Results 51 to 60 of about 2,200,753 (298)

Engineering Pluripotent Stem Cells‐Derived Inner Ear Organoids With Enhanced Maturation and Reproducibility by Micro‐Topographical Cues

Advanced Materials, EarlyView.
Micro‐topographical cues applied through temporally controlled microscale confinement improve the reproducibility, spatial organization, and neurosensory‐associated features of pluripotent stem cell‐derived inner ear organoids. Integration with a vascularized organoid platform further enables controlled investigation of vascular‐epithelial interactions
Harshita Sharma, Jungeun Lim, Woochan Kim, Yeon Ju Kim, Dream Kim, Shinyull Lee, Chaeyeon Park, Stephen Rhee, Shruthy Kuttapan, Jungho Ha, Sang Wook Park, Kyunghoon Kim, Noo Li Jeon, Sunho Park, Yun‐Hoon Choung, Jangho Kim   +15 more
wiley   +1 more source

A newmethod to analyze the subjective visual vertical in patients with bilateral vestibular dysfunction

Clinics, 2012
OBJECTIVE: The aim of this study was to assess the subjective visual vertical in patients with bilateral vestibular dysfunction and to propose a new method to analyze subjective visual vertical data in these patients.
Martha Funabashi, Taiza Elaine Grespan Santos-Pontelli, José Fernando Colafêmina, Theo Zeferino Pavan, Antonio Adilton Oliveira Carneiro, Osvaldo Massaiti Takayanagui   +5 more
doaj   +1 more source

Comparison of Clinical Balance and Visual Dependence Tests in Patients With Chronic Dizziness With and Without Persistent Postural-Perceptual Dizziness: A Cross-Sectional Study

Frontiers in Neurology, 2022
BackgroundThe diagnosis of persistent postural-perceptual dizziness (PPPD) is primarily based on medical history taking. Research on the value of clinical balance and visual dependence tests in identifying PPPD is scarce.Objectives(1) to contrast ...
Charlotte De Vestel, Charlotte De Vestel, Willem De Hertogh, Willem De Hertogh, Vincent Van Rompaey, Vincent Van Rompaey, Luc Vereeck, Luc Vereeck   +7 more
doaj   +1 more source

Unveiling Otolith Mystery: Contemporary Testing Approaches and Their Clinical Significance. [PDF]

World J Otorhinolaryngol Head Neck Surg
ABSTRACT Objective Otolith is a critical component of the peripheral vestibular system responsible for detecting linear acceleration. Dysfunction of the otolith organs can lead to vertigo, balance disturbances, and gaze instability. By elucidating the physiological foundations and evaluating both current and emerging methods for assessing otolith ...
Zhou S, Tian E, Yang HJ, Wang J, Guo ZQ, Chen JY, Xu WD, Guo JQ, Zhou ZH, Shi SY, Yu XX, Gao XB, Zhai N, Ma X, Zhang Q, Lu YS, Zhang SL.   +16 more
europepmc   +2 more sources

Integration of vestibular and proprioceptive signals for spatial updating [PDF]

, 2011
Frissen I, Campos JL, Souman JL, Ernst MO. Integration of vestibular and proprioceptive signals for spatial updating. Experimental Brain Research. 2011;212(2):163-176.Spatial updating during self-motion typically involves the appropriate integration of ...
Ernst, MO, Marc O. Ernst, Frissen, I., Souman, JL, Campos, JL, Souman, J., Campos, J., Ernst, M., Jan L. Souman, Jennifer L. Campos, Frissen, I, Ilja Frissen, Ernst, Marc O.   +12 more
core   +1 more source

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

A durable gain in motor and non-motor symptoms of Parkinson’s Disease following repeated caloric vestibular stimulation: A single-case study [PDF]

, 2016
Objective: To gain ‘first-in-man’ evidence that repeated caloric vestibular stimulation (CVS), a non-invasive form of neuro-modulation, can induce a lasting and clinically-relevant reduction in Parkinson’s Disease (PD) symptoms.
Podlewska, Aleksandra, Sakel, Mohamed, Wilkinson, David T.   +2 more
core   +1 more source

Sense of direction in vestibular disorders

, 2023
BACKGROUND: Our sense of direction (SOD) ability relies on the sensory integration of both visual information and self-motion cues from the proprioceptive and vestibular systems.
Moore, Alexander IG, Golding, John F, Bronstein, Adolfo M, Castro, Patricia, Alenova, Anastasia   +4 more
core   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Vertiginous Symptoms and Objective Measures of Postural Balance in Elderly People with Benign Paroxysmal Positional Vertigo Submitted to the Epley Maneuver

International Archives of Otorhinolaryngology, 2016
Introduction Benign Paroxysmal Positional Vertigo (BPPV) is one of the most common and treatable causes of peripheral vestibular vertigo in adults. Its incidence increases with age, eventually leading to disability and a decreased quality of life.
Camila Nicácio da Silva, Karyna Myrelly O. B. de Figueiredo Ribeiro, Raysa Vanessa de Medeiros Freitas, Lidiane Maria de Britho Macedo Ferreira, Ricardo Oliveira Guerra   +4 more
doaj   +1 more source