Results 191 to 200 of about 66,264 (314)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Traditional Bullying Victimization and Cyberbullying Perpetration: the Role of Anger Rumination and Self-Control

Huaibin Jiang,1 Yinchuan Jin,2,3 Qun Yang2 1School of Education, Fujian Polytechnic Normal University, Fuzhou, People’s Republic of China; 2Department of Clinical Psychology, Fourth Military Medical University, Xi’an, People’s Republic of China ...
Jiang H, Yang Q, Jin Y
core   +1 more source

Examining Subtypes of Victimization in Saudi Arabia: A Comparative Analysis Across Gender Using PISA 2022. [PDF]

Children (Basel)
Sideridis G, Alghamdi MH.
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Longitudinal Relationships Between Bullying Victimization and Dual Social Behaviors: The Roles of Self-Compassion and Trauma-Related Shame

Xiaofang Xu,1 Yang Li,2 Shuyuan Liu,2 Wenchao Wang2 1School of Education Science, Luoyang Normal University, Luoyang, 471934, People’s Republic of China; 2Beijing Key Laboratory of Applied Experimental Psychology, National Demonstration Center for ...
Li Y, Wang W, Liu S, Xu X
core   +1 more source

Correlates of psychological distress and posttraumatic growth in survivors of sexual violence. [PDF]

Psychol Trauma
Bhuptani PH, Peterson R, Maloney M, Théorêt V, Adams-Clark A, Parker I, Orchowski LM.   +6 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Mental health and psychosocial sequelae of fraud victimization: a systematic review. [PDF]

Front Psychol
Bai J, Ho MH, Sung HT, Hung CS, Tsai JH.
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The chain mediating role of emotion dysregulation and non-suicidal self-injury in the relationship between cyber-victimization and suicidal ideation among college students. [PDF]

Aust J Psychol
Gao M, Zhou C, Diao J, Liu C, Zhang X, Wang H, Liu H, Lei Y.   +7 more
europepmc   +1 more source