Results 141 to 150 of about 2,887,793 (388)

A Human Engineered Heart Tissue‐Derived Lipotoxic Diabetic Cardiomyopathy Model Revealed Early Benefits of Empagliflozin

open access: yesAdvanced Science, EarlyView.
This study develops a human engineered heart tissue‐derived model of diabetic cardiomyopathy that accurately replicates the dynamic changes in the structural, contractile, and electrophysiological properties of the myocardium. Furthermore, this model is used to confirm the direct protective effects of empagliflozin on the heart through an SGLT2 off ...
Lin Cai   +9 more
wiley   +1 more source

Structural Variations Associated with Adaptation and Coat Color in Qinghai‐Tibetan Plateau Cattle

open access: yesAdvanced Science, EarlyView.
This study reveals the landscape of structural variants in Qinghai‐Tibetan Plateau cattle through long‐read sequencing. Discoveries include metabolic and oxygen‐regulation gene variants, along with a 2‐Mb KIT‐containing inversion and translocations responsible for cattle gray coat. These findings highlight the significant role of structural variants in
Xiaoting Xia   +39 more
wiley   +1 more source

Perspectives in Veterinary Medicine: Prologue [PDF]

open access: yes, 2013
Perspectives in Veterinary Medicine was initiated during the 150th Anniversary year of the American Veterinary Medical Association founded in 1863.
Smith, Donald F.
core  

Lipid Droplet‐Organized MDM2‐Mediated P53 Degradation: A Metabolic Switch Governing Diet‐Driven Tumor Progression

open access: yesAdvanced Science, EarlyView.
Tumor‐associated TP53 inactivation correlates with lipid droplet (LD) accumulation. High‐fat diets drive Cyb5r3‐Myh9‐mediated p53 enrichment on LD surfaces, accelerating its degradation while upregulating LD‐promoting factor CD36 expression to establish a feed‐forward loop. LD suppression or dietary intervention restores p53 and inhibits tumorigenesis,
Haiyang Liu   +20 more
wiley   +1 more source

The veterinary profession and one medicine: some considerations, with particular reference to Italy [PDF]

open access: yesVeterinaria Italiana, 2011
The concept of ‘one medicine’ and its evolution are discussed and some considerations on the relationship between ‘one medicine’ and veterinary profession are made, with particular reference to Italy.
Giorgio Battelli, Adriano Mantovani
doaj  

Pre-Veterinary Newsletter, February 2006 [PDF]

open access: yes, 2006
Topics in this issue include: Class of 2010; Upcoming Presentations; College of Veterinary Medicine Open House; Association of American Veterinary Medical Colleges Hosts High School / College of Veterinary Medicine Fair in Washington DC; Expanding ...
Cornell University. College of Veterinary Medicine. DVM Admissions.   +1 more
core  

Delayed Transplantation of Neural Stem Cells Improves Initial Graft Survival after Stroke

open access: yesAdvanced Science, EarlyView.
Delayed transplantation of human iPSC‐derived neural progenitor cells (NPCs) enhances graft survival, proliferation, and axonal sprouting after stroke. Using bioluminescence imaging and histology in a mouse model of stroke, it is shown that NPC delivery at 7 days post‐stroke is more effective than acute transplantation, highlighting the importance of ...
Rebecca Z Weber   +6 more
wiley   +1 more source

The Institute Report from the Cornell Research Laboratory for Diseases of Dogs [PDF]

open access: yes, 1972
Topics in this Institute Report include: Message from the Director [James A. Baker]: The Research Program, Education, Financial Situation; Virus Research Institute Staff: Administration, Animal Care, Maintenance, Laboratories, Cooperating Staff ...
Baker, James A.   +1 more
core   +1 more source

GHSR‐Foxo1 Signaling in Macrophages Promotes Liver Fibrosis via Inflammatory Response and Hepatic Stellate Cell Activation

open access: yesAdvanced Science, EarlyView.
Macrophage GHSR‐Foxo1 axis regulates CCl4‐induced liver fibrosis by promoting inflammation and TGF‐β1‐mediated HSC activation. GHSR activates PKA‐dependent phosphorylation of Foxo1 at serine 273, promoting macrophage pro‐inflammatory polarization to enhance the production of pro‐inflammatory cytokines that damage hepatocytes, thereby inducing liver ...
Da Mi Kim   +9 more
wiley   +1 more source

Home - About - Disclaimer - Privacy