ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini +12 more
wiley +1 more source
DA-MoE: descriptor-attention mixture-of-experts for multi-class gastrointestinal disease classification. [PDF]
Xu Y, Liu L, Tang M.
europepmc +1 more source
Vascular Disease, Non‐Steroidal Anti‐Inflammatory Drugs and Risk of Parkinson's Disease
ABSTRACT Objectives A history of vascular disease has been shown to be associated with an increased risk of Parkinson's disease, but this may be due to reverse causation. In addition, non‐steroidal anti‐inflammatory drugs are thought to reduce Parkinson's disease risk, but evidence is inconsistent and confounding by prior vascular disease is possible ...
Clare Wotton +4 more
wiley +1 more source
Automated lung cancer classification using intensity-driven RoI selection and transfer learning. [PDF]
Ahmed ST +5 more
europepmc +1 more source
Safety and Efficacy of GLP‐1 Receptor Agonists in Adults With Epilepsy, Obesity, and Type 2 Diabetes
ABSTRACT Objective Managing obesity in patients with epilepsy is complicated by the weight‐gaining properties of essential antiseizure medications (ASMs) such as valproate and pregabalin. We evaluated the safety and efficacy of initiating glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) in this population.
Hyoshin Son +3 more
wiley +1 more source
MPDD: A Curated Database Bridging Membrane Protein-Drug-Disease Landscapes. [PDF]
Lu Z +5 more
europepmc +1 more source
Prognostic Significance of the ESTRO/EORTC Classification of Oligometastatic Disease for Colorectal Cancer Patients With Uncommon Metastases Treated With Definitive Radiotherapy. [PDF]
Ke TW +11 more
europepmc +1 more source
Motor Imagery Acquisition and Classification Using a Low-Cost 8-Channel EEG System in a VR ADHD Serious Game Environment: A Case Study. [PDF]
Röhrling L +5 more
europepmc +1 more source
The Electrocardiogram-Based Phase Adjustment Task (PAT-ECG): An Open-Access Laboratory Test of Cardiac Interoceptive Accuracy. [PDF]
Hodgetts J +5 more
europepmc +1 more source

