Results 51 to 60 of about 10,734,099 (257)

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Estimating the causal effect of frailty index on vestibular disorders: A two-sample Mendelian randomization

Frontiers in Neuroscience, 2022
BackgroundFrailty index and vestibular disorders appear to be associated in observational studies, but causality of the association remains unclear.MethodsA two-sample Mendelian randomization (MR) study was implemented to explore the causal relationship ...
Gui Xiao, Gui Xiao, Hu Wang, Jiaji Hu, Li Liu, Li Liu, Tingting Zhang, Tingting Zhang, Mengjia Zhou, Mengjia Zhou, Xingxing Li, Xingxing Li, Chunxiang Qin, Chunxiang Qin   +13 more
doaj   +1 more source

Cross-modal sensory signaling shapes vestibulo-motor circuit specificity [PDF]

, 2015
The ability to continuously adjust posture and balance is necessary for reliable motor behavior. Vestibular and proprioceptive systems influence postural adjustments during movement by signaling functionally complementary sensory information. Using
Basaldella, Emanuela
core   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

Combined presigmoid retrolabyrinthine and retrosigmoid approach for large vestibular schwannoma: a case report

Frontiers in Surgery
BackgroundThe retrosigmoid approach is widely used for vestibular schwannoma resection. If the tumor is large, significant cerebellar retraction may be required, which can cause cerebellar edema.
Mitsuru Kojima, Ryota Tamura, Konosuke Ishikawa, Taichi Sayanagi, Kosuke Karatsu, Ryo Ueda, Masahiro Toda   +6 more
doaj   +1 more source

Effect of Vestibular Rehabilitation and Gaze Stabilisation Exercises in individuals with Motion Sickness: A Case Report [PDF]

Journal of Clinical and Diagnostic Research
Motion sickness is a vestibular disorder resulting from sensory conflict between visual, vestibular, and somatosensory inputs, leading to symptoms such as nausea, dizziness, sweating and postural instability.
Isha Goel, Subhasish Chatterjee, Mousumi Saha, Mritunjay Kumar, Kashish Maggu   +4 more
doaj   +1 more source

The intrinsic plasticity of medial vestibular nucleus neurons during vestibular compensation—a systematic review and meta-analysis

Systematic Reviews, 2020
Background Vestibular compensation is a homeostatic process that occurs in the central nervous system in response to peripheral vestibular dysfunction. Experimental studies in rodent models have suggested that unilateral peripheral vestibular lesions are
Rajiv Wijesinghe, Aaron Camp
doaj   +1 more source

A durable gain in motor and non-motor symptoms of Parkinson’s Disease following repeated caloric vestibular stimulation: A single-case study [PDF]

, 2016
Objective: To gain ‘first-in-man’ evidence that repeated caloric vestibular stimulation (CVS), a non-invasive form of neuro-modulation, can induce a lasting and clinically-relevant reduction in Parkinson’s Disease (PD) symptoms.
Podlewska, Aleksandra, Sakel, Mohamed, Wilkinson, David T.   +2 more
core   +1 more source

Retrospective Grid Cells in the Medial Entorhinal Cortex Encode Past Paths During Spatial Navigation

Advanced Science, EarlyView.
Retrospective grid cells are identified in the medial entorhinal cortex, with spatial firing patterns that become most grid‐like when activity is projected onto recently traversed locations. Their coding loses spatial precision in darkness and is disrupted during assisted movement, indicating that entorhinal representations incorporate recent path ...
Ruojin Liu, Xin Yuan, Zilong He, Hong Jin, Jiayi Tian, Cong Chen, Yuanjing Liu, Xiang Zhang, Shidan Wen, Emilio Kropff, Chenglin Miao   +10 more
wiley   +1 more source

The effect of repeated sessions of galvanic vestibular stimulation on target cancellation in visuo-spatial neglect: Preliminary evidence from two cases [PDF]

, 2013
Objective: In recent years it has emerged that the attentional disorder of visuo-spatial neglect can be overcome via artificial stimulation of the balance system.
Sakel, Mohamed, Langston, Deborah, Wilkinson, David T., Zubko, Olga   +3 more
core   +1 more source