Results 31 to 40 of about 711,286 (269)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Analytical Model and Feedback Predictor Optimization for Combined Early-HARQ and HARQ

Mathematics, 2021
In order to fulfill the stringent Ultra-Reliable Low Latency Communication (URLLC) requirements towards Fifth Generation (5G) mobile networks, early-Hybrid Automatic Repeat reQuest (e-HARQ) schemes have been introduced, aimed at providing faster feedback
Tatiana Rykova, Barış Göktepe, Thomas Schierl, Konstantin Samouylov, Cornelius Hellge   +4 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Sparse Weighted Constrained Energy Minimization for Accurate Remote Sensing Image Target Detection

Remote Sensing, 2017
Target detection is an important task for remote sensing images, while it is still difficult to obtain satisfied performance when some images possess complex and confusion spectrum information, for example, the high similarity between target and ...
Ying Wang, Miao Fan, Jie Li, Zhaobin Cui
doaj   +1 more source

Seismic Data Augmentation Based on Conditional Generative Adversarial Networks

Sensors, 2020
Realistic synthetic data can be useful for data augmentation when training deep learning models to improve seismological detection and classification performance.
Yuanming Li, Bonhwa Ku, Shou Zhang, Jae-Kwang Ahn, Hanseok Ko   +4 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Real-Time Tracking Framework with Adaptive Features and Constrained Labels

Sensors, 2016
This paper proposes a novel tracking framework with adaptive features and constrained labels (AFCL) to handle illumination variation, occlusion and appearance changes caused by the variation of positions.
Daqun Li, Tingfa Xu, Shuoyang Chen, Jizhou Zhang, Shenwang Jiang   +4 more
doaj   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Consistently Sampled Correlation Filters with Space Anisotropic Regularization for Visual Tracking

Sensors, 2017
Most existing correlation filter-based tracking algorithms, which use fixed patches and cyclic shifts as training and detection measures, assume that the training samples are reliable and ignore the inconsistencies between training samples and detection ...
Guokai Shi, Tingfa Xu, Jie Guo, Jiqiang Luo, Yuankun Li   +4 more
doaj   +1 more source