Results 91 to 100 of about 66,264 (314)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Repeat and Near Repeat Burglary Victimization in Taiwan
, 2022 Extensive evidence shows that repeat victimization is common and widespread, but studies on the prevalence of repeat victimization in Asia are limited. This study examines the extent and patterns of repeat and near-repeat burglary victimization in Taiwan
Sidebottom, A +3 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
A study of children’s bullying victimization in Xi’an: prevalence, risk factors, and correlation with family violence [PDF]
, 2010 OBJECTIVE: Despite there is evidence supporting a substantial overlap between family violence and bullying victimization (Baldry, 2003; Shields & Cicchetti, 2001), few studies have been conducted to examine the co-occurrence or correlation between these ...
Chan, EKL, Yan, ECW, Zhu, Y
core
BMC PsychologyBackground Bullying and victimization have been studied in many contexts and classified as peer victimization in school settings and parental or sibling victimization within family settings.
Hacer Belen
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Study of family violence poly-victimization in China: design and preliminary findings [PDF]
, 2010 The population survey adopts a combined approach in using school and household-based approaches. The school-based approach is more appropriate to gather information from children aged 15 – 17 to estimate the prevalence of child victimization experienced ...
Chan, EKL, Fong, DYT
core
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source