future: Developing Smart Fairways for Enhanced Maritime Safety and Efficiency

Journal of Marine Science and Engineering
The maritime industry is rapidly evolving with digital technologies, aiming to enhance efficiency, safety, and sustainability. Recent interest has focused on autonomous vessels and the digitalization of ports, yet fairway development has lagged behind ...
Marikka Heikkilä, Heidi Himmanen, Olli Soininen, Sanna Sonninen, Jukka Heikkilä   +4 more
doaj   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Dual‐Organelle Secretome Conjugation and Organ‐Uptake Tracking (DuO‐SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins

Advanced Science, EarlyView.
A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...
Fenglian Yang, Rui Qian, Jiaxing Song, Xingqi Meng, Jin Young Kim, Kwok On Lai, Li Wang, Liang Zhang   +7 more
wiley   +1 more source

Vessel Traffic in the Strait of Istanbul

, 2009
This study develops a high-fidelity simulation model for the vessel traffic in the Strait of Istanbul using the Arena simulation tool. The simulation model is developed mainly for risk analysis and mitigation purposes.
Or, I., Almaz, A. Oe, Altiok, T., Oezbas, B., Uluscu, Oe. S.   +4 more
core   +1 more source