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The Specific Features of the System History of the International Relations and World Politics

open access: yesПроблемы постсоветского пространства, 2023
The article considers the specific features of the system approach to the history of international relations and world politics. International relations are viewed as a single complex organism, which is greater than the sum of its parts.
I. V. Kolosova
doaj   +1 more source

Problems of the foreign policy of the Holy See during the Pontificate of Gregory XVI (1831–1846)

open access: yesВестник Тамбовского университета. Серия: Гуманитарные науки, 2023
The analysis of the main directions of the foreign policy of the Holy See under Pope Gregory XVI (1831–1846) is carried out. A review of the scientific literature on the life and work of the pontiff is made.
A. A. Tereshchuk
doaj   +1 more source

Molecular Mingling: Multimodal Predictions of Ligand Promiscuity in Pentameric Ligand-Gated Ion Channels

open access: yesFrontiers in Molecular Biosciences, 2022
Background: Human pentameric ligand-gated ion channels (pLGICs) comprise nicotinic acetylcholine receptors (nAChRs), 5-hydroxytryptamine type 3 receptors (5-HT3Rs), zinc-activated channels (ZAC), γ-aminobutyric acid type A receptors (GABAARs) and glycine
Filip Koniuszewski   +8 more
doaj   +1 more source

Navigating the complex landscape of benzodiazepine- and Z-drug diversity: insights from comprehensive FDA adverse event reporting system analysis and beyond

open access: yesFrontiers in Psychiatry, 2023
IntroductionMedications which target benzodiazepine (BZD) binding sites of GABAA receptors (GABAARs) have been in widespread use since the nineteen-sixties. They carry labels as anxiolytics, hypnotics or antiepileptics.
Filip Koniuszewski   +6 more
doaj   +1 more source

DNA Methylation Associates With Clinical Courses of Atypical Meningiomas: A Matched Case–Control Study

open access: yesFrontiers in Oncology, 2022
BackgroundAccounting for 15–20% of all meningiomas, WHO grade II meningiomas represent an intermediate group regarding risk of tumor recurrence. However, even within this subgroup varying clinical courses are observed with potential occurrence of ...
Matthias Millesi   +21 more
doaj   +1 more source

Cys-loop receptors on cannabinoids: All high?

open access: yesFrontiers in Physiology, 2022
Endocannabinoids (eCBS) are endogenously derived lipid signaling molecules that serve as tissue hormones and interact with multiple targets, mostly within the endocannabinoid system (ECS).
Philip Schmiedhofer   +3 more
doaj   +1 more source

Heme Biosynthesis Factors and 5-ALA Induced Fluorescence: Analysis of mRNA and Protein Expression in Fluorescing and Non-fluorescing Gliomas

open access: yesFrontiers in Medicine, 2022
ObjectiveThe intraoperative visualization of adult-type diffuse gliomas with 5-aminolevulinic acid (5-ALA) induced fluorescence is widely used in the neurosurgical field.
Mario Mischkulnig   +23 more
doaj   +1 more source

The impact of heme biosynthesis regulation on glioma aggressiveness: Correlations with diagnostic molecular markers

open access: yesFrontiers in Molecular Neuroscience, 2022
BackgroundThe prognosis of diffusely infiltrating glioma patients is dismal but varies greatly between individuals. While characterization of gliomas primarily relied on histopathological features, molecular markers increasingly gained importance and ...
Mario Mischkulnig   +21 more
doaj   +1 more source

Targeted Metabolomics and High-Throughput RNA Sequencing-Based Transcriptomics Reveal Massive Changes in the Streptomyces venezuelae NRRL B-65442 Metabolism Caused by Ethanol Shock

open access: yesMicrobiology Spectrum, 2022
The species Streptomyces venezuelae is represented by several distinct strains with variable abilities to biosynthesize structurally diverse secondary metabolites.
Olga N. Sekurova   +5 more
doaj   +1 more source

THE CONCEPT OF “THE CONCERT OF EUROPE” IN XX CENTURY BRITISH AND AMERICAN HISTORIOGRAPHY

open access: yesVestnik MGIMO-Universiteta, 2016
The article provides a critical analysis of the interpretations of the Concert of Europe by British and American historians of the XXth century. The interest in the study of this phenomenon is rooted in its relation to the problems of the maintenance of ...
E. V. Romanova
doaj   +1 more source

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