Results 71 to 80 of about 60,489 (250)

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

open access: yesAdvanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao   +5 more
wiley   +1 more source

Longitudinal Morphomolecular Monitoring of Head and Neck Carcinogenesis

open access: yesAdvanced Science, EarlyView.
A miniaturized endoscopic probe that integrates Raman spectroscopy and optical coherence tomography, enabling simultaneous molecular and structural imaging of living tissue, was developed. Applied longitudinally in a mouse model of head and neck cancer, the system tracks disease progression from precancerous lesions to invasive cancer.
Jianrong Qiu   +7 more
wiley   +1 more source

Pulmonary Lipoma in an Atypical Location of the Pulmonary Fissure, Extirpated by Uniportal VATS – Case Report and Review of Literature

open access: yesEuropean Medical Journal Respiratory, 2020
Lipomas are common benign tumours characterised by soft moveable masses throughout various locations in the body. However, atypical localisation of the pulmonary fissure is uncommon.
Daniel Bulyashki   +5 more
doaj   +1 more source

Video-assisted Thoracic Surgery Lobectomy

open access: yesThe Korean Journal of Thoracic and Cardiovascular Surgery, 2011
Video-assisted thoracoscopic surgery (VATS) has been established as the surgical approach of choice for lobectomy in patients with early-stage non-small cell lung cancer (NSCLC). Patients with clinical stage I NSCLC with no lymph node metastasis are considered candidates for VATS lobectomy.
openaire   +2 more sources

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

open access: yesAdvanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang   +12 more
wiley   +1 more source

The Mind From Within: Visceral Roots of Human Cognition

open access: yesAdvanced Science, EarlyView.
The physiological activity of visceral organs, such as the heart, the lungs, and the gut, is surprisingly linked to many sophisticated mental operations, such as remembering the past, being aware of ourselves, making choices, and forging social bonds.
Alessandro Monti   +1 more
wiley   +1 more source

(Video Assisted) thoracoscopic surgery: Getting started

open access: yesJournal of Minimal Access Surgery, 2007
Thoracoscopic surgery without or with video assistance (VATS) is simpler and easier to learn as it seems to be. Potential benefits of the procedure in rural surgical environment are outlined while basic requirements and limitations are listed ...
Molnar Tamas
doaj  

COMPLICACIONES DE LA CIRUGÍA CARDÍACA VIDEO-ASISTIDA / Complications of video-assisted heart surgery [PDF]

open access: yesCorSalud, 2012
ResumenLa cirugía cardiovascular video-asistida incluye procedimientos extremadamente complejos, como la revascularización miocárdica y las sustituciones valvulares, no exentos de complicaciones fácilmente prevenibles y tratables.
Fausto L. Rodríguez Salgueiro   +4 more
doaj  

Uniportal video-assisted thoracic surgery

open access: yesAnnals of Cardiothoracic Surgery, 2016
Even though the development of thoracoscopic procedures has a history of over a hundred years, it is only in the last two decades that interest in minimally invasive thoracic surgery has been renewed by two key technological improvements. These are the development of endoscopic cameras offering a panoramic view and the availability of new endoscopic ...
openaire   +3 more sources

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

open access: yesAdvanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha   +4 more
wiley   +1 more source

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