Results 51 to 60 of about 2,667 (141)

Species-Dependent Structural Variations in Single-Domain Antibodies

open access: yesAntibodies
Background/Objectives: Single-domain antibodies (sdAbs) are derived from camelid heavy-chain antibodies (HCAb). Their small size, high stability, and ease of production, among other properties, makes them highly valuable in biomedical research and ...
Marta Baselga   +3 more
doaj   +1 more source

Taming interleukin‐12: Engineering of bispecific antibody‐based IL‐12 mimetics with biased agonism capacities

open access: yesProtein Science, Volume 34, Issue 3, March 2025.
Abstract In this work, we have generated bispecific interleukin (IL)‐12 surrogate agonists based on camelid‐derived single‐domain antibodies (sdAbs) targeting the IL‐12 receptor (IL‐12R) subunits IL‐12Rβ1 and IL‐12Rβ2. Following immunization and antibody display‐based paratope isolation, respective sdAbs were combinatorially reformatted into a ...
Britta Lipinski   +19 more
wiley   +1 more source

Sistemática, taxonomía y domesticación de alpacas y llamas: nueva evidencia cromosómica y molecular Systematics, taxonomy and domestication of alpaca and llama: new chromosomal and molecular evidence

open access: yesRevista Chilena de Historia Natural, 2007
Existen cuatro especies de camélidos sudamericanos, dos de ellos silvestres, guanaco (Lama guanicoe) y vicuña (Vicugna vicugna), y dos formas domésticas, alpaca (Lama pacos) y llama (Lama glama), cuyo origen ha sido objeto de debate.
JUAN C MARÍN   +10 more
doaj  

Cryptosporidium in Rabbits: A Global Systematic Review and Meta‐Analysis of Prevalence, Species/Genotypes Distribution and Zoonotic Significance

open access: yesVeterinary Medicine and Science, Volume 11, Issue 2, March 2025.
– Rabbits, often kept as pets, livestock and laboratory animals, can significantly influence the epidemiology and transmission of Cryptosporidium spp. to humans. – This systematic review and meta‐analysis assessed the global prevalence, species/genotype distribution and zoonotic impact of Cryptosporidium in rabbits.
Ali Ghorbani   +7 more
wiley   +1 more source

First cross-sectional, molecular epidemiological survey of Cryptosporidium, Giardia and Enterocytozoon in alpaca (Vicugna pacos) in Australia

open access: yesParasites & Vectors, 2018
Background Eukaryotic pathogens, including Cryptosporidium, Giardia and Enterocytozoon, have been implicated in neonatal diarrhoea, leading to marked morbidity and mortality in the alpaca (Vicugna pacos) and llama (Lama glama) around the world. Australia
Anson V. Koehler   +5 more
doaj   +1 more source

Exploring the importance of predicted camel NRAP exon 4 for environmental adaptation using a mouse model

open access: yesAnimal Genetics, Volume 56, Issue 1, February 2025.
Abstract Camels possess exceptional adaptability, allowing them to withstand extreme temperatures in desert environments. They conserve water by reducing their metabolic rate and regulating body temperature. The heart of the camel plays a crucial role in this adaptation, with specific genes expressed in cardiac tissue that are essential for mammalian ...
Sung‐Yeon Lee   +5 more
wiley   +1 more source

Phosphoantigen recognition by Vγ9Vδ2 T cells

open access: yesEuropean Journal of Immunology, Volume 54, Issue 11, November 2024.
Binding of microbial or host metabolites (phosphoantigens) to the intracellular Β30.2 domain of butyrophilin (BTN)3A1 (green) initiates binding to B30.2 domains of the BTN2A1 homodimer and results in the formation of a Vγ9Vδ2 TCR ligand which may also include additional components.
Thomas Herrmann   +1 more
wiley   +1 more source

Left displacement of the third gastric compartment in an alpaca: the first case report in China

open access: yesBMC Veterinary Research, 2022
Background Left displacement of the third gastric compartment (LDC3) in alpacas is an extremely rare condition and has not been reported thus far. Therefore, we describe the clinical diagnosis and treatment of LDC3 in an alpaca.
Yuxi Song   +6 more
doaj   +1 more source

Variación genética en los genes HOXC13 y KRT31 de alpaca (Vicugna pacos)

open access: yesManglar, 2020
El objetivo del presente estudio fue identificar y caracterizar genéticamente polimorfismos de nucleótido único (SNPs) del gen HOXC13 y KRT31 en una población de alpacas Huacaya de Huancavelica, Perú.
William Salas   +3 more
doaj   +1 more source

Hypoosmotic swelling test in alpaca (Vicugna pacos) spermatozoa recovered the vas deferens [PDF]

open access: yesSPERMOVA, 2015
The study objective was to evaluate the endosmotic reaction in 5 hypoosmotic solutions 100, 125, 150, 175 and 200 mOsm/l (HOS test) incubated 5 and 15 minutes using alpaca sperm recovered the vas deferens.
Quispe HA   +4 more
doaj   +1 more source

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