Results 81 to 90 of about 90,098 (266)

Effects of Trimethoprim on Three Previously Proposed Putative Biomarkers for OCT2/MATE‐Mediated Renal Drug‐Drug Interactions in Healthy Volunteers

Clinical Pharmacology &Therapeutics, EarlyView.
Regulatory agencies request the assessment of the potential of new drugs to cause transporter‐mediated drug‐drug interactions (DDI). This assessment can be improved by integrating endogenous biomarkers during drug development. Regarding the renal excretion of drugs such as metformin, the organic cation transporter (OCT) 2 and multidrug and toxin ...
Jana Picurová, Fabian Müller, Daniel Auge, Jörg König, Martin F. Fromm, Arne Gessner   +5 more
wiley   +1 more source

The Effect of Dicloxacillin Administration on Pharmacokinetics of Narrow Therapeutic Window Drugs: Phenytoin and Warfarin

Clinical Pharmacology &Therapeutics, EarlyView.
Dicloxacillin is a penicillinase‐resistant beta‐lactam antibiotic and potent activator of the Pregnane X receptor (PXR), known to induce CYP2C9, CYP2C19, and CYP3A4 activity. Clinical data suggest it reduces anticoagulation in warfarin‐treated patients and increases the risk of thromboembolic events.
Chanan Shaul, Waseem Mujahed, Ibrahim Idries, Maor Wanounou, Meir Bialer, Yoseph Caraco   +5 more
wiley   +1 more source

Integrated assessment of rifampicin‐mediated induction of transporters and drug‐metabolizing enzymes in a long‐term human liver tissue chip system

Clinical Pharmacology &Therapeutics, EarlyView.
Rifampicin is a prototypical clinical inducer used in drug–drug interaction (DDI) studies. However, the clinical relevance and predictability of rifampicin‐mediated hepatic transporter induction remain poorly defined. Conventional hepatocyte culture models fail to capture clinically relevant regulation of transporters and drug‐metabolizing enzymes ...
Mattie E. Hartauer, Raeanne M. Lanphier, Shivam Ohri, Jessica Snyder, Jacqueline B. Tiley, John K. Fallon, Henry Ho, Murat Cirit, Shiny Amala Priya Rajan, Kim L. R. Brouwer   +9 more
wiley   +1 more source

Analyzing the cyberbullying phenomenon on social media from the perspective of students

Frontiers in Psychology
IntroductionWith the significant increase in the number of social media users, the degree of cyberbullying has also increased in a directly proportional manner. Cyberbullying manifests itself in the commission of psychological abuses, teenagers being the
Maria Cristina Bularca, Sergiu Cristescu, Adrian Netedu, Claudiu Coman   +3 more
doaj   +1 more source

Defining Reconciliation Studies: Theoretical and Practical Dimensions

Conflict Resolution Quarterly, EarlyView.
ABSTRACT Reconciliation studies (RS) has become increasingly influential in understanding alternative views to ending conflict and dealing with the aftermath. As a discipline or field, however, it is not well defined. The actual usefulness of reconciliation (as a concept), or of RS (as a discipline), is debated, and due to its growing usage, it is ...
Colleen Alena O’Brien
wiley   +1 more source

Social Accounting for Work‐Related Injuries: Towards a Sustainable Management of Social Externalities

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT The present study seeks to advance the understanding of the determinants of occupational injuries, thereby enhancing both academic knowledge and decision‐making in the management and implementation of occupational health and safety measures.
Rosa María Cañaveras Perea, Ángel Tejada Ponce, María Pilar Sánchez González   +2 more
wiley   +1 more source

Leveraging Crisis Management for Minimising Brand Cancellation

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Brand misconduct can trigger negative consumer responses and escalate into brand crises. Effective crisis management is therefore essential to mitigate such responses and enhance organisational resilience. This study investigates the impact of various crisis communication strategies on consumer engagement and subsequent brand cancellation ...
Liyun Liu, Catherine Prentice, Susan Zeidan   +2 more
wiley   +1 more source

LPSK Integration At The Investigation Stage In Fulfilling The Rights Of Victims Of Sexual Violence

Jurnal Hukum Volkgeist
Fulfilling the rights of victims of criminal sexual violence is very important, starting from procedural rights, medical rights, psychological rights, and physical protection, but is often forgotten by law enforcement officials.
Muh Sutri Mansyah, Edy Nurcahyo, Kaswandi, Hasirudin Hasri, Hayun, Darojatun Andara, Muh. Ramlan, Sambar   +7 more
doaj   +1 more source

Exposing Gender Blindness in Business Scholarship on Modern Slavery

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT The objective of this review is to analyse the treatment of gender within business scholarship on modern slavery and to propose a framework that supports more gender‐sensitive corporate responses. Modern slavery risk is an escalating concern for business, with the United Nations calling for its eradication by 2030.
Kathyayini Kathy Rao, Roger Leonard Burritt, Katherine Leanne Christ   +2 more
wiley   +1 more source

Strategic Integration or Compliance Lag? Mapping Trends and Evolution of SBSC Through the Lens of the ESRS Framework

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT The sustainability balanced scorecard (SBSC) has become an influential framework for integrating sustainability into strategic management. Despite its growing adoption, research remains fragmented, and insufficiently aligned with the sustainability regulatory frameworks.
Biagio Maria Amico, Rafaela Gjergji, Valentina Lazzarotti   +2 more
wiley   +1 more source