Results 31 to 40 of about 14,974 (268)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Simulations of dense granular gases without gravity with impact-velocity-dependent restitution coefficient [PDF]

, 2007
We report two-dimensional simulations of strongly vibrated granular materials without gravity. The coefficient of restitution depends on the impact velocity between particles by taking into account both the viscoelastic and plastic deformations of ...
Andrews, Arsenović, Aumaître, Bizon, Bridges, Brilliantov, Eric Falcon, Falcon, Falcon, Falcon, Falcon, Falcon, Foerster, Goldman, Goldsmith, Haff, Hatzes, Herrmann, Hertzsch, Higa, Jenkins, Johnson, Kurtze, Kuwabara, Labous, Lan, Lifshitz, Luding, Luding, Luding, Luding, McNamara, McNamara, McNamara, Moon, Pöschel, Raman, Salo, Salueña, Schäfer, Sean McNamara, Spahn, Supulver, Tabor, Thornton, Turner   +45 more
core   +4 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Scaling behavior in the convection-driven Brazil-nut effect

, 2012
The Brazil-nut effect is the phenomenon in which a large intruder particle immersed in a vertically shaken bed of smaller particles rises to the top, even when it is much denser. The usual practice, while describing these experiments, has been to use the
Bandyopadhyay, Ranjini, Dhar, Abhishek, Hejmady, Prakhyat, Sabhapandit, Sanjib   +3 more
core   +2 more sources

Interplay between a hydrodynamic instability and a phase transition: the Faraday instability in dispersions of rodlike colloids [PDF]

, 2011
Strong effects of the Faraday instability on suspensions of rodlike colloidal particles are reported through measurements of the critical acceleration and of the surface wave amplitude.
Ballesta, Pierre, Lettinga, M. Paul, Manneville, Sebastien   +2 more
core   +2 more sources

Acoustic Measures Capture Speech Dysfunction in Spinocerebellar Ataxia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxias (SCA) are hereditary cerebellar degenerative disorders with a common feature of dysarthria, involving impaired phonatory and articulatory control of speech, thereby affecting social communication. In this study, we investigated whether acoustic measures could objectively measure speech dysfunction and identify
Zena Fadel, Charlotte Hennessey, Hannah Lee, Pia Parekh, Sheng‐Han Kuo, Ami Kumar   +5 more
wiley   +1 more source

Three-dimensional fluid motion in Faraday waves: creation of vorticity and generation of two-dimensional turbulence

, 2014
We study the generation of 2D turbulence in Faraday waves by investigating the creation of spatially periodic vortices in this system. Measurements which couple a diffusing light imaging technique and particle tracking algorithms allow the simultaneous ...
Francois, N., Punzmann, H., Ramsden, S., Shats, M., Xia, H.   +4 more
core   +4 more sources

Energy flows in vibrated granular media

, 1998
We study vibrated granular media, investigating each of the three components of the energy flow: particle-particle dissipation, energy input at the vibrating wall, and particle-wall dissipation.
A. D. Rosato, A. Goldshtein, A. Goldshtein, B. Bernu, C. K. K. Lun, E. Clément, F. Melo, I. Goldhirsch, J. Lee, J. T. Jenkins, M. Müller, P. Deltour, P. K. Haff, S. Luding, S. Luding, S. Luding, S. Luding, S. McNamara, S. McNamara, S. McNamara, S. Warr, Sean McNamara, Stefan Luding, V. Kumaran   +23 more
core   +1 more source

A 73‐Year‐Old Man With Several Years of Difficulty Climbing Stairs and Frequent Tripping

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 73‐year‐old man presented with progressive weakness and atrophy predominantly affecting the distal finger flexors and quadriceps muscles. Electrophysiological studies demonstrated mixed myogenic and neurogenic features. Muscle MRI showed inflammatory changes, and muscle biopsy revealed granulomatous myositis with histologic features ...
Mehmet Can Sari, Arens Taga, Sonya Ulrike Steele, Ahmet Hoke   +3 more
wiley   +1 more source