Results 201 to 210 of about 32,626 (263)

Sex‐specific acceleration of Alzheimer's pathogenesis by chronic sleep‐deprivation

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Sleep impairments likely contribute to Alzheimer's pathology, though specific contributions to disease progression are incompletely understood. We propose that autophagic impairment is associated with chronic sleep disruption and examine how sleep loss and stress influence disease development, including having impacts on ...
Darcy Wear, Christopher Daniel Morrone, Dominic Simpson, Fang Liu, Syed Abid Hussaini, Wai Haung Yu   +5 more
wiley   +1 more source

Shoulder and Knee Arthroscopy Access Point: Prospective Comparison of Sonographic and Palpatory Detection - Which Method is Better for Novices? [PDF]

Ultrasound Int Open
Weimer AM, Weimer JM, Berthold S, Stein S, Müller L, Buggenhagen H, Balser G, Stankov K, Sgroi M, Schmidmaier G, Kloeckner R, Schamberger C.   +11 more
europepmc   +1 more source

APP‐mediated intracellular signaling rescues sleep impairment and blood–brain barrier leakage in Alzheimer's disease mouse model

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Amyloid beta peptide (Aβ) accumulation in the brain is an Alzheimer´s disease (AD) hallmark. Sleep disturbances hamper Aβ production and clearance, thereby exacerbating the Aβ burden. The mechanisms involved remain unclear. We reported that amyloid precursor protein (APP), the Aβ source, possesses intracellular signaling that ...
Clémentine Puech, Anjana Sadanand, Neil Coleman, Marilyn Ikhane, Mohammad Badran, Rong Wang, David Gozal, Angèle T. Parent   +7 more
wiley   +1 more source

A Robotic Hand Surpassing Human Capabilities in Dexterity and Functionality

Gao X, Yao K, Junge K, Hughes J, Billard AG.   +4 more
europepmc   +1 more source

The Reactome Knowledgebase 2026. [PDF]

Nucleic Acids Res
Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, Griss J, Hogue GFJ, Li NT, Matthews L, May B, Milacic M, Mohammadi H, Petryszak R, Rothfels K, Shamovsky V, Stephan R, Tiwari K, Weiser J, Wright A, Gillespie M, Wu G, Stein L, Hermjakob H, D'Eustachio P.   +24 more
europepmc   +1 more source

Deep cervical lymphatic–venous anastomosis attenuates cognitive dysfunction and biomarker abnormalities in severe Alzheimer's disease: A prospective single‐arm study

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION This study evaluated the efficacy of deep cervical lymphatic–venous anastomosis (dcLVA) for severe Alzheimer's disease (AD). METHODS A total of 139 severe AD patients undergoing dcLVA were enrolled, and changes in cognitive function and biomarkers were evaluated by comparing preoperative measures with postoperative outcomes over a
Xiaohong Fu, Jing Zhang, Qiuxia Xiao, Tingting Li, Qijun Li, Shaofu Zhang, Wen Zeng, Min Gong, Pan Cai, Zhaojian Deng, Xuan Zhang, Yuanjun Xin, Liping Su, Xiaohe Tian, Kaifeng Wu, Liulin Xiong   +15 more
wiley   +1 more source

Methodology for the knowledge-based selection of occupational exoskeletons. [PDF]

Prod Eng
Drees T, Ralfs L, Reimeir B, Lemmerz K, Weidner R, Kuhlenkötter B.   +5 more
europepmc   +1 more source

AI and Big Data in Oncology: A Physician‐Centered Perspective on Emerging Clinical and Research Applications

Cancer Innovation, Volume 5, Issue 1, February 2026.
Artificial intelligence and big data platforms are transforming oncology clinical practice. This review proposes a physician‐centered framework to integrate AI tools with real‐world data, supporting more precise diagnosis, individualized treatment, and improved patient outcomes.
Binliang Liu, Qingyao Shang, Jun Li, Shuna Yao, Meishuo Ouyang, Yu Wang, Sheng Luo, Quchang Ouyang   +7 more
wiley   +1 more source

The practical year: a qualitative study on stressors, resources and proposed improvements among medical students. [PDF]

BMC Med Educ
Guthardt L, Franck S, Muth T, Loerbroks A.   +3 more
europepmc   +1 more source

Vildagliptin and Omarigliptin Differentially Bind to DPP‐4 Homodimers and Modulate Osteoclast‐Mediated Bone Resorption

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
Vildagliptin and omarigliptin, dipeptidyl peptidase‐4 (DPP‐4) inhibitors, have differential effects on bone cells. Although vildagliptin improved the bone microstructure of high‐fat diet‐fed rats, it was unable to downregulate osteoclastogenesis or the expression of key osteoclast transcripts.
Ratchaneevan Aeimlapa, Jiraporn Panmanee, Jarinthorn Teerapornpuntakit, Kannikar Wongdee, Jirawan Thongbunchoo, Nattapon Panupinthu, Saovaros Svasti, Nattayaporn Apaijai, Piangkwan Sa‐nguanmoo, Siriporn Chattipakorn, Nipon Chattipakorn, Narattaphol Charoenphandhu   +11 more
wiley   +1 more source