Results 171 to 180 of about 1,038,095 (251)

Microbial‐Metabolite Signatures Are Associated With Glucocorticoid Responsiveness in Chronic Rhinosinusitis With Nasal Polyps

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) exhibit heterogeneous responses to oral glucocorticoids (GCs), but the biological basis of this variability remains unclear. Objective To identify gut microbiome‒plasma metabolomic signatures associated with GC responsiveness in CRSwNP patients and to compare their ...
Ying‐Ying Zhang   +7 more
wiley   +1 more source

Structure and Function of a Multi‐Megadalton Virus‐Like Proteolytic Dodecahedron

open access: yesAngewandte Chemie, EarlyView.
Zuzalysin, a virulence metallopeptidase of the periodontal pathogen Porphyromonas gingivalis, is secreted as a latent, flexible ≈95‐kDa monomer. Calcium triggers cysteine‐switch activation and hierarchical assembly into pentamers, bipentamers, tripentamers, and a ≈5.6‐MDa, ≈355‐Å dodecahedron. Structures at 1.8–3.6 Å reveal a virus‐sized catalytic cage
Mariusz Madej   +20 more
wiley   +2 more sources

Psychometric Evaluation of the Importance of Olfaction Questionnaire Using Item Response Theory

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
Key Points The IOQ measures the value patients place on olfaction, a construct distinct from disease burden. The IOQ is most precise across the central trait range typical of routine ENT patients. Association items carry most measurement information, enabling a brief affective screen.
Alexander Lein   +3 more
wiley   +1 more source

Beyond MVPA minutes: physical activity phenotypes are associated with metabolic profiles in children with obesity. [PDF]

open access: yesEur J Pediatr
Gatti A   +7 more
europepmc   +1 more source

Prediction of First and Recurrent Falls in Parkinson's Disease

open access: yesAnnals of Neurology, EarlyView.
Objective To develop and externally validate prediction models for next‐year falls in Parkinson's disease (PD), and to evaluate the incremental value of imaging and fluid biomarkers. Methods We developed models in Parkinson's Progression Markers Initiative (PPMI) to predict next‐year falls with external validation in University of Pennsylvania (UPenn ...
Joaquin A. Vizcarra   +13 more
wiley   +1 more source

Salivary cortisol response to post-exercise infrared sauna declines over time. [PDF]

open access: yesTemperature (Austin)
Ahokas EK   +3 more
europepmc   +1 more source

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