Results 131 to 140 of about 168,687 (350)

Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors

Advanced Science, EarlyView.
This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy, Angela Martin‐Regalado, Benedikt E. Haupt, Jacob R. Pogue, Aditi Thakur, Manuel Fierro Cota, Markella Zannikou, Sol Misener, Vera P. Krymskaya, Kathleen McCortney, Jason Miska, Craig Horbinski, Dmitri Simberg, Maciej S. Lesniak, Charles D. James, Roger Stupp, Irina V. Balyasnikova   +16 more
wiley   +1 more source

Tailored biosecurity training for veterinarians and farmers: bridging knowledge and practice gaps

Frontiers in Veterinary Science
Biosecurity is fundamental to animal health, public health, and the economic resilience of livestock systems; however, farm-level adoption remains uneven across regions.
Blerta Mehmedi, Jarkko Niemi, Claude Saegerman, Daniele De Meneghi, Anna Maria Iatrou, Ramazan Yildiz, Ilias Chantziaras, Alberto Allepuz, Ina Toppari, Georgios Batikas, Arvo Viltrop, Tarmo Niine   +11 more
doaj   +1 more source

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

JOB SATISFACTION AND STRESS AMONG THE VETERINARIANS OF KERALA STATE IN INDIA [PDF]

Journal of Veterinary and Animal Sciences, 2013
A study was undertaken to know the important aspects of job situation in terms of stress factors which influence job satisfaction. The two top ranking stress factors found were prescribing costly medicines to poor livestock owner and large animal ...
Soumya Sankar, P. Reeja George, P.J. Raj Kamal   +2 more
doaj  

Methylglyoxal Accumulation is Associated with Brain Inflammation after Myocardial Infarction with Sex and Regional Differences

Advanced Science, EarlyView.
This study identifies that methylglyoxal may play an important role in heart‐brain interactions after myocardial infarction. Myocardial infarction leads to increased levels of methylglyoxal‐derived advanced glycation end‐products (MG‐H1) in the brain of mice, which is associated with loss of blood‐brain barrier integrity and neuroinflammation ...
Ramis Ileri, Xixi Guo, Erik J. Suuronen
wiley   +1 more source

Animal Industry News, April 2006, Vol. 7, no. 1 [PDF]

, 2006
Newsletter produced by Department of Agriculture and Land Stewardship about the animal industry in ...

core  

The Trichinella Super‐Pangenome Reveals the Evolution of Encapsulation and Predicted Host–Parasite Protein Interactions

Advanced Science, EarlyView.
ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv, Yi Liu, Ning Xu, Xiao Zhang, Yaming Yang, Chengyao Li, Hanhai Mao, Mingyuan Liu, Xiaolei Liu   +8 more
wiley   +1 more source

Validation of the burnout assessment tool-core symptoms in Spanish veterinarians, sex invariance, and cutoff points

Frontiers in Veterinary Science
Notably, most studies on burnout in Veterinary Medicine have used the Maslach Burnout Inventory; however, it has limitations and does not evaluate severe burnout. Therefore, in this study, we validated the Burnout Assessment Tool-Core Symptoms (BAT-C) in
Amparo Osca, Jesús Barrado, Lorena Millán   +2 more
doaj   +1 more source

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, EarlyView.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source

Veterinarians’ Perspectives on the Antimicrobial Resistance (AMR) Dashboard: A Survey of Needs and Preferences to Inform Development

Veterinary Sciences
Antimicrobial resistance (AMR) poses a significant global threat to human and animal health, necessitating robust surveillance and stewardship tools. While existing systems address aspects of veterinary AMR, a comprehensive, user-centric dashboard for U ...
Abraham Joseph Pellissery, Thomas Denagamage, Maura Pedersen, Subhashinie Kariyawasam   +3 more
doaj   +1 more source