Are Intellectual Property Rights Detrimental to Innovation? [PDF]
Intellectual property rights are legal constraints that limit entry in industries where incumbents are innovators. The set of legal constraints is the same for all industries, without considering that the externalities created by entry are not ...
Crampes, Claude, Langinier, Corinne
core
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Baseline White Matter Is Associated With Physical Fitness Change in Preclinical Alzheimer's Disease. [PDF]
Front Aging Neurosci, 2020 Venkatraman VK +14 more
europepmc +1 more source
Effect of Mineral and Organic Fertilization on desi and kabuli Chickpea (Cicer arietinum L.): Plant Growth and Production, Hydration Properties, Bioactive Compounds, and Antioxidant Activity. [PDF]
Plants (Basel), 2021 Pasqualone A +5 more
europepmc +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Whole-Process Risk Management of Soil Amendments for Remediation of Heavy Metals in Agricultural Soil-A Review. [PDF]
Int J Environ Res Public Health, 2023 Feng H, Cheng J.
europepmc +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Some Issues in the Calculation of Batting Averages: Ranking (and Re-Ranking) the Top 50 Batsmen in Test Cricket, 1877-2006 [PDF]
Batsmen in cricket are invariably ranked according to their batting average. Such a ranking suffers from two defects. First, it does not take into account the consistency of scores across innings: a batsman might have a high career average but with low ...
John Mangan, Vani K. Borooah
core
Friction- and Wear-Reducing Properties of Multifunctional Small Molecules.
ACS Applied Materials and Interfaces, 2018 L. Cosimbescu +3 more
semanticscholar +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source